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Source: Stroke
Condition: Disability

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Total 122 results found since Jan 2013.

Tenecteplase-Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion Clinical Sciences
Conclusions— Administration of TNK–tissue-type plasminogen activator in minor stroke with intracranial occlusion is both feasible and safe. A larger randomized controlled trial is needed to prove that this treatment is efficacious. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01654445.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Coutts, S. B., Dubuc, V., Mandzia, J., Kenney, C., Demchuk, A. M., Smith, E. E., Subramaniam, S., Goyal, M., Patil, S., Menon, B. K., Barber, P. A., Dowlatshahi, D., Field, T., Asdaghi, N., Camden, M.-C., Hill, M. D., for the TEMPO-1 Investigators Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

High-Dose Simvastatin for Aneurysmal Subarachnoid Hemorrhage: Multicenter Randomized Controlled Double-Blinded Clinical Trial Clinical Sciences
Conclusions— High-dose simvastatin treatment should not be prescribed routinely for aneurysmal subarachnoid hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01077206.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Wong, G. K. C., Chan, D. Y. C., Siu, D. Y. W., Zee, B. C. Y., Poon, W. S., Chan, M. T. V., Gin, T., Leung, M., HDS-SAH Investigators, Zhu, Liang, Tan, Lee, Wong, Chan, Po, Woo, Chan Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Neuroprotectors Clinical Sciences Source Type: research

Hospitalization Within the First Year After Stroke: The Dijon Stroke Registry Clinical Sciences
Conclusions— Stroke survivors are at high risk of hospitalization after the episode, and subsequent admission is associated with poor survival, thus highlighting the need for follow-up interventions after discharge to prevent readmission.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Lainay, C., Benzenine, E., Durier, J., Daubail, B., Giroud, M., Quantin, C., Bejot, Y. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Effect of Alteplase Within 6 Hours of Acute Ischemic Stroke on All-Cause Mortality (Third International Stroke Trial) Clinical Sciences
Conclusions— These exploratory analyses of the third International Stroke Trial (IST-3) trial support improving acute stroke patients’ access to earlier alteplase treatment, treatment of patients with poor prognosis, and further randomized controlled trials in minor stroke to replicate these findings. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN25765518.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Whiteley, W. N., Thompson, D., Murray, G., Cohen, G., Lindley, R. I., Wardlaw, J., Sandercock, P., on behalf of the IST-3 Collaborative Group Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Acute Hospital, Community, and Indirect Costs of Stroke Associated With Atrial Fibrillation: Population-Based Study Clinical Sciences
Conclusions— In our population study, AF-stroke was associated with substantially higher total, acute hospital, nursing home, and general practitioner costs per patient. Targeted programs to identify AF and prevent AF-stroke may have significant economic benefits, in addition to health benefits.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Hannon, N., Daly, L., Murphy, S., Smith, S., Hayden, D., Ni Chroinin, D., Callaly, E., Horgan, G., Sheehan, O., Honari, B., Duggan, J., Kyne, L., Dolan, E., Williams, D., Wiley, M., Kelly, P. J. Tags: Embolic stroke, Primary and Secondary Stroke Prevention, Risk Factors for Stroke Clinical Sciences Source Type: research

Natural History and Outcome After Treatment of Unruptured Intradural Fusiform Aneurysms Clinical Sciences
Conclusions— Nonatherosclerotic fusiform intradural aneurysms have a low risk of adverse outcome within the first few years after diagnosis and remain stable unless symptomatic on presentation or >7 mm in maximum diameter. High risks of treatment should be balanced against this benign natural history. Atherosclerotic aneurysms have a worse natural history and may represent a different disease entity.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Sacho, R. H., Saliou, G., Kostynskyy, A., Menezes, R., Tymianski, M., Krings, T., Radovanovic, I., Terbrugge, K., Rinkel, G. J. E., Willinsky, R. Tags: Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Clinical Sciences Source Type: research

Associations Between Estimated Glomerular Filtration Rate and Stroke Outcomes in Diabetic Versus Nondiabetic Patients Clinical Sciences
Conclusions— Decreased eGFR (<45 mL/min per 1.73 m2) is a strong predictor of all-cause mortality, stroke recurrence, and stroke disability in diabetic and nondiabetic patients with acute stroke. Increased eGFR (≥120 mL/min per 1.73 m2) is associated with all of stroke outcomes in diabetic patients and linked to all-cause mortality in nondiabetic patients.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Luo, Y., Wang, X., Matsushita, K., Wang, C., Zhao, X., Hu, B., Liu, L., Li, H., Liu, G., Jia, Q., Wang, Y., Wang, Y., on behalf of the CNSR Investigators Tags: Cerebrovascular disease/stroke, Risk Factors, Clinical Studies Clinical Sciences Source Type: research

Eligibility and Preference of New Oral Anticoagulants in Patients With Atrial Fibrillation: Comparison Between Patients With Versus Without Stroke Clinical Sciences
Conclusions— Patients enrolled in RCTs are partly representative of patients with AF in clinical practice. When time in therapeutic range and bleeding tendency with warfarin use were considered, the use of new oral anticoagulants was preferred in patients with stroke than in nonstroke patients, but they were more likely to be excluded in RCTs.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Yoon, C. H., Park, Y. K., Kim, S. J., Lee, M.-j., Ryoo, S., Kim, G.-M., Chung, C.-S., Lee, K. H., Kim, J. S., Bang, O. Y. Tags: Other anticoagulants Clinical Sciences Source Type: research

Cost-Effectiveness of Recombinant Tissue-Type Plasminogen Activator Within 3 Hours of Acute Ischemic Stroke: Current Evidence Clinical Sciences
Conclusions— Our analysis supports earlier economic evaluations that r-tPA is a cost-effective method to treat stroke. Appropriate use of r-tPA should be prioritized nationally.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Boudreau, D. M., Guzauskas, G. F., Chen, E., Lalla, D., Tayama, D., Fagan, S. C., Veenstra, D. L. Tags: Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Cervical Arterial Dissections and Association With Cervical Manipulative Therapy: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Conclusions— CD is an important cause of ischemic stroke in young and middle-aged patients. CD is most prevalent in the upper cervical spine and can involve the internal carotid artery or vertebral artery. Although current biomechanical evidence is insufficient to establish the claim that CMT causes CD, clinical reports suggest that mechanical forces play a role in a considerable number of CDs and most population controlled studies have found an association between CMT and VAD stroke in young patients. Although the incidence of CMT-associated CD in patients who have previously received CMT is not well established, an...
Source: Stroke - September 22, 2014 Category: Neurology Authors: Biller, J., Sacco, R. L., Albuquerque, F. C., Demaerschalk, B. M., Fayad, P., Long, P. H., Noorollah, L. D., Panagos, P. D., Schievink, W. I., Schwartz, N. E., Shuaib, A., Thaler, D. E., Tirschwell, D. L., on behalf of the American Heart Association Strok Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Evidence for Stroke Family Caregiver and Dyad Interventions: A Statement for Healthcare Professionals From the American Heart Association and American Stroke Association AHA/ASA Scientific Statement
Stroke is a leading cause of severe, long-term disability. Most stroke survivors are cared for in the home by a family caregiver. Caregiver stress is a leading cause of stroke survivor institutionalization, which results in significant costs to the healthcare system. Stroke family caregiver and dyad intervention studies have reported a variety of outcomes. A critical analysis of 17 caregiver intervention studies and 15 caregiver/stroke survivor dyad intervention studies was conducted to provide evidence-based recommendations for the implementation and future design of stroke family caregiver and dyad interventions.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Bakas, T., Clark, P. C., Kelly-Hayes, M., King, R. B., Lutz, B. J., Miller, E. L., on behalf of the American Heart Association Council on Cardiovascular and Stroke Nursing and the Stroke Council Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

{alpha}4 Integrin Is a Regulator of Leukocyte Recruitment After Experimental Intracerebral Hemorrhage Brief Reports
Conclusions— α4 integrin is an important cell adhesion molecule involved in neuroinflammation after ICH.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Hammond, M. D., Ambler, W. G., Ai, Y., Sansing, L. H. Tags: Animal models of human disease, Acute Cerebral Hemorrhage Brief Reports Source Type: research

Predictors and Biomarkers of Treatment Gains in a Clinical Stroke Trial Targeting the Lower Extremity Clinical Sciences
Conclusions— A multimodal model incorporating behavioral and fMRI measures best predicted treatment-induced changes in gait velocity in a clinical trial setting. Results also suggest potential use of fMRI measures as biomarkers of treatment gains.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Burke, E., Dobkin, B. H., Noser, E. A., Enney, L. A., Cramer, S. C. Tags: Exercise/exercise testing/rehabilitation, Other Treatment, Behavioral Changes and Stroke, Computerized tomography and Magnetic Resonance Imaging, Rehabilitation, Stroke Clinical Sciences Source Type: research

Community-Based Stroke System of Care for Chinese Rural Areas Clinical Sciences
Conclusions— A stroke system of care would be reliable and practical in Chinese rural areas. Clinical Trial Registration— URL: http://www.chictr.org. Unique identifier: ChiCTR-RCH-13003408.
Source: Stroke - July 28, 2014 Category: Neurology Authors: He, M., Wang, J., Gong, L., Dong, Q., Ji, N., Xing, H., Zhou, Y., Qin, S., Wang, H., Zhang, H., Hui, R., Wang, Y. Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Randomized Controlled Trial on Hemifield Eye Patching and Optokinetic Stimulation in Acute Spatial Neglect Brief Reports
Conclusions— An early intervention of combined hemifield eye patching and optokinetic stimulation in acute stroke patients with spatial neglect has no additive effect to the spontaneous remitting course of the disorder. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01617343.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Machner, B., Konemund, I., Sprenger, A., von der Gablentz, J., Helmchen, C. Tags: Behavioral/psychosocial - treatment Brief Reports Source Type: research