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Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis
Discussion Our main finding is that LAG-3 and TIM-3 expression levels in the PBMCs of MS patients can aid to predict disease outcome. Lower LAG-3 and TIM-3 expression were associated with the worst outcome and increased likelihood to progress to SPMS, while higher LAG-3 and TIM-3 expression correlated significantly with benign prognosis, persisting RRMS, and lower EDSS score at 10 years after blood sampling. Analysis of the paraclinical and clinical parameters baseline brain MRI T2LV, EDSS at diagnosis, and 1-year progression index combined with LAG-3 and TIM-3 expression levels resulted in superior ability to identify pa...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Immune-Mediated Necrotizing Myopathy
AbstractPurpose of ReviewImmune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by relatively severe proximal weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy, and infrequent extra-muscular involvement. Here, we will review the characteristics of patients with IMNM.Recent FindingsAnti-signal recognition particle (SRP) and anti-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies are closely associated with IMNM and define unique subtypes of patients. Importantly, the new European Neuromuscular Centre criteria recognize anti-SRP myopathy, ant...
Source: Current Rheumatology Reports - March 26, 2018 Category: Rheumatology Source Type: research