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Source: Neurochemical Research
Condition: Disability

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Total 30 results found since Jan 2013.

Neuron Specific Enolase and C-reactive Protein Levels in Stroke and Its Subtypes: Correlation with Degree of Disability.
Abstract Stroke is an emergency which threatens life and third leading cause of death and long term disability in developed countries. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of biochemical marker of brain damage neuron-specific enolase (NSE) and systemic inflammatory marker C-reactive protein (CRP) with respect to degree of disability at the time of admission and short term in stroke patients. We investigated 120 patients with cerebrovascular stroke who were admitted within 72 h of onset of s...
Source: Neurochemical Research - May 17, 2014 Category: Neuroscience Authors: Pandey A, Shrivastava AK, Saxena K Tags: Neurochem Res Source Type: research

The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke.
Abstract Ischemic stroke is characterized by high morbidity, mortality and disability rate worldwide. Because of its complexity in pathogenesis and lack of effective therapeutic strategies and drugs, great breakthrough has not yet been made in the treatment of cerebral ischemic stroke. Therefore, to explore a more effective and safer therapeutic strategy for cerebral ischemic stroke has been the focus of numerous researchers. Neuroprotective effects of sonic hedgehog (Shh) signaling pathway in ischemic stroke have been reported in recent studies, but have not been fully elucidated. In our review, we elaborate the ...
Source: Neurochemical Research - September 28, 2018 Category: Neuroscience Authors: Liu L, Zhao B, Xiong X, Xia Z Tags: Neurochem Res Source Type: research

Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke.
Abstract Stroke is the leading cause of serious long-term disability and the fifth leading cause of death in the United States. Treatment options for stroke are few in number and limited in efficacy. Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. Interfering with the inflammation cascade after stroke holds the promise to modulate stroke outcome. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia. KCa3.1 function has been implicated in pro-inflammatory activation of microglia and th...
Source: Neurochemical Research - March 31, 2017 Category: Neuroscience Authors: Staal RG, Weinstein JR, Nattini M, Cajina M, Chandresana G, Möller T Tags: Neurochem Res Source Type: research

< sup > 1 < /sup > H NMR Spectroscopy-Based Metabolomics Approach to Study the Anti-Stroke Activity of G-3702, a Novel Better Alternative to DL-3-n-Butylphthalide
Neurochem Res. 2022 Jun 23. doi: 10.1007/s11064-022-03648-3. Online ahead of print.ABSTRACTCerebrovascular disease is the leading cause of disability and death, and ischemic stroke accounts for most stroke cases. However, few effective drugs are available for the treatment of ischemic stroke; thus, there is an urgent need to develop effective drugs to treat ischemic stroke. DL-3-n-butylphthalide (NBP) is clinically approved as an anti-ischemic drug in China, but its potential hepatotoxicity limits its use. G-3702 (a structural analogue of NBP) is synthesized with the boron hydroxyl group replacing carbonyl group. G-3702 si...
Source: Neurochemical Research - June 23, 2022 Category: Neuroscience Authors: Guanghui Li Lingyu Ruan Huihui Meng Wenya Liu Xinyu Zhong Jinran Yu Lin Zhang Minqiang Zhu Junsong Wang Source Type: research

MiR-182 Inhibition Protects Against Experimental Stroke in vivo and Mitigates Astrocyte Injury and Inflammation in vitro via Modulation of Cortactin Activity
Neurochem Res. 2022 Aug 11. doi: 10.1007/s11064-022-03718-6. Online ahead of print.ABSTRACTIschemic stroke remains a devastating cerebrovascular disease that accounts for a high proportion of mortality and disability worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that are responsible for regulation of post-transcriptional gene expression, and growing evidence supports a role for miRNAs in stroke injury and recovery. The current study examined the role of miR-182 in experimental stroke using both in vitro and in vivo models of ischemic injury. Brain levels of miR-182 significantly increased after transie...
Source: Neurochemical Research - August 11, 2022 Category: Neuroscience Authors: Qasim M Alhadidi Lijun Xu Xiaoyun Sun Yusuf S Althobaiti Atiah Almalki Hashem O Alsaab Creed M Stary Source Type: research

Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage
Neurochem Res. 2022 Nov 3. doi: 10.1007/s11064-022-03789-5. Online ahead of print.ABSTRACTStroke is one of the leading causes of death and long-term serious disability. Current therapeutic strategy is limited to thrombolytic agents, consequently, boosting endogenous neuroprotective mechanisms of the brain to protect itself against harmful stimuli and restore from damages are widely studied. Preconditioned brain to tolerate cerebral ischemia/reperfusion injury could be initiated by several different pharmacological and mechanical strategies, such as ischemic preconditioning, ethanol pharmacological preconditioning and other...
Source: Neurochemical Research - November 3, 2022 Category: Neuroscience Authors: Huajun Yang Chengxuan Qi Fang Su Wei Shan Anchen Guo Jianping Wu Yongjun Wang Hong You Qun Wang Source Type: research

The Role of Circular RNAs in Ischemic Stroke
Neurochem Res. 2023 May 1. doi: 10.1007/s11064-023-03935-7. Online ahead of print.ABSTRACTIschemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to insufficient oxygen supply to the brain, is a major cause of death and physical disability worldwide. Recent research has demonstrated the critical role of circular RNAs (circRNAs), a class of covalently enclosed noncoding RNAs that are widespread in eukaryotic cells, in regulating various physiological and pathophysiological cellular processes, including cell apoptosis, autophagy, synaptic plasti...
Source: Neurochemical Research - May 1, 2023 Category: Neuroscience Authors: Weiwei Jiang Xiongquan Long Zhicheng Li Mi Hu Yangkai Zhang Huiling Lin Wanying Tang Yuxin Ouyang Liping Jiang Jinzhi Chen Pingping He Xinping Ouyang Source Type: research

Tetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGE.
Abstract Ischemic stroke is the most common type of stroke and brings about a big disease burden because of high mortality and disability in China. Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the Chinese herb Radix Stephania tetrandra, has been demonstrated to possess anti-inflammatory and free radical scavenging effects and even regulate astrocyte activation, but the possible role of tetrandrine in ameliorating cerebral ischemia/reperfusion injury of ischemic stroke remains unknown. The aim of this study was to determine the effects of tetrandrine on neurological injury and differential proteomic ...
Source: Neurochemical Research - June 19, 2013 Category: Neuroscience Authors: Ruan L, Huang HS, Jin WX, Chen HM, Li XJ, Gong QJ Tags: Neurochem Res Source Type: research

Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury
Neurochem Res. 2021 Aug 11. doi: 10.1007/s11064-021-03419-6. Online ahead of print.ABSTRACTIschemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset. Loss of function after stroke is due to cell death in the infarcted tissue, cell dysfunction in the peri-infarct region, as well as dysfunction and neurodegeneration in remote brain areas. Plasticity responses in spared brain regions are a major contributor to functional recovery, while secondary neurodegeneration in remote regions is associated wit...
Source: Neurochemical Research - August 11, 2021 Category: Neuroscience Authors: Marcela Pekna Anna Stokowska Milos Pekny Source Type: research