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Targeting Phospholipase D4 Attenuates Kidney Fibrosis
Phospholipase D4 (PLD4), a single-pass transmembrane glycoprotein, is among the most highly upregulated genes in murine kidneys subjected to chronic progressive fibrosis, but the function of PLD4 in this process is unknown. Here, we found PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine and human kidneys after fibrosis. Genetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial cells, protected mice from the development of fibrosis. Mechanistically, global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the upregulation of ...
Source: Journal of the American Society of Nephrology : JASN - November 30, 2017 Category: Urology & Nephrology Authors: Trivedi, P., Kumar, R. K., Iyer, A., Boswell, S., Gerarduzzi, C., Dadhania, V. P., Herbert, Z., Joshi, N., Luyendyk, J. P., Humphreys, B. D., Vaidya, V. S. Tags: Basic Research Source Type: research