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Severe onset of inflammatory myositis in a child: think to paraneoplastic myositis
ConclusionsAmong cancer-associated autoantibodies (CAAs) in adult patients, anti-TIF1- γ carries the highest risk of CAM, which recognizes with a high likelihood a paraneoplastic pathogenesis. In children, anti-TIF1-γ antibody has been associated with severe cutaneous disease, lipodystrophy, and chronic disease course, but not with CAM, which is overall rare in younger patients. Sev ere onset of a JIIM, especially if anti-TIF1-γ antibody positive, should prompt suspect of a CAM and lead to a screening for malignancy.
Source: Italian Journal of Pediatrics - July 1, 2021 Category: Pediatrics Source Type: research
