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Severe asthma in children: shall we carry out systematic bronchoalveolar lavage?
This study aims at deciphering if a systematic BAL during a flexible bronchoscopy procedure could improve phenotyping severe asthma. Secondary objectives were to evaluate BAL impact on asthma control and on flexible bronchoscopy morbidity.Patients and methods: The study was held in two departments of Armand Trousseau University Hospital in Paris, France. Children who underwent a flexible bronchoscopy for severe asthma exploration were retrospectively included between April 2017 and September 2019.Results: A total of 203 children were included, 107 had a BAL and 96 did not. BAL fluid cell count showed no abnormality in most...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Ben Tkhayat, R., Just, J., Nathan, N. Tags: Paediatric asthma and allergy Source Type: research

The impact of anti-IgE treatment on the airway microbiome in asthma
Conclusions: These findings suggest monoclonal asthma treatments such as omalizumab may affect lung microbial diversity.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Sullivan, A., Ward, C., Casey, D., Flynn, D., Hunt, E. B., Eustace, J. A., O' Byrne, P. M., Plant, B. J., Macsharry, J. A., Murphy, D. M. Tags: Allergy and immunology Source Type: research