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Inhibition of apolipoprotein A‐I gene expression by tumor necrosis factor alpha in HepG2 cells: Requirement for c‐jun
Abstract Tumor necrosis factor alpha (TNF α) signals in part through the mitogen activated protein (MAP) kinase c‐jun‐N‐terminal kinase (JNK). Activation of JNK has been shown to promote insulin resistance and dyslipidemia, including reductions in plasma high‐density lipoprotein (HDL) and apolipoprotein A‐I (apo A‐I). To examine how TNF α‐mediated JNK activation inhibits hepatic apo A‐I production, the effects of c‐jun activation on apo A‐I gene expression were examined in HepG2 cells. Apo A‐I gene expression and promoter activity were measured by Northern and Western blotting and transient transfec...
Source: Journal of Cellular Biochemistry - August 22, 2013 Category: Biochemistry Authors: Shant Parseghian, Luisa M. Onstead‐Haas, Norman C.W. Wong, Arshag D. Mooradian, Michael J. Haas Tags: Article Source Type: research

Inhibition of Apolipoprotein A‐I Expression by TNF‐Alpha in HepG2 Cells: Requirement for c‐jun
ABSTRACT Tumor necrosis factor alpha (TNF α) signals in part through the mitogen activated protein (MAP) kinase c‐jun‐N‐terminal kinase (JNK). Activation of JNK has been shown to promote insulin resistance and dyslipidemia, including reductions in plasma high‐density lipoprotein (HDL) and apolipoprotein A‐I (apo A‐I). To examine how TNF α‐mediated JNK activation inhibits hepatic apo A‐I production, the effects of c‐jun activation on apo A‐I gene expression were examined in HepG2 cells. Apo A‐I gene expression and promoter activity were measured by Northern and Western blotting and transient transfec...
Source: Journal of Cellular Biochemistry - December 13, 2013 Category: Biochemistry Authors: Shant Parseghian, Luisa M. Onstead‐Haas, Norman C.W. Wong, Arshag D. Mooradian, Michael J. Haas Tags: Article Source Type: research

Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 20, 2016 Category: Biochemistry Authors: Gaurav Pandey, Kripa Shankar, Ekta Makhija, Anil Gaikwad, Carolyn Ecelbarger, Anil Mandhani, Aneesh Srivastava, Swasti Tiwari Tags: Article Source Type: research