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Early Initiation of Exoskeletal Robotic Gait Training Improves Functional Outcomes in the Patients with Stroke: A Retrospective Observational Study
Conclusions: In conclusion, early initiation of gait training using HAL might improve the motor function of the paralyzed lower limb and disability in patients with stroke.Eur Neurol
Source: European Neurology - December 14, 2022 Category: Neurology Source Type: research

Treatments in Ischemic Stroke: Current and Future
Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well as strategies able to improve ischemic stroke management from the pre-hospital setting is needed.Summary: The pathophysiology of ischemic stroke involves multiple pathways resulting in cerebral artery obstruction and brain tissue ischemia. To date, the only approved drug for acute ischemic stroke is intravenous thrombolytic alt...
Source: European Neurology - August 2, 2022 Category: Neurology Source Type: research

Prestroke Statins Improve Prognosis of Atrial Fibrillation-Associated Stroke through Increasing Suppressor of Cytokine Signaling-3 Levels
Conclusion: Our data suggested that the prestroke use of statins improved the clinical outcomes in AIS patients with AF by upregulating the level of SOCS-3 and reducing the plasma MMP-9 level.Eur Neurol
Source: European Neurology - March 8, 2021 Category: Neurology Source Type: research

Inhibition of LncRNA MALAT1 Attenuates Cerebral Ischemic Reperfusion Injury via Regulating AQP4 Expression
Stroke is one of the leading causes of mortality and disability worldwide. Long noncoding RNAs (lncRNAs) including MALAT1 have been shown to have critical roles in cerebral ischemia reperfusion injury (CIRI). However, the underlying mechanism of MALAT1 in CIRI has not been elucidated. The present study aimed to investigate the function and potential regulatory mechanism of MALAT1 in cerebral ischemic reperfusion injury. We established the middle cerebral artery occlusion (MCAO) model and oxygen-glucose deprivation/reoxygenation (OGD/RX) model in vivo and in vitro, and then Cell Counting Kit-8 (CCK-8), RT-qPCR, flow cytomet...
Source: European Neurology - October 30, 2020 Category: Neurology Source Type: research

Predictable Value of Functional Independence Measure Differs between Anterior and Posterior Circulation Ischemic Strokes
Conclusions: The differences in outcome predictability by FIM score between AC and PC strokes should be considered, although FIM scores at discharge from stroke unit were useful to predict a favorable outcome.Eur Neurol 2018;80:313 –320
Source: European Neurology - March 21, 2019 Category: Neurology Source Type: research

Inflammatory Signaling in Post-Stroke Fatigue and Depression
Background: In the United States, stroke continues to be the cause for long-term disability. Of the patients with a first stroke, up to 75% will experience post-stroke fatigue (PSF) in the first year following stroke. PSF is one of the most disabling symptoms in stroke survivors; it decreases quality of life, increases mortality, and is a barrier to stroke rehabilitation. Given the incidence of stroke and the prevalence and detrimental impact of PSF on quality of life, independent living, and overall survival, efficient management of PSF must be a priority in stroke rehabilitation. The cause of PSF remains unknown. The bur...
Source: European Neurology - November 16, 2018 Category: Neurology Source Type: research

The Impact of Tumor Necrosis Factor- α and Interleukin-1β Levels and Polymorphisms on Long-Term Stroke Outcomes
Conclusions: These data provide evidence that serum TNF- α and IL-1β concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles.Eur Neurol 2018;79:38 –44
Source: European Neurology - November 21, 2017 Category: Neurology Source Type: research

Thalamic Lesions Caused by Deep Cerebral Venous Thrombosis: A Retrospective Study
Conclusion: Thalamic lesion can be caused by DCVT with neuropsychological and radiological features that should be considered in the differential diagnosis of intracranial artery occlusion or bleeding, especially in young patients. In this small group, most patients survived with few or mild defects.Eur Neurol 2015;74:118-126
Source: European Neurology - September 9, 2015 Category: Neurology Source Type: research

Stroke Unit Management and Revascularisation in Acute Ischemic Stroke
This article examines the current treatment options for stroke patients, summarizing the key clinical evidence, as well as listing the complications and practical issues related to each of these main treatment options. Key Messages: Recent advances in the treatment of acute stroke include developments in intravenous thrombolysis (IVT), intra-arterial treatment and bridging therapies. Clinical Implications: Treatment within a stroke unit reduces mortality and disability regardless of age, sex and stroke severity. IVT is widely available and reduces disability when initiated within 4.5 h after the onset of symptoms. The majo...
Source: European Neurology - November 18, 2014 Category: Neurology Source Type: research