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Drug: Magnesium
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Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Apr 20;41(4):475-482. doi: 10.12122/j.issn.1673-4254.2021.04.01.ABSTRACTOBJECTIVE: The investigate the inhibitory effects of the traditional Chinese medicine (TCM) monomer salvianolic acid B (Sal-B) and its magnesium salt Salvia Miltiorrhiza Polyphenolate Injection (ZDDY) against SARS-CoV-2 infection in vitro and explore the molecular mechanism.OBJECTIVE: The anti-SARS-CoV-2 activity of Sal-B and ZDDY was assessed using the authentic and pseudotyped SARS-CoV-2 infection assay. The antiviral targets of Sal-B were identified by molecular docking and molecular dynamics simulation. Circular ...
Source: Journal of Southern Medical University - May 8, 2021 Category: Universities & Medical Training Authors: C Yang C Cheng J Wang K Chen J Zhan X Pan X Xu W Xu S Liu Source Type: research
