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SELENON (SEPN1) protects skeletal muscle from saturated fatty acid-induced ER stress and insulin resistance
Publication date: Available online 23 March 2019Source: Redox BiologyAuthor(s): Ersilia Varone, Diego Pozzer, Simona Di Modica, Alexander Chernorudskiy, Leonardo Nogara, Martina Baraldo, Mario Cinquanta, Stefano Fumagalli, Rocio Nur Villar-Quiles, Maria-Grazia De Simoni, Bert Blaauw, Ana Ferreiro, Ester ZitoAbstractSelenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of function leads to congenital myopathies associated with insulin resistance (SEPN1-related myopathies). The exact cause of the insulin resistance in patients with SELENON loss of function is not known. Skeletal muscle is the main con...
Source: Redox Biology - March 24, 2019 Category: Biology Source Type: research

Pharmacometabolomic signature links simvastatin therapy and insulin resistance
ConclusionWithin this short 6  weeks study, some patients became hyperglycemic and/or insulin resistant. Diabetic markers were associated with decarboxylated small aminated metabolites as well as a branched chain amino acid directly linked to glucose metabolism and fatty acid biosynthesis. Pharmacometabolomics provides powerful tools for precision medicine by predicting development of drug adverse effects in sub populations of patients. Metabolic profiling prior to start of drug therapy may empower physicians with critical information when prescribing medication and determining prognosis.
Source: Metabolomics - December 22, 2016 Category: Biology Source Type: research