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Fibrin to von Willebrand factor ratio in arterial thrombi is associated with plasma levels of inflammatory biomarkers and local abundance of extracellular DNA
The composition of thrombi determines their structure, mechanical stability, susceptibility to lysis, and consequently, the clinical outcome in coronary artery disease (CAD), acute ischemic stroke (AIS), and peripheral artery disease (PAD). Fibrin forms the primary matrix of thrombi intertwined with DNA, derived from neutrophil extracellular traps (NETs), and von Willebrand factor (VWF) bridging DNA and platelets. Here we examined the relative content of fibrin, DNA and VWF in thrombi and analyzed their interrelations and quantitative associations with systemic biomarkers of inflammation and clinical characteristics of the patients.
Source: Thrombosis Research - November 17, 2021 Category: Hematology Authors: Erzs ébet Tóth, László Beinrohr, István Gubucz, László Szabó, Kiril Tenekedjiev, Natalia Nikolova, Anikó I. Nagy, László Hidi, Péter Sótonyi, István Szikora, Béla Merkely, Krasimir Kolev Source Type: research

In silico features of ADAMTS13 contributing to plasmatic ADAMTS13 levels in neonates with congenital heart disease
Risk factors contributing to heightened thrombosis in pediatric congenital heart disease (CHD) patients are not fully understood. Among the neonatal CHD population, those presenting with single ventricular physiology are at the highest risk for perioperative thrombosis. The von Willebrand factor and ADAMTS13 interactions have emerged as causative risk factors for pediatric stroke and could contribute to heightened thrombosis in CHD neonates.
Source: Thrombosis Research - May 30, 2020 Category: Hematology Authors: Upendra K. Katneni, David D. Holcomb, Nancy E. Hernandez, Nobuko Hamasaki-Katagiri, Ryan C. Hunt, Haim Bar, Juan C. Ibla, Chava Kimchi-Sarfaty Tags: Full Length Article Source Type: research

P13. Abstract Title: Deep Mutational Scan of VWF to Define Mutations that Enhance or Impair Secretion
Von Willebrand Factor (VWF) is a multimeric glycoprotein that recruits platelets to sites of blood vessel injury and serves as a molecular chaperone for coagulation factor VIII (fVIII). Plasma VWF levels are a known risk factor for various thrombotic disorders including VTE, myocardial infarction, and stroke. GWAS studies have identified genetic variants in VWF that contribute to increased and decreased circulating VWF antigen levels. However, it is currently not known why some variants result in high VWF levels while others cause low VWF levels in circulation.
Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: T. Sparring, C. Kretz, K. Singh, H. Madarati Source Type: research

P7. Abstract Title: Mapping the Interactome of the Metalloprotease ADAMTS13 in Plasma using In-Vitro BioID
Von Willebrand Factor (VWF) is a multimeric plasma protein that tethers platelets to sites of vascular damage, and is an important initiator of blood clotting. ADAMTS13 is a metalloprotease that cleaves VWF to regulate its platelet binding activity. Decreased activity of ADAMTS13 leads to larger VWF multimers resulting in pathological blood clots, such as thrombotic thrombocytopenic purpura (TTP) and stroke. Unlike other circulating proteases, ADAMTS13 is secreted as an active enzyme and is resistant to all known natural protease inhibitors.
Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: H. Madarati, C. Kretz Source Type: research

Association between fibrinogen and fibrinogen γ’ and atherosclerotic plaque morphology and composition in symptomatic carotid artery stenosis: Plaque-At-RISK study
Von Willebrand Factor (VWF), ADAMTS13, fibrinogen and fibrinogen γ’ are associated with an increased risk of ischemic stroke. Carotid atherosclerosis is an important risk factor for ischemic stroke. Characteristics of the vulnerable plaque; intraplaque hemorrhage (IPH), plaque ulceration and lipid-rich necrotic core (LRNC) can be visualized with imaging techni ques. Since atherosclerosis might attribute to the association between coagulation factors and ischemic stroke risk, the aim of this study is to investigate the association between coagulation factors and atherosclerotic plaque characteristics in more detail.
Source: Thrombosis Research - February 27, 2019 Category: Hematology Authors: A.C. van Dijk, S.J. Donkel, T. Zadi, M.A.H. Sonneveld, F.H.B.M. Schreuder, M.F. Chohan, P.J. Koudstaal, F.W.G. Leebeek, R. Saxena, J. Hendrikse, M.E. Kooi, A. van der Lugt, M.P.M. de Maat Tags: Full Length Article Source Type: research

Association of von Willebrand factor deficiency with prevalent cardiovascular disease and asymptomatic carotid atherosclerosis: The Atherosclerosis Risk in Communities Study
Von Willebrand factor (VWF), a large multimeric glycoprotein, plays a critical role in hemostasis. It binds to subendothelial collagen at the site of vascular injury where it facilitates platelet activation. Given the role of VWF in platelet activation, and the role of platelets in cardiovascular events, such as myocardial infarction (MI) and ischemic stroke, VWF may influence the risk of cardiovascular disease (CVD). In addition, evidence suggests that VWF may affect CVD risk by playing a role in atherogenesis by direct participation in plaque formation [1].
Source: Thrombosis Research - May 31, 2016 Category: Hematology Authors: Craig D. Seaman, Kristen M. George, Margaret Ragni, Aaron R. Folsom Source Type: research

D-dimer relates positively with increased blood pressure in black South Africans: The SABPA study
Conclusion: The black population had a more prothrombotic profile, with higher levels of coagulation markers and inhibited fibrinolysis, than the white study participants. The positive association between blood pressure and elevated D-dimer in the blacks may contribute to the high prevalence of hypertension and related increased cardiovascular and cerebrovascular risk in this group.
Source: Thrombosis Research - April 8, 2014 Category: Hematology Authors: Leandi Lammertyn, Aletta E. Schutte, Marlien Pieters, Rudolph Schutte Tags: Coagulation and Fibrinolysis Source Type: research

The Clinical Implications of ADAMTS13 Function: The Perspectives of Haemostaseologists
This article reviews the literature in these conditions.
Source: Thrombosis Research - September 19, 2013 Category: Hematology Authors: Savita Rangarajan, Craig Kessler, Louis Aledort Tags: Mini-Reviews Source Type: research