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High Potassium Promotes Mutual Interaction between (Pro)Renin Receptor and the Local Renin-Angiotensin-Aldosterone System in Rat IMCD Cells.
Abstract (Pro)renin receptor (PRR) is predominantly expressed in the collecting duct (CD) with unclear functional implication. It is not known whether CD PRR is regulated by high potassium (HK). Here, we aimed to investigate the effect of HK on PRR expression and its role in regulation of aldosterone synthesis and release in the CD. In primary rat inner medullary CD cells, HK augmented PRR expression and soluble PPR (sPRR) release in a time- and dose- dependent manner, which was attenuated by PRR siRNA, eplerenone, and losartan. HK upregulated aldosterone release in parallel with an increase of CYP11B2 (cytochrome...
Source: Am J Physiol Cell Ph... - August 16, 2016 Category: Cytology Authors: Xu C, Fang H, Zhou L, Lu A, Yang T Tags: Am J Physiol Cell Physiol Source Type: research