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The High Throughput Biomedicine unit at the Institute for Molecular Medicine Finland: High throughput screening meets precision medicine.
Abstract The High Throughput Biomedicine (HTB) unit at the Institute for Molecular Medicine Finland FIMM was established in 2010 to serve as a national and international academic screening unit providing access to state of the art instrumentation for chemical and RNAi-based high throughput screening. The initial focus of the unit was multiwell plate based chemical screening and high content microarray-based siRNA screening. However, over the first four years of operation, the unit has moved to a more flexible service platform where both chemical and siRNA screening is done at different scales primarily in multiwel...
Source: Combinatorial Chemistry and High Throughput Screening - March 23, 2014 Category: Chemistry Authors: Pietiäinen V, Saarela J, Schantz-Fant CV, Turunen L, Ostling P, Wennerberg K Tags: Comb Chem High Throughput Screen Source Type: research

The Role of HTS in Drug Discovery at the University of Michigan.
Abstract High throughput screening (HTS) is an integral part of a highly collaborative approach to drug discovery at the University of Michigan. The HTS lab is one of four core centers that provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key features of this system are: protein cloning and purification, protein crystallography, small molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and anti-viral. The centers work in a coordinate...
Source: Combinatorial Chemistry and High Throughput Screening - January 9, 2014 Category: Chemistry Authors: Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH Tags: Comb Chem High Throughput Screen Source Type: research