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Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space (P1.103)
Conclusions:Our approach may be used to bridge the gap between results from the neurosurgical literature and modern neuroimaging and makes it possible to study network effects of DBS based on prior literature findings.Study Supported by:AH received funding from Stiftung Charité; Berlin Institute of Health and Prof. Klaus Thiemann Foundation. He received travel stipends from Movement Disorders Society and Ipsen Pharma. AAK was supported by the German Research Agency (DFG - Deutsche Forschungsgemeinschaft). Grant Number: KFO 247 and received honoraria from St Jude Medical and Medtronic; travel grants from Ipsen Pharma...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Horn, A., Kuhn, A., Merkl, A., Shih, L., Alterman, R., Fox, M. Tags: Movement Disorders Poster Discussion Session Source Type: research

UCLA researchers identify molecular ‘switch’ that causes Huntington’s disease–like symptoms in mice
This study makes clear that a major neuroprotective function of N17 is to prevent the mutant protein from entering the nucleus and eliciting more severe toxicities,” Yang said, adding that the result is consistent with findings from several studies of other, related disorders in which mutant proteins with expanded glutamine in the nucleus are key for jump-starting a disease. The researchers also found that the mice in the study experienced inflammation in the brain somewhat similar to that found in people with Huntington’s. “Neuroinflammation is emerging as a potentially shared mechanism in multiple neurodegenerative...
Source: UCLA Newsroom: Health Sciences - February 13, 2015 Category: Universities & Medical Training Source Type: news