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Coffee Consumption and Stroke Risk: Evidence from a Systematic Review and Meta-Analysis of more than 2.4 Million Men and Women
Stroke remains the leading cause of disability and mortality globally. Based on the Global Burden of Disease Study 2016, it was estimated that there were 13.7 million new stroke cases, 5.5 million deaths, 80.1 million prevalent cases, and 116.4 million disability-adjusted life-years.1 About 75% of stroke cases are ischemic, whereas the remaining cases are hemorrhagic.2 Stroke incidence increases with age. Well-known risk factors for stroke include personal history of hypertension, diabetes and cardiac diseases, unhealthy behavioral factors (heavy cigarette consumption, less physical inactivity, poor diet), and serious environmental risks.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2020 Category: Neurology Authors: Chuan Shao, Hui Tang, Xiaoya Wang, Jiaquan He Source Type: research

Modifiable Factors Associated with Non-Adherence to Secondary Ischaemic Stroke Prevention Strategies
Eighty percent of stroke is due to five modifiable factors: hypertension, smoking, abdominal obesity, unhealthy diet, and lack of exercise.1 Risk factors for first-time and recurrent ischaemic stroke are similar.2 The absolute risk of a recurrent ischaemic stroke following an initial ischaemic stroke is 29.7% by five years.3 Recurrent strokes are associated with greater disability and mortality than first-time strokes.4 Secondary prevention strategies are key in reducing recurrent ischaemic events.
Source: Journal of Stroke and Cerebrovascular Diseases - October 27, 2020 Category: Neurology Authors: G Shankari, Szu Chyi Ng, Si Ying Goh, Fung Peng Woon, Kinjal Doshi, Pei Shieen Wong, Qianqian Fan, Il Fan Tan, Kaavya Narasimhalu, Deidre Anne De Silva Source Type: research

Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model
Stroke is the leading cause of disability and death worldwide,1 but current available therapies are limited.2 Oxidative stress is the major component of the stroke cascade, especially in the acute phase of an ischemic stroke.3,4 During brain ischemia and reperfusion, reactive oxygen species (ROS), also referred to as oxygen free radicals, are overproduced, while the endogenous antioxidative defense systems are disrupted.5 ROS generates toxic aldehyde 4-hydroxynonenal (4-HNE),6 glycated protein N(epsilon)-(carboxymethyl) lysine (CML),7 and oxidized DNA 8-hydroxy-2-deoxyguanosine (8-OHdG).
Source: Journal of Stroke and Cerebrovascular Diseases - May 17, 2020 Category: Neurology Authors: Yuki Taira, Toru Yamashita, Yuting Bian, Jingwei Shang, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Keiichiro Tsunoda, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe Source Type: research

Early Motor-Behavioral Outcome of Ischemic Stroke with Ketogenic Diet Preconditioning: Interventional Animal Study
Background: Cerebral stroke, with ischemic stroke being its most common type, is the leading cause of chronic disability. The ketogenic diet has been used for treating seizures for centuries and has been considered to be a treatment for other neurologic diseases in recent years. The goal of this study is to evaluate the effects of ketogenic diet preconditioning on the early motor-behavior outcome of rats with induced cerebral ischemic stroke. Methods: Twenty-four rats were surveyed in 3 groups of Main, Control, and Sham.
Source: Journal of Stroke and Cerebrovascular Diseases - January 16, 2019 Category: Neurology Authors: Sheida Shaafi, Mirmohsen Sharifi-Bonab, Neda Ghaemian, Mohaddeseh Mokhtarkhani, Hossen Akbari Source Type: research