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Total 90 results found since Jan 2013.
Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation
This study aimed to determine the transcript level of PCa-related genes, HPN and IMPDH2, in archived tissues. Their functional roles were further determined using an in vitro model of PCa. Total RNA extraction was done from formalin-fixed paraffin-embedded PCa tissues, and benign prostatic hyperplasia (BPH) tissues acted as the control. Quantitative real-time polymerase chain reaction (qPCR) was performed to measure HPN and IMPDH2 expression. The functional assay was performed in a prostate cancer cell line (DU145) on these two genes by silencing their RNA. We discovered a significantly higher expression of IMPDH2 in PCa s...
Source: Malaysian Journal of Pathology - April 29, 2022 Category: Pathology Authors: N A Wahab H D Dardar R Yunus Z M Zainudin N M Mokhtar Source Type: research
Tomato Solanum lycopersicum expressing the overlapping regions of three begomovirus genes exhibit resistance to Ageratum yellow vein Malaysia virus
We report the development of tomato lines showing resistance to Ageratum yellow vein Malaysia virus (AYVMV) a monopartite begomovirus and a causative agent for leaf curling, cupping, crinkling and stunting disease in the tomato cultivar MT1. The plants were transformed with a hp-RNAi construct “pHells-C1C2C3” consisting of overlapping regions of the C1, C2 and C3 genes of AYVMV. Progenies of two transgenic tomato lines (L132 and L18) exhibited resistance to AYVMV infection after inoculation with viruliferous whiteflies. The relative viral DNA accumulation levels at different times post inoculation were either not detec...
Source: Physiological and Molecular Plant Pathology - July 6, 2019 Category: Molecular Biology Source Type: research
