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Modulation of the autophagy ‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke
We report for the first time that the protective effect of β-hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D-BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D-BHB notably reduced the activation of the PERK and IRE1α branches of the unfolded protein response (UPR), attenuating protein synthesis inhibition and preventing endoplasmic reticulum stress. Together our results support the therapeutic use of D-BHB treatment post-ischemia, by preventing the loss of proteos...
Source: Journal of Neurochemistry - June 17, 2023 Category: Neuroscience Authors: Teresa Montiel,
Juan Carlos G ómora‐García,
Cristian Gerónimo‐Olvera,
Yessica Heras‐Romero,
Berenice N. Bernal‐Vicente,
Xochitl Pérez‐Martínez,
Luis B. Tovar‐y‐Romo,
Lourdes Massieu Tags: ORIGINAL ARTICLE Source Type: research
