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Drug: Magnesium

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Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Apr 20;41(4):475-482. doi: 10.12122/j.issn.1673-4254.2021.04.01.ABSTRACTOBJECTIVE: The investigate the inhibitory effects of the traditional Chinese medicine (TCM) monomer salvianolic acid B (Sal-B) and its magnesium salt Salvia Miltiorrhiza Polyphenolate Injection (ZDDY) against SARS-CoV-2 infection in vitro and explore the molecular mechanism.OBJECTIVE: The anti-SARS-CoV-2 activity of Sal-B and ZDDY was assessed using the authentic and pseudotyped SARS-CoV-2 infection assay. The antiviral targets of Sal-B were identified by molecular docking and molecular dynamics simulation. Circular ...
Source: Journal of Southern Medical University - May 8, 2021 Category: Universities & Medical Training Authors: C Yang C Cheng J Wang K Chen J Zhan X Pan X Xu W Xu S Liu Source Type: research

Outcomes of older COVID-19 patients in Acute Care at Home, Southern HSC Trust, Northern Ireland, from March - June 2020
CONCLUSION: The data indicates that hypoxaemia, hyperferritinaemia and hypermagnesaemia are associated with early mortality in the older population infected with COVID-19. National Early Warning Score and frailty score are predictive of mortality in this cohort, with higher scores correlating to worse outcomes. Those living in LTCF are at an increased risk of mortality. However, ACAH mortality rates are comparable to those admitted to hospital, validating the concept of ACAH. The highlighted trends can be used to improve outcomes in future admissions.PMID:34815595 | PMC:PMC8581692
Source: The Ulster Medical Journal - November 24, 2021 Category: General Medicine Authors: Fiachra Keenan Emma Warnock Margaret Rice Kate Allen Jonathan Warnock Peter Beck Bushra Khan Patricia McCaffrey Source Type: research