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Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
Publication date: 5 August 2014 Source:Molecular and Cellular Endocrinology, Volume 393, Issues 1–2 Author(s): Nicola A. Talbot , Caroline P. Wheeler-Jones , Mark E. Cleasby Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle are unknown. Here, macrophages were treated with palmitic acid, palmitoleic acid or both and the effects of the conditioned medium (CM) on C2C12 myotubes investigated. CM from palmitic acid-treated...
Source: Molecular and Cellular Endocrinology - November 23, 2014 Category: Endocrinology Source Type: research

Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator-activated receptor gamma-mediated inhibition of breast cancer cell growth
Publication date: 5 January 2015 Source:Molecular and Cellular Endocrinology, Volume 399 Author(s): Cindy K. Pon , Sue M. Firth , Robert C. Baxter We have previously reported that insulin-like growth factor binding protein-3 (IGFBP-3), a protein with dichotomous effects on both cell proliferation and cell survival, interacts with peroxisome proliferator-activated receptor gamma (PPARγ) and inhibits adipogenic PPARγ signaling. We now show that IGFBP-3 and PPARγ interact in breast cancer cells, through amino- and carboxyl-terminal residues of IGFBP-3. IGFBP-3 and the PPARγ ligands, rosiglitazone or 15-deoxy-Δ12,14-pro...
Source: Molecular and Cellular Endocrinology - November 13, 2014 Category: Endocrinology Source Type: research

Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator activated receptor gamma-mediated inhibition of breast cancer cell growth
Publication date: Available online 31 October 2014 Source:Molecular and Cellular Endocrinology Author(s): Cindy K. Pon , Sue M. Firth , Robert C. Baxter We have previously reported that insulin-like growth factor binding protein-3 (IGFBP-3), a protein with dichotomous effects on both cell proliferation and cell survival, interacts with peroxisome proliferator-activated receptor gamma (PPARγ) and inhibits adipogenic PPARγ signaling. We now show that IGFBP-3 and PPARγ interact in breast cancer cells, through amino- and carboxyl-terminal residues of IGFBP-3. IGFBP-3 and the PPARγ ligands, rosiglitazone or 15-deoxy-Δ12,...
Source: Molecular and Cellular Endocrinology - November 3, 2014 Category: Endocrinology Source Type: research

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