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Rhinitis phenotypes and multimorbidities in the general population: the CONSTANCES cohort
Conclusions In this large population-based cohort, 40% reported current rhinitis, with a lower prevalence of moderate-to-severe rhinitis than in clinical practice. For the first time in a general adult population, we showed that AR and NAR alone or in combination with asthma or in combination with asthma and conjunctivitis are different phenotypes. These results provide new insights on how best to manage rhinitis and its multimorbidities.
Source: European Respiratory Journal - February 9, 2023 Category: Respiratory Medicine Authors: Savoure, M., Bousquet, J., Leynaert, B., Renuy, A., Siroux, V., Goldberg, M., Zins, M., Jacquemin, B., Nadif, R. Tags: Asthma and allergy Original Research Articles Source Type: research

Maternal diet during pregnancy with allergic and respiratory profiles in children
Conclusion: In a large nationwide cohort, maternal diet quality during pregnancy was weakly related to allergic and respiratory multimorbidity profiles up to 5.5 years. These preliminary results should be further explored by studying more specific food groups or scores.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Delvert, R., Charles, M., Dumas, O., Leynaert, B., Nadif, R., Plancoulaine, S., Raherison, C., Sedki, M., Varraso, R., De Lauzon-Guillain, B., Bedard, A. Tags: 07.06 - Paediatric respiratory epidemiology Source Type: research

Influence of asthma on ARIA classification of allergic rhinitis in the French population-based cohort Constances
Conclusion: This is a paradigm changing study as, for the first time we show how taking asthma status into account modify ARIA classification. Moreover, it was done in a large population-based study in adults. This study confirms that rhinitis alone and rhinitis and asthma represent two entirely different phenotypes. This new classification should be used for new guidelines.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Savoure, M., Bousquet, J., Leynaert, B., Goldberg, M., Zins, M., Jacquemin, B., Nadif, R. Tags: 06.01 - Epidemiology Source Type: research

Foetal exposure to heavy metals and risk of asthma and allergic diseases in early childhood: a population-based birth-cohort study
Conclusions: Our results suggest that prenatal exposure to heavy metals may affect the development of asthma and allergic diseases in childhood.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Pesce, G., Baiz, N., Huel, G., Annesi Maesano, I., On behalf of the EDEN consortium Tags: Occupational and environmental health Source Type: research

Mepolizumab in a population with severe eosinophilic asthma and corticosteroid dependence: results from a French early access programme
This study aimed to characterise patients who received mepolizumab in the nATU. Methods This retrospective, observational study analysed data from the hospital medical records of patients up to 24 months after treatment initiation. Study objectives were to describe patient baseline characteristics, the evolution of disease severity and treatment modifications during follow-up; safety was also investigated. Findings Overall, 146 patients who received ≥1 dose of mepolizumab were included. At inclusion, patients had a mean age of 58.2 years with a mean severe asthma duration of 13.4 years, and 37.0% had re...
Source: European Respiratory Journal - June 24, 2020 Category: Respiratory Medicine Authors: Taille, C., Chanez, P., Devouassoux, G., Didier, A., Pison, C., Garcia, G., Charriot, J., Bouee, S., Gruber, A., Pribil, C., Bourdin, A., Humbert, M. Tags: Original Articles: Asthma Source Type: research

Burden of pollen allergy in 3 European countries: AIS LIFE project
Conclusions: there is a relevant clinical impact of pollen allergy in 3 European countries which should prompt measures to reduce such environmental exposure. Supported by EU LIFE program, project no. LIFE13 ENV/IT/001107.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Baldacci, S., Maio, S., Simoni, M., Angino, A., Silvi, P., La Grutta, S., Viegi, G., Ruggiero, F., Bedini, G., Natali, F., Cecchi, L., Prentovic, M., Berger, U., Moustafa, A., Annesi-Maesano, I., Monnier, S., Thibaudon, M., Orlandini, S. Tags: Epidemiology Source Type: research

Breast-milk microbes and risk of asthma by 6 years of age
Conclusions: Our data supports breast-milk as a considerable source of early-life microbial exposure and provides the first indication that microbes in breast-milk may affect the risk of asthma and thus have prolonged impact on child health.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hämynen, I., Täubel, M., Karvonen, A., Orivuori, L., Vaarala, O., Hyvärinen, A., Riedler, J., Roduit, C., Lauener, R., Dalphin, J.-C., Von Mutius, E., Remes, S., Pekkanen, J., Kirjavainen, P. V. Tags: Paediatric asthma and allergy Source Type: research

Specific IgE sensitization and asthma in French farmers
Conclusion: Our screening identified IgE reactivity in 41% of French farmers. The most common IgE reactivities were wasp venom, house dust mites, and grass pollens. Both allergic and non-allergic asthma were observed in this sample. Whether and how allergic sensitization is associated with the development of clinical manifestations of allergies in farmers needs further investigation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Clerc, S., Caillaud, D., Maesano, C., Vitte, J., Annesi-Maesano, I. Tags: Occupational and Environmental Health Source Type: research