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The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics.
In conclusion, development of a novel 3D cell culture model of prostate cancer bone metastasis has been initiated resulting, for the first time, in the successful delivery of gene therapeutics in a 3D in vitro model. Further enhancement of this model will help elucidate the pathogenesis of prostate cancer and also accelerate the design of effective therapies which can penetrate into the bone microenvironment for prostate cancer therapy. PMID: 26196533 [PubMed - as supplied by publisher]
Source: Biomaterials - July 14, 2015 Category: Materials Science Authors: Fitzgerald KA, Guo J, Tierney EG, Curtin CM, Malhotra M, Darcy R, O'Brien FJ, O'Driscoll CM Tags: Biomaterials Source Type: research

Star-Shaped Amphiphilic Hyperbranched Polyglycerol Conjugated with Dendritic Poly(l-lysine) for the Codelivery of Docetaxel and MMP-9 siRNA in Cancer Therapy
ACS Applied Materials & InterfacesDOI: 10.1021/acsami.6b01611
Source: ACS Applied Materials and Interfaces - May 11, 2016 Category: Materials Science Authors: Xiaoyan Zhou, Qianqian Zheng, Changyong Wang, Jiake Xu, Jian-Ping Wu, Thomas Brett Kirk, Dong Ma and Wei Xue Source Type: research