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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Disability
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Total 286 results found since Jan 2013.
Acute Ischemic Stroke with Vessel Occlusion —Prevalence and Thrombectomy Eligibility at a Comprehensive Stroke Center
Introduction: Endovascular thrombectomy (ET) for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) can prevent severe disability and mortality. There is currently limited data on the epidemiology of LVO strokes and ET eligibility. We aim to determine the incidence of intracranial vessel occlusion (IVO) strokes eligible for ET per 2018 American Heart Association (AHA) guidelines and characteristics of an AHA ineligible population at a comprehensive stroke center (CSC). Methods: Retrospective chart review of all consecutive AISs at a CSC between November 2014 and February 2017.
Source: Journal of Stroke and Cerebrovascular Diseases - August 9, 2019 Category: Neurology Authors: Shashvat M. Desai, Matthew Starr, Bradley J. Molyneaux, Marcelo Rocha, Tudor G. Jovin, Ashutosh P. Jadhav Source Type: research
Utilization of Intravenous Tissue Plasminogen Activator and Reasons for Nonuse in Acute Ischemic Stroke in Saudi Arabia
Background: Recombinant tissue plasminogen activator (rt-PA, alteplase) within 4.5 hours of symptom onset decreases the rate of disability after acute ischemic stroke (AIS). Due to various reasons, alteplase remains underutilized in certain regions ( ∼3% in low- and middle-income countries). Aims: We aimed to estimate the alteplase utilization rate and identify the reasons for nonuse in Saudi Arabia. Methods: We retrospectively reviewed all patients admitted with suspected stroke in the past 24 hours to the stroke unit at King Abdulaziz Medica l City, Riyadh, Saudi Arabia from February 2016 to July 2018.
Source: Journal of Stroke and Cerebrovascular Diseases - March 11, 2020 Category: Neurology Authors: Ali M. Al Khathaami, Bayan Al Bdah, Maisoun Tarawneh, Mohammed Alskaini, Faris Alotaibi, Abdulaziz Alshalan, Mohammed Almuhraj, Daham Aldaham, Nasser Alotaibi Source Type: research
Knowledge of Stroke, Its Warning Symptoms, Risk Factors and Treatment among the General Public and General Practitioners in a South Asian Population
Despite the recent surge of therapeutic options in treating acute stroke, stroke remains a leading cause of adult mortality and disability.1,2 Late presentation beyond the therapeutic window poses the main obstacle to institute therapeutic reperfusion for acute ischaemic strokes with thrombolysis rates remaining as low as 1%-8% at most.3 Delay in presentation has been attributed to a lack of awareness among the general population of stroke, its risk factors, warning symptoms and treatment in both developed and developing countries.
Source: Journal of Stroke and Cerebrovascular Diseases - March 12, 2020 Category: Neurology Authors: Thashi Chang, Shiyana Ibrahim, Hasanthika M. Ranasinghe, A.H.T.M. Mihirini, Dinushi Weerasinghe, T.D.P. Vithanage, Chinthaka Banagala, Carukshi Arambepola Source Type: research
Serum Neurofilament Light Chain as a Predictive Biomarker for Ischemic Stroke Outcome: A Systematic Review and Meta-analysis
Despite advances in early diagnosis and aggressive management of vascular risk factors, stroke remains the leading cause of death and long-term disability worldwide, and that ischemic stroke accounts for about 85% of all cerebrovascular diseases.1 Only a third of patients who survive an ischemic stroke recovers with minimal or no deficit, whereas the majority remains moderately or severely disabled lifetime.2 With the increasing of life expectancy and aging of the population, care for poststroke patients has become an important social and economic burden.
Source: Journal of Stroke and Cerebrovascular Diseases - April 15, 2020 Category: Neurology Authors: Daoshen Liu, Jing Chen, Xuanying Wang, Jialun Xin, Ruili Cao, Zhirong Liu Source Type: research
Impaired glymphatic system in secondary degeneration areas after ischemic stroke in rats
Ischemic stroke is a major health problem and associated with adverse clinical outcomes like death and disability.1 Neural degeneration of cerebral ischemic stroke is related to not only primary lesions, but also secondary degeneration lesions such as hippocampus, substantia Nigra (SN), thalamus, brain steam, and cortical-spinal tracts in human and rodents.2 –4 However, despite that neural damage, immune cells infiltration and glial activation may contribute to post-stroke secondary degeneration in thalamus, and impairment of the GABAergic system, loss of substance P and inflammation may correlate with secondary degenera...
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2020 Category: Neurology Authors: Luyi Lin, Xiaozhu Hao, Chanchan Li, Chengfeng Sun, Xiaohong Wang, Lekang Yin, Xiaoxue Zhang, Jiaqi Tian, Yanmei Yang Source Type: research
Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model
Stroke is the leading cause of disability and death worldwide,1 but current available therapies are limited.2 Oxidative stress is the major component of the stroke cascade, especially in the acute phase of an ischemic stroke.3,4 During brain ischemia and reperfusion, reactive oxygen species (ROS), also referred to as oxygen free radicals, are overproduced, while the endogenous antioxidative defense systems are disrupted.5 ROS generates toxic aldehyde 4-hydroxynonenal (4-HNE),6 glycated protein N(epsilon)-(carboxymethyl) lysine (CML),7 and oxidized DNA 8-hydroxy-2-deoxyguanosine (8-OHdG).
Source: Journal of Stroke and Cerebrovascular Diseases - May 17, 2020 Category: Neurology Authors: Yuki Taira, Toru Yamashita, Yuting Bian, Jingwei Shang, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Keiichiro Tsunoda, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research
Association between post-stroke disability and 5-year hip-fracture risk: The Women's Health Initiative
We examined predictors of hip fracture risk after stroke using data from the Women's Health Initiative (WHI). In particular, we examined the association between post-stroke disability levels and hip fracture risk.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Carin A. Northuis, Carolyn J. Crandall, Karen L. Margolis, Susan J. Diem, Kristine E. Ensrud, Kamakshi Lakshminarayan Source Type: research
Evaluation of the Effectiveness of Treatment with Botulinum Toxin on Sleep Quality in Stroke-Related Spasticity
Stroke is one of the most common causes of mortality and neurological disability worldwide.1 Spasticity is one of the most common findings of hemiplegia after stroke and the rate of spasticity after stroke is 40%.2 Spasticity is defined as sensory-motor control disorder, arising from intermittent or continuous involuntary activation of muscles resulting from upper motor neuron lesion.3 Although spasticity has benefits such as contributing to standing and walking, preventing osteoporosis, deep vein thrombosis and contributing to blood circulation, it is a complex disorder that causes serious disability in daily life activit...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Hulya Deveci Source Type: research
Determinants of Long-Term Health-Related Quality of Life in Young Ischemic Stroke Patients
The burden of stroke is multidimensional. The most commonly assessed stroke outcomes tend to be mortality and disability, which are physician reported measures. On the other hand, the health-related quality of life (HRQOL) measure evaluates stroke outcomes from the patients ’ perspective. It provides valuable information in that it rates physical, emotional, social, and other domains, and has repeatedly been associated with mortality.1,2
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2020 Category: Neurology Authors: Siim Schneider, Nele Taba, Minni Saapar, Riina Vibo, Janika K õrv Source Type: research
Stroke Research Disparity in Southeast Asia: Socioeconomic Factors, Healthcare Delivery, and Stroke Disease Burden
In recent decades, non-communicable diseases have outpaced communicable diseases as the leading causes of infirmity and loss of life and livelihood. One in four people over age 25 will experience a stroke in their lifetime.1 In low- to low-middle income countries (LMICs), stroke occurs at a younger age compared to high-income countries, contributing to a disproportionate amount of disability-adjusted life years (DALYs) lost and economic liabilities.2,3
Source: Journal of Stroke and Cerebrovascular Diseases - November 27, 2020 Category: Neurology Authors: Almira Doreen Abigail O. Apor, Gerald T. Pagaling, Adrian I. Espiritu, Roland Dominic G. Jamora Source Type: research
Cost Burden and Cost-Effective Analysis of the Nationwide Implementation of the Quality in Acute Stroke Care Protocol in Australia
Stroke is the third global leading cause of death and disability.1,2 In Australia, stroke accounts for 3% of the total burden of disease and 5% of all deaths, with 36,700 incident strokes annually.3 Healthcare expenditure for stroke in Australia in 2017 was AUD 663 million.4
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2021 Category: Neurology Authors: Clara Marquina, Zanfina Ademi, Ella Zomer, Richard Ofori-Asenso, Rhiannon Tate, Danny Liew Source Type: research
Calcium Channel Subunit α2δ-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke
Cerebral infarction (commonly known as ischemic stroke) is a leading cause of morbidity, mortality and disability worldwide. Activation of presynaptic voltage-gated calcium channels (VGCCs) and glutamate release plays a central role in neuronal necrosis after cerebral ischemia.1,2 Previous studies seemed to be encouraging that nimodipine, a dihydropyridine calcium channel antagonist, had a significant benefit in mortality and neurologic outcome in patients with mild stroke or within 12 hours of stroke, although there was still controversial.
Source: Journal of Stroke and Cerebrovascular Diseases - May 25, 2021 Category: Neurology Authors: Xiaoqin Xiong, Linjing Zhang, Yunhui Li, Shuang Guo, Wei Chen, Lijun Huang, Yi Luo Source Type: research
The Distance Covered in Field Tests is more Explained by Walking Capacity than by Cardiorespiratory Fitness after Stroke
Stroke affects approximately 795.000 people each year, with a global prevalence of 104.2 million people.1 Furthermore, stroke is considered a leading cause of long-term disability.1 Individuals after stroke often have walking limitations and reduced cardiorespiratory fitness (CRF).2,3 Walking refers to moving on a surface on foot, step by step.4 Both distance covered and gait speed have been used to inform about walking capacity.5 The CRF informs about the ability of the cardiovascular and respiratory systems to supply blood rich in oxygen and the capacity of the muscular system to use it during sustained physical activity.
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2021 Category: Neurology Authors: Paula da Cruz Peniche, Larissa Tavares Aguiar, Maria Teresa Ferreira dos Reis, Daniela Matos Garcia Oliveira, Paula Luciana Scalzo, Christina Danielli Coelho de Morais Faria Source Type: research
Previous Disability and Benefit of Acute Phase Therapy in Functional Prognosis of Selected Patients with Ischemic Stroke
Patients ’ previous disability (PD) is a key factor when considering acute stroke therapy. PD's exact impact on functional prognosis of patients with acute ischemic stroke remains not entirely clarified. We aimed to analyze PD's influence on functional outcome three months after ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 27, 2021 Category: Neurology Authors: Jos é Lourenço Rosa, Marta Alves, Patrícia Ferreira, Ana Luísa Papoila, Ana Paiva Nunes Source Type: research
Early Wearing of Knee-Ankle-Foot Orthosis Improves Functional Prognosis in Patients after Stroke
After a stroke, patients have reduced mobility and activities of daily living (ADL) due to physical impairment.1 Half of the patients have difficulties in gait in the early stages after stroke, and 50% of patients still have some disability in the chronic phase.2 Gait is associated with activity, participation, and environmental factors that affect the degree of independence in daily living.3,4 Thus, regaining gait ability is the most important goal of rehabilitation for ADL recovery in patients with stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2022 Category: Neurology Authors: Keisuke Sato, Tatsuro Inoue, Keisuke Maeda, Akio Shimizu, Kenta Murotani, Junko Ueshima, Yuria Ishida, Takahiro Ogawa, Masaki Suenaga Source Type: research
