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Drug: Methotrexate
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Chikungunya Infection: a Global Public Health Menace
AbstractChikungunya virus (CHIKV) has been involved in epidemics in African and Asian subcontinents and, of late, has transcended to affect the Americas.Aedes aegypti andAedes albopictus are the major vectors for CHIKV infection, which results in dissemination of virus to various vital organs. Entry of virus into these tissues causes infiltration of innate immune cells, monocytes, macrophages, neutrophils, natural killer cells, and adaptive immune cells. Macrophages bearing the replicating virus, in turn, secrete pro-inflammatory cytokines IL-1 β, TNF-α, and IL-17. Together, this pro-inflammatory milieu induces osteoclas...
Source: Current Allergy and Asthma Reports - February 23, 2017 Category: Allergy & Immunology Source Type: research
