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Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance.
Abstract Pro-inflammatory pathways in adipose tissue macrophages (ATMs) can impair glucose tolerance in obesity, but ATMs may also be beneficial as repositories for excess lipid that adipocytes are unable to store. To test this hypothesis, we selectively targeted visceral ATMs in obese mice with siRNA against lipoprotein lipase (LPL), leaving macrophages within other organs unaffected. Selective silencing of ATM LPL decreased foam cell formation in visceral adipose tissue of obese mice, consistent with a reduced supply of fatty acids from VLDL hydrolysis. Unexpectedly, silencing LPL also decreased the expression o...
Source: Am J Physiol Endocri... - July 1, 2014 Category: Endocrinology Authors: Aouadi M, Vangala P, Yawe JC, Tencerova M, Cohen JL, Nicoloro SM, Shen Y, Czech MP Tags: Am J Physiol Endocrinol Metab Source Type: research