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DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury By Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis
CONCLUSION: Overall, early application of NBP attenuated cerebral ischemia-reperfusion injury by inhibiting mitochondrial Omi/HtrA2-mediated apoptosis in rats. Our study supports a novel neuroprotective mechanism of NBP, making it a promising therapeutic agent for ischemic stroke.PMID:36852812 | DOI:10.2174/1567202620666230228100653
Source: Current Neurovascular Research - February 28, 2023 Category: Neurology Authors: Shuo Huang Qianyan He Xin Sun Yang Qu Reziya Abuduxukuer Jiaxin Ren Kejia Zhang Yi Yang Zhen-Ni Guo Source Type: research

The residual risks associated with atherothrombosis of recurrent ischemic stroke (IS) after non-cardiogenic IS
Curr Neurovasc Res. 2022 Dec 22. doi: 10.2174/1567202620666221222114325. Online ahead of print.ABSTRACTRecurrent ischemic stroke (IS) is one of the leading causes of disability and death worldwide. Patients with recurrent IS, in comparison with survivors of the initial non-cardiogenic IS, have more serious neurological deficit and longer average hospital stay as well as heavier family and socio-economic burden. Therefore, recurrent IS is a major challenge that we urgently need to address. The recurrence rate of non-cardiogenic IS is not zero, and even shows an increasing trend over a long period of time, despite receiving ...
Source: Current Neurovascular Research - December 25, 2022 Category: Neurology Authors: Hengshu Chen Fafa Tian Source Type: research

Analysis of prognostic risk factors for ischaemic stroke in China: A multicentre retrospective clinical study-a national survey in China
CONCLUSIONS: Our study identified sex differences in stroke-related disability, recurrence, and death and attempted to explain the causes of these differences. Our study clearly showed that a large proportion of this difference can be attributed to age, socioeconomic factors, lifestyle habits and medical history, which are confounded by sex, rather than sex per se.PMID:35362370 | DOI:10.2174/1567202619666220331160024
Source: Current Neurovascular Research - April 1, 2022 Category: Neurology Authors: Yuting Cao Ying Chen Xiaoli Li Yongjun Wang Source Type: research

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