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Employment status, social function decline and caregiver burden among stroke survivors. A South Indian study
Conclusions: Loss of occupation among stroke survivors is high. The decline in social function among stroke survivors and caregivers was significant. Even though functional disability contributed to employment loss and social function decline among stroke survivors, it did not have a significant impact on caregiver burden.
Source: Journal of the Neurological Sciences - July 29, 2013 Category: Neurology Authors: Sapna Erat Sreedharan, J.P. Unnikrishnan, M.G. Amal, B.S. Shibi, Sankara Sarma, P.N. Sylaja Tags: Original Articles Source Type: research

Repeated intravenous thrombolysis after recurrent stroke. A case series and review of the literature
Conclusions: IV re-thrombolysis may be safe and effective when recurrent stroke occurs after a period of complete neurologic regression lasting at least 24h or minor disability (mRS score ≤2) lasting at least 3months since the previous stroke.Highlights:
Source: Journal of the Neurological Sciences - July 25, 2014 Category: Neurology Authors: Manuel Cappellari, Giuseppe Moretto, Paolo Bovi Tags: Original Articles Source Type: research

Validity, reliability and minimum detectable change of the maximum step length test in people with stroke
Abstract: Stroke is a significant cause of deficits in balance, mobility and disability. Although tests of stepping speed are associated with balance performance after stroke, relationships between clinical tests of stepping distance and balance performance have not been investigated in people with stroke. A validated test of stepping distance and balance in older adults (the maximum step length [MSL] test), and two clinical measures associated with balance in people with stroke (the five-times-sit-to-stand test [FTSST] and gait speed) were evaluated in nineteen independent community-dwelling people with chronic stroke. Th...
Source: Journal of the Neurological Sciences - December 26, 2012 Category: Neurology Authors: Vicky Pardo, Dale Knuth, Bridget McDermott, Joseph Powell, Allon Goldberg Tags: Original Articles Source Type: research

Management of post-stroke depression in the Middle East and North Africa: Too little is known
Stroke is among the most common disabilities among adults and most stroke victims live in developing countries. However, little is known about services delivered in these countries for post-stroke depression, a common comorbidity that influences functional outcomes of stroke. In this paper, a physician from Syria reviews the literature on post-stroke depression among patients living in countries of the Middle East and North Africa region in order to examine whether current practices can be improved.
Source: Journal of the Neurological Sciences - May 12, 2017 Category: Neurology Authors: M. Ihsan Kaadan, Mary Jo Larson Tags: Review Article Source Type: research

Mission thrombectomy 2020 (MT2020+) surveys of Caribbean stroke services: A call for action in our region
Stroke is the leading cause of death and adult-onset disability in the Caribbean region. Despite the tremendous advances in acute stroke care in the past 25  years, treatment in the Caribbean lags stroke standards of care. Mission Thrombectomy 2020+ (MT2020+) is a metrics based global campaign focused on increasing access to organized stroke care and mechanical thrombectomy.We conducted two consecutive online surveys across the MT2020+ Caribbean Regio n assessing access to thrombolytics, mechanical thrombectomy and stroke centers.
Source: Journal of the Neurological Sciences - March 31, 2023 Category: Neurology Authors: Gillian Gordon Perue, Ryna Then, Francene Gayle, Siddharth Galav, Yuvateja Thotamalla, Madihah Hepburn, Daidre Rowe, Luis Suazo, Cosme Villam án, Herbert Manosalva, Santiago Ortega-Gutierrez, Dileep Yavagal, Violiza Inoa, On behalf of MT2020+ Caribbean I Source Type: research

Gastrointestinal complications after ischemic stroke
Ischemic stroke is an important cause of morbidity and mortality, and currently the leading cause of adult disability in developed countries. Stroke is associated with various non-neurological medical complications, including infections and thrombosis. Gastrointestinal complications after stroke are also common, with over half of all stroke patients presenting with dysphagia, constipation, fecal incontinence or gastrointestinal bleeding. These complications are associated with increased hospital length of stay, the development of further complications and even increased mortality.
Source: Journal of the Neurological Sciences - September 4, 2014 Category: Neurology Authors: Carlos R. Camara-Lemarroy, Beatriz E. Ibarra-Yruegas, Fernando Gongora-Rivera Tags: Review article Source Type: research

Stroke minimization through additive anti-atherosclerotic agents in routine treatment (SMAART): A pilot trial concept for improving stroke outcomes in sub-Saharan Africa
There has been an unprecedented rise in the prevalence of stroke in sub-Saharan Africa (SSA), which when compared to stroke profiles in high-income countries (HIC) is characterized by a younger age of onset, higher case fatality rates, and more severe disability among survivors. Stroke survivors in SSA (vs. HIC) are especially at high risk for recurrent vascular events or death due to undiagnosed or under-controlled vascular risk factors, logistical challenges, low health literacy, and lack of care affordability.
Source: Journal of the Neurological Sciences - April 11, 2017 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Tags: Review Article Source Type: research

Acute stroke rehabilitation for gait training with cyborg type robot Hybrid Assistive Limb: A pilot study
Robot-assisted gait training following acute stroke could allow patients with severe disability to receive a high dosage and intensity of gait training compared with conventional physical therapy (CP). However, given the limited data on gauging the efficacy of Hybrid Assistive Limb (HAL) on gait training in patients with acute stroke, we aimed to evaluate several outcome measures following gait training with HAL. Patients with first-ever stroke, who required a walking aid and were able to start gait training within 1  week of stroke onset were included in the current study.
Source: Journal of the Neurological Sciences - July 9, 2019 Category: Neurology Authors: Chiaki Yokota, Yukio Yamamoto, Masatoshi Kamada, Michikazu Nakai, Kunihiro Nishimura, Daisuke Ando, Takeo Sato, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda, Yasuyuki Fujimoto, Hirotaka Odani, Kazuo Minematsu, Takashi Nakajima Source Type: research

Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes
Ischemic stroke is a major cause of premature death and chronic disability worldwide, and individual variation in functional outcome is strongly influenced by genetic factors. Neuroendocrine signaling by the hypothalamic −hypophyseal−thyroid axis is a critical regulator of post-stroke pathogenesis, suggesting that allelic variants in thyroid hormone (TH) signaling can influence stroke outcome.Aim: To examine associations between acute ischemic stroke (AIS) outcome and allelic variants of the TH metabolizing enzy mes deiodinase type 1–3 (DIO1–3) and membrane transporting organic anion polypeptide C1 (OATP1C1).
Source: Journal of the Neurological Sciences - September 10, 2019 Category: Neurology Authors: Saulius Taroza, Daiva Rastenyt ė, Aurelija Podlipskytė, Vaiva Patamsytė, Narseta Mickuvienė Source Type: research

Could immediate blood pressure reduction after acute ischemic stroke prevent early recurrent strokes?
We read, with great interest, the JAMA article by Dr. He and his colleagues suggesting that modest blood pressure (BP) reduction by 10–25% within the first 24h after randomization and maintained at less than 140/90mmHg for an average hospitalization period of 13days did not reduce the likelihood of death and major disability at 14days or hospital discharge, compared with the absence of antihypertensive medication. The study results provide important evidence about the utility of BP management for enhancing two key outcomes in the immediate post-stroke period. While the conclusions seem appropriate, the authors do not dis...
Source: Journal of the Neurological Sciences - April 8, 2014 Category: Neurology Authors: Wuwei (Wayne) Feng, Bruce Ovbiagele Tags: Letters to the Editor Source Type: research

Trends in Stroke Admission and Mortality Rates from 1983 to 2013 in Central Ghana
Accumulating data based on model-derived estimates suggest rising rates of stroke in sub-Saharan Africa over the next several decades. Stroke is a leading cause of death, disability, and dementia worldwide. Directly enumerated hospital-based data on the longitudinal trajectory of stroke admissions and deaths in sub-Saharan Africa could help hospital administrators, public health officials, and government policy-makers with planning and utilization of scarce resources.
Source: Journal of the Neurological Sciences - August 3, 2015 Category: Neurology Authors: Fred S. Sarfo, John Akassi, Dominic Awuah, Sheila Adamu, Clara Nkyi, Mayowa Owolabi, Bruce Ovbiagele Source Type: research

Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke
Ischemic stroke remains a leading cause of disability, particularly among the elderly, but this association has not been consistently noted among patients with minor stroke. We sought to determine the association of chronological age and leukoaraiosis, which is considered a marker of biological age, with the degree of neurological deficit recovery and 90-day disability after minor ischemic stroke.
Source: Journal of the Neurological Sciences - October 6, 2015 Category: Neurology Authors: Sanjeeva R. Onteddu, Richard P. Goddeau, Artin Minaeian, Nils Henninger Source Type: research

Heart failure and the risk of ischemic stroke recurrence: A systematic review and meta-analysis
Heart failure (HF) is known to be a major risk factor for first-ever ischemic stroke (IS), and is associated with greater stroke severity and higher rates of early mortality and residual disability. There are limited data regarding the association of HF with stroke recurrence. We sought to evaluate the relationship between HF and recurrent IS using a comprehensive meta-analytical approach. We performed a systematic literature review according to PRISMA guidelines to identify all prospective study protocols (randomized clinical trials or observational cohorts) that reported rates of IS recurrence in patients with concomitant HF.
Source: Journal of the Neurological Sciences - January 26, 2016 Category: Neurology Authors: Aristeidis H. Katsanos, John Parissis, Alexandra Frogoudaki, Agathi-Rosa Vrettou, Ignatios Ikonomidis, Ioannis Paraskevaidis, Nikolaos Triantafyllou, Odysseas Kargiotis, Konstantinos Voumvourakis, Andrei V. Alexandrov, Georgios Tsivgoulis Source Type: research

Addressing post-stroke care in rural areas with Peru as a case study. Placing emphasis on evidence-based pragmatism
Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local healthcare workers and family caregivers in these regions lack the necessary knowledge to assist them. Intriguingly, a recent rapid growth in cell-phone use and digital technology in rural areas has not yet been appropriately exploited for health care training and delivery purposes.
Source: Journal of the Neurological Sciences - February 13, 2017 Category: Neurology Authors: J. Jaime Miranda, Miguel G. Moscoso, Lijing L. Yan, Francisco Diez-Canseco, Germ án Málaga, Hector H. Garcia, Bruce Ovbiagele Tags: Review Article Source Type: research

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