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Abstract 971: Phosphatase PTP4A3 is critical for cell growth of triple-negative breast cancer
Conclusion: These studies identified a set of highly expressed phosphatases that represent promising targets for the treatment of TNBCs. We also demonstrated that one of these phosphatases, PTP4A3, is critical for the growth of TNBCs in vitro and in vivo, and PTP4A3 expression is prognostic in women with TNBC. These results provide the rationale for further study of growth promoting phosphatases and suggest that such phosphatases may be targeted for the treatment of this aggressive form of breast cancer. Research supported by: Susan G. Komen for the Cure (PB, GM), Komen SAB, and the Norman Brinker Award for Research Excell...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Hollander, P. d., Tismelzon, A., Shepherd, J., Rawls, K. R., Hill, J. L., Mazumdar, A., Hilsenbeck, S. G., Mills, G. B., Brown, P. H. Tags: Molecular and Cellular Biology Source Type: research

Blockade of Ubiquitin Receptor PSMD4/Rpn10 Triggers Cytotoxicity and Overcomes Bortezomib-Resistance in Multiple Myeloma
ConclusionOur preclinical data validates targeting 19S proteasome ubiquitin receptor Rpn10 upstream of the proteasome in the ubiquitin proteasomal cascade, and provides the framework for clinical evaluation of Rpn10 inhibitors to overcome PI resistance and improve patient outcome in MM.DisclosuresAnderson: C4 Therapeutics: Equity Ownership, Other: Scientific founder; Celgene: Consultancy; Bristol Myers Squibb: Consultancy; Gilead: Membership on an entity's Board of Directors or advisory committees; Millennium Takeda: Consultancy; OncoPep: Equity Ownership, Other: Scientific founder.
Source: Blood - November 21, 2018 Category: Hematology Authors: Song, Y., Ray, A., Chauhan, D., Anderson, K. Tags: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Poster II Source Type: research