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Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies
Allergy Asthma Immunol Res. 2021 May;13(3):375-389. doi: 10.4168/aair.2021.13.3.375.ABSTRACTSevere asthma (SA) is a heterogeneous disease characterized by uncontrolled symptoms, frequent exacerbations, and lung function decline. The discovery of phenotypes and endotypes of SA significantly improves our understanding of its pathophysiology and allows the advent of biologics blocking multiple molecular targets. The advances have mainly been made in type 2-high asthma associated with elevated type 2 inflammatory biomarkers such as immunoglobulin E (IgE), interleukins (IL)-4, IL-5, and IL-13. Previous clinical trials have demo...
Source: Allergy, Asthma and Immunology Research - March 18, 2021 Category: Allergy & Immunology Authors: Youngsoo Lee Quang Luu Quoc Hae Sim Park Source Type: research
