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Single-cell immunopathology of systemic contact allergy associated with corticosteroids
Allergic contact dermatitis (CD) is a delayed hypersensitivity reaction with keratinocyte-directed cytotoxicity mediated by CD8+ T-cells [1]. Despite association with topical exposure, in rare instances presentation may follow systemic exposure to corticosteroids following prior sensitisation through skin [2]. Among corticosteroids, methylprednisolone and other Coopman group ‘A’ structures classified by structural substitution on C16 of the D ring are thought more immunogenic based on prevalence of reporting [3], but rarity of systemically-induced CD (SCD) has limited investigation of cellular immunopathogenesis.
Source: Journal of Dermatological Science - December 17, 2021 Category: Dermatology Authors: Rebecca J Hertzman, Pooja Deshpande, Katie D White, Rama Gangula, Abha Chopra, Ramesh Ram, John A Zic, Jeffrey P Zwerner, Andrew Gibson, Elizabeth J Phillips Tags: Letter to the Editor Source Type: research

Are the Spanish baseline series markers sufficient to detect contact allergy to corticosteroids in Spain? A GEIDAC prospective study
ConclusionsMore than half of the patients who were allergic to the additionally tested corticosteroids were not detected with the corticosteroid allergy markers. An update of the corticosteroid allergy screening markers is encouraged, with consideration of group 3 corticosteroids.
Source: Contact Dermatitis - September 27, 2017 Category: Dermatology Authors: Pedro Mercader ‐García, María A. Pastor‐Nieto, Ignacio García‐Doval, Ana Giménez‐Arnau, Ricardo González‐Pérez, Virginia Fernández‐Redondo, Ester Serra‐Baldrich, Susana Cordoba‐Guijarro, María E. Gatica‐Ortega, Juan F. Silvestre� Tags: Original Article Source Type: research

TNF receptor ‐associated periodic syndrome (TRAPS) mimicking chronic spontaneous urticaria
This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - May 13, 2017 Category: Dermatology Authors: S Aurich, J C Simon, R Treudler Tags: Letter to Editor Source Type: research