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Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate.
Abstract People with diabetes mellitus have shorter telomeres compared with non-diabetic subjects. The aim of this study was to investigate an in-vitro model of telomere shortening under diabetes metabolic conditions. The mechanisms of the accelerated telomere length attrition and the potential telomere protective action of fenofibrate with related cellular mechanisms were also examined. Human dermal fibroblasts were passaged and cultured in normal (5.5 mM) or high (25 mM) D-glucose, across 7 days with hydrogen peroxide (H2O2), glucosamine (GA), or glycated albumin (AGEs-BSA). Relative telomere length (RTL) was...
Source: Journal of Cell Communication and Signaling - June 14, 2019 Category: Molecular Biology Authors: Sutanto SSI, McLennan SV, Keech AC, Twigg SM Tags: J Cell Commun Signal Source Type: research