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Question 1: Co-trimoxazole dosing dilemma: what is the right dose?
Scenario While covering the paediatric haematology–oncology ward, you are asked to prescribe co-trimoxazole for prophylaxis against Pneumocystis jirovecii pneumonia (PJP). You refer to your usual drug resources discovering a variety of different dosing options and wonder which regimen you should prescribe. Structured clinical question In immunocompromised children and adolescents without HIV infection (patient), which co-trimoxazole dosing regimen (intervention) is most effective in preventing PJP and best tolerated (outcome)? Search strategy and outcome We searched Medline (1946 to current) and Embase (1974 to curre...
Source: Archives of Disease in Childhood - October 19, 2015 Category: Pediatrics Authors: Boast, A., Osowicki, J., Cole, T., Curtis, N., Gwee, A. Tags: ADC Archimedes, Oncology, Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Pneumonia (infectious disease), TB and other respiratory infections, Adolescent health, Child health, Infant health, Pneumonia (respirat Source Type: research

Availability of Pyrimethamine: Statement from Adult & Adolescent OI Guideline Panel
Pyrimethamine is recommended for treatment and/or prophylaxis of Toxoplasma encephalitis, Pneumocystis pneumonia, and Isospora infection. As of June 2015, pyrimethamine is no longer available in retail pharmacies in the United States. It is only available through a special pharmacy program (http://www.daraprimdirect.com/how-to-prescribe). If there is a delay in procuring pyrimethamine for a patient in whom it is needed for one of the above indications, please refer to the specific pathogen section for alternative drug regimens for treatment or prophylaxis. For patients with suspected or documented toxoplasmosis who do not ...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - September 11, 2015 Category: Infectious Diseases Source Type: news

Cross-reactivity between darunavir and trimethoprim-sulfamethoxazole in HIV-infected patients
Conclusion: Although DRV allergy is uncommon, making cross-reactivity with TMP-SMX a rare clinical problem, it appears to exist more often in the background of a TMP-SMX allergy.
Source: AIDS - March 28, 2015 Category: Infectious Diseases Tags: Clinical Science Source Type: research