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Reticulon 3 Regulates VLDL Secretion by Controlling VTV Biogenesis.
Abstract Secretion of very low-density lipoprotein (VLDL) by the liver is an important physiological process; however, the rate of VLDL secretion is determined by its transport from the ER to the Golgi. This transport event is facilitated by a specialized ER-derived vesicle, the VLDL transport vesicle (VTV). We have reported earlier a detailed VTV proteome which revealed that reticulon 3 (RTN3) is uniquely present in the VTV. Our immunoblotting and electron microscopic data demonstrate that RTN3 is enriched in the VTV; however, other ER-derived vesicles do not contain RTN3. Co-immunoprecipitation data coupled with...
Source: Canadian Journal of Physiology and Pharmacology - May 14, 2018 Category: Drugs & Pharmacology Authors: Siddiqi S, Zhelyabovska O, Siddiqi SA Tags: Can J Physiol Pharmacol Source Type: research

Sodium pump alpha-2 subunit (ATP1A2) alleviates cardiomyocyte anoxia/reoxygenation injury via inhibition of endoplasmic reticulum stress-related apoptosis.
Abstract Previous studies have found decreased functional capacity of the sodium pump (Na+-K+-ATPase) alpha and beta subunits and recovery of Na+-K+-ATPase activity significantly decreased myocyte apoptosis in myocardial ischemia-reperfusion (I/R) injury. However, the potential role of the Na+-K+-ATPase α-2 subunit (ATP1A2) in cardiomyocyte anoxia/reoxygenation (A/R) injury has not been elucidated. Rat myocardial cells were subjected to siRNA transfection followed by A/R injury. Apoptosis and expression of endoplasmic reticulum (ER) stress proteins CHOP, GRP78, and Caspase-12 were detected in four groups of cells...
Source: Canadian Journal of Physiology and Pharmacology - February 2, 2018 Category: Drugs & Pharmacology Authors: Hu Y, Wang Z, Ge N, Huang T, Zhang M, Wang H Tags: Can J Physiol Pharmacol Source Type: research

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