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Forskolin regulates retinal endothelial cell permeability through TLR4 actions in vitro
Mol Cell Biochem. 2021 Aug 28. doi: 10.1007/s11010-021-04252-9. Online ahead of print.ABSTRACTTo investigate whether forskolin, a protein kinase A agonist, regulates toll-like receptor 4 actions on retinal endothelial cell permeability in vitro. We also evaluated whether PKA could regulate TLR4 signaling independent of exchange protein activated by cAMP in REC in culture. REC were grown in normal (5 mM) or high (25 mM) glucose. Cells were treated with forskolin to increase PKA levels, siRNA against TLR4, siRNA against myeloid differentiation primary response 88, siRNA against translocating chain associated membrane protein...
Source: Molecular and Cellular Biochemistry - September 9, 2021 Category: Biochemistry Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research

Effects of miR-202-5p silencing PIK3CA gene expression on proliferation, invasion, and epithelial-mesenchymal transition of cervical cancer SiHa cells through inhibiting PI3K/Akt/mTOR signaling pathway activation
In conclusion, the overexpression of miR-202-5p can suppress PIK3CA gene expression and the activation of PI3K/Akt/mTOR signaling pathway to suppress the proliferation, invasion, and EMT of cervical cancer.PMID:34244973 | DOI:10.1007/s11010-021-04211-4
Source: Molecular and Cellular Biochemistry - July 10, 2021 Category: Biochemistry Authors: Yan Zheng Lei Xie Shuwen Xu Weidong Yan Hongzhen Zhang Yali Meng Jingqiao Liu Xujing Wei Source Type: research

Hepatocyte steatosis inhibits hepatitis B virus secretion via induction of endoplasmic reticulum stress
Mol Cell Biochem. 2021 May 13. doi: 10.1007/s11010-021-04143-z. Online ahead of print.ABSTRACTThe effects of hepatocyte steatosis on hepatitis B virus (HBV) DNA replication and HBV-related antigen secretion are incompletely understood. The aims of this study are to explore the effects and mechanism of hepatocyte steatosis on HBV replication and secretion. Stearic acid (SA) and oleic acid (OA) were used to induce HepG2.2.15 cell steatosis in this study. The expressions of glucose-regulated protein 78 (GRP78), phosphorylation of protein kinase R-like endoplasmic reticulum (ER) kinase (p-PERK), and eukaryotic translation init...
Source: Molecular and Cellular Biochemistry - May 13, 2021 Category: Biochemistry Authors: Qichuang Liu Maoyuan Mu Huan Chen Guoyuan Zhang Yanqing Yang Jun Chu Ying Li Fangwan Yang Shide Lin Source Type: research

Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP
Mol Cell Biochem. 2021 Apr 2. doi: 10.1007/s11010-021-04131-3. Online ahead of print.ABSTRACTGalectin-3(Gal-3) is an effective regulator in the pathological process of pulmonary arterial hypertension (PAH). However, the detailed mechanisms underlying Gal-3 contribution to PAH are not yet entirely clear. The aim of the present study was to explore these issues. Proliferation of rat pulmonary arterial smooth muscle cells (PASMCs) was determined using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Small interfering RNA (siRNA) was applied to silence the expression of yes-associated protein (YAP) a...
Source: Molecular and Cellular Biochemistry - April 2, 2021 Category: Biochemistry Authors: Qianqian Zhang Wenge Li Yanting Zhu Qingting Wang Cui Zhai Wenhua Shi Wei Feng Jian Wang Xin Yan Limin Chai Yuqian Chen Cong Li Pengtao Liu Manxiang Li Source Type: research

Omega-3 fatty acid protects cardiomyocytes against hypoxia-induced injury through targeting MiR-210-3p/CASP8AP2 axis
Mol Cell Biochem. 2021 Mar 31. doi: 10.1007/s11010-021-04141-1. Online ahead of print.ABSTRACTMicroRNAs (miRs) regulate diverse biological functions in both normal and pathological cellular conditions by post-transcriptional regulation of various genes expression. Nevertheless, the role of miRs in regulating the protective functions of omega-3 fatty acid in relation to hypoxia in cardiomyocytes remains unknown. The aim of this study was to investigate the effects of omega-3 fatty acid supplementation on cardiomyocyte apoptosis and further delineate the mechanisms underlying microRNA-210 (miRNA-210)-induced cardiomyocyte ap...
Source: Molecular and Cellular Biochemistry - April 1, 2021 Category: Biochemistry Authors: Xueju Yu Fengyao Liu Yuting Liu Bingqing Bai Han Yin Haochen Wang Yingqing Feng Huan Ma Qingshan Geng Source Type: research

SAA1 regulates pro-labour mediators in term labour by activating YAP pathway
In conclusion, these experiments demonstrated that SAA1 accelerates the inflammatory response associated with parturition by activating YAP pathway, which may be a novel understanding of the molecular mechanism of labour onset.PMID:33719002 | DOI:10.1007/s11010-021-04125-1
Source: Molecular and Cellular Biochemistry - March 15, 2021 Category: Biochemistry Authors: Yanmin Jiang Li Pin Weiqun Shi Qian Huang Lele Wang Huishu Liu Source Type: research

KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity.
CONCLUSIONS: The results of this study demonstrated that hyperglycemia aggravated Bup neurotoxicity by upregulating KLF9 expression, which repressed the antioxidant PRDX6 and led to mitochondrial dysfunction, ROS burst, and cell death. Understanding this mechanism may, thus, offer valuable insights for the prevention and treatment of neurotoxicity induced by LAs, especially in diabetic patients. PMID: 33547545 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - February 5, 2021 Category: Biochemistry Authors: Li H, Weng Y, Lai L, Lei H, Xu S, Zhang Y, Li L Tags: Mol Cell Biochem Source Type: research

Activation of STING inhibits cervical cancer tumor growth through enhancing the anti-tumor immune response.
In this study, we found that the cGAS (Cyclic GMP-AMP synthase)/STING signal decreased in cervical cancer cells. Knockdown of STING by siRNA enhanced the cell viability and migration of cervical cancer cells, while activation of STING by ADU-S100 inhibited the cell viability of cervical cancer cells, with no effect on the migration and apoptosis. In addition, ADU-S100 promoted the secretion of IFNβ and IL-6, and the activation of TBK1 (TANK-binding kinase 1)/NF-κB (nuclear factor kappa-B) pathway. Meanwhile, knockdown of STING inhibited the production of IFNβ and IL-6 that were triggered by dsDNA and suppressed the TBK1...
Source: Molecular and Cellular Biochemistry - November 3, 2020 Category: Biochemistry Authors: Shi F, Su J, Wang J, Liu Z, Wang T Tags: Mol Cell Biochem Source Type: research

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