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Source: Journal of the Neurological Sciences
Condition: Atrial Fibrillation
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Total 45 results found since Jan 2013.
High-sensitivity cardiac troponin T levels and risk of cerebral microbleeds in acute ischemic stroke patients with atrial fibrillation and/or rheumatic heart disease
Elevated high-sensitivity cardiac troponin T (hs-cTnT) levels are associated with coronary disease and small-vessel ischemic stroke through their associations with atherosclerosis. Considering the relationship between atherosclerosis and cerebral microbleeds (CMBs), the purpose of this study was to examine associations between serum hs-cTnT levels and risk of CMBs in acute ischemic stroke patients.
Source: Journal of the Neurological Sciences - August 1, 2016 Category: Neurology Authors: Junfeng Liu, Deren Wang, Yao Xiong, Bian Liu, Chenchen Wei, Zhenxing Ma, Bo Wu, Hehan Tang, Ming Liu Source Type: research
Differentiation of cancer from atrial fibrillation in patients with acute multifocal stroke
Objective.Acute multifocal embolic infarction (AMEI) is conventionally caused by etiologies such as cardioembolism due to atrial fibrillation (Af), but can also be caused by serious underlying diseases such as cancer. We characterized cancer-related AMEI and identified useful indicators for cancer-associated strokes.
Source: Journal of the Neurological Sciences - July 26, 2016 Category: Neurology Authors: Shinji Ito, Akihiro Ueda, Kenichiro Murate, Seiko Hirota, Takao Fukui, Tomomasa Ishikawa, Sayuri Shima, Chika Hikichi, Yasuaki Mizutani, Madoka Kizawa, Kunihiko Asakura, Tatsuro Mutoh Source Type: research
Phosphodiesterase4D (PDE4D) — A risk factor for atrial fibrillation and stroke?
Mutations in the gene encoding phosphodiesterase 4D (PDE4D) enzyme are associated with ischemic stroke; however the functional implications of such mutations are not well understood. PDE4D is part of a complex protein family modulating intracellular signalling by cyclic nucleotides. The PDE4 family includes subtypes A–D, all of which show unique intracellular, cellular and tissue distribution. PDE4D is the major subtype expressed in human atrial myocytes and involved in the pathophysiology of arrhythmias, such as atrial fibrillation.
Source: Journal of the Neurological Sciences - November 5, 2015 Category: Neurology Authors: Carina Jørgensen, Saiqa Yasmeen, Helle K. Iversen, Christina Kruuse Tags: Review article Source Type: research
Impact of dabigatran on platelet function and fibrinolysis
We sought to evaluate the potential enhanced fibrinolytic and antiplatelet activity of dabigatran etexilate (DE) due to decreased thrombin levels in patients with stroke or transient ischemic attack and non-valvular atrial fibrillation (NVAF).
Source: Journal of the Neurological Sciences - July 22, 2015 Category: Neurology Authors: Argirios E. Tsantes, Elias Kyriakou, Stefanos Bonovas, Maria Chondrogianni, Christina Zompola, Chrissoula Liantinioti, Athina Simitsi, Aristeidis H. Katsanos, Maria Atta, Ignatios Ikonomidis, Violetta Kapsimali, Petros Kopterides, Georgios Tsivgoulis Source Type: research
Left atrial dilatation is associated with severe ischemic stroke in men with non-valvular atrial fibrillation
and aim Increased left atrial volume is an independent predictive factor of first ischemic stroke and other cardiovascular events in patients with non-valvular atrial fibrillation (NVAF). However, correlations between left atrial dilatation and ischemic stroke severity or ischemic lesion pattern have not been previously reported. The aim of this study was to evaluate whether left atrial enlargement is associated with worse initial stroke severity and lesion patterns.
Source: Journal of the Neurological Sciences - May 13, 2015 Category: Neurology Authors: Tae-Won Kim, Sung-Woo Jung, In-Uk Song, Jaseong Koo, Hyun Seok Choi, Kwang-Soo Lee, Jeong-Wook Park, Hun-Jun Park, Joong-Seok Kim Source Type: research
Rivaroxaban presents a better pharmacokinetic profile than dabigatran in an obese non-diabetic stroke patient
Novel oral anticoagulants (NOACs) are the recent therapeutic breakthrough in the thromboprophylaxis of non-valvular atrial fibrillation (NVAF). There are currently three different molecules approved for NVAF: dabigatran, rivaroxaban and apixaban. All three agents have demonstrated at least non-inferiority at major clinical endpoints compared to warfarin with their major advantage being the fixed-dose regimen that necessitates no regular blood tests and protects patients from the disastrous effects of infra-therapeutic (embolism) or supra-therapeutic (hemorrhage) anticoagulation.
Source: Journal of the Neurological Sciences - September 14, 2014 Category: Neurology Authors: Apostolos Safouris, Anne Demulder, Nikos Triantafyllou, Georgios Tsivgoulis Tags: Letter to the Editor Source Type: research
Cardioembolic stroke in a patient taking Dabigatran Etexilate: The first case report of clinical and pharmacologic resistance
Dabigatran Etexilate (DE) was the first oral direct thrombin inhibitor approved for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF) [1,2]. One of its main advantages relies on predictable pharmacokinetics allowing a fixed dosage for each patient. In fact, although a range of pharmacokinetic response to DE has been demonstrated, up until now no case has been described of clinical and pharmacologic resistance.
Source: Journal of the Neurological Sciences - August 29, 2014 Category: Neurology Authors: João Sargento-Freitas, Fernando Silva, João Pego, Cristina Duque, Gustavo Cordeiro, Luís Cunha Tags: Letter to the Editor Source Type: research
Cardiac diastolic dysfunction predicts in-hospital mortality in acute ischemic stroke with atrial fibrillation
Conclusion: Diastolic dysfunction may be associated with in-hospital death in ischemic stroke patients with atrial fibrillation.Highlights:
Source: Journal of the Neurological Sciences - July 14, 2014 Category: Neurology Authors: Yohei Tateishi, Akira Tsujino, Jumpei Hamabe, Akira Tsuneto, Koji Maemura, Osamu Tasaki, Nobutaka Horie, Tsuyoshi Izumo, Kentaro Hayashi, Izumi Nagata Tags: Original Articles Source Type: research
Risk factors and etiological subtype analysis of brainstem infarctions
Abstract: Objective: To evaluate the features of risk factors and etiological subtypes of brainstem infarctions (BSIs) patients in China.Methods: One hundred and ninety-nine cerebral infarction patients with brainstem involvement were categorized into five groups according to Trial of Org 10172 in Acute Stroke Treatment classification: large artery disease (LAD), cardioembolism (CE), small vessel disease (SVD), stroke of other determined etiology (SOE) or stroke of undetermined etiology (SUE). The risk factors and percentage of the different etiological subtypes were assessed.Result: A total of 199 patients were enrolled i...
Source: Journal of the Neurological Sciences - January 10, 2014 Category: Neurology Authors: Yinyao Lin, Lei Zhang, Jian Bao, Bingjun Zhang, Haiyan Li, Suqin Chen, Shaoyang Sun, Xuejiao Men, Zhengqi Lu Tags: Original Articles Source Type: research
Significance of acute multiple infarcts in multiple cerebral circulations on initial diffusion weighted imaging in stroke patients
Conclusions: AMIMCC are not rare and mostly need MRI to be detected. Multiple and various etiologies are implicated, including cardioembolic diseases in half of them, but also hematologic disorders and angeitis.
Source: Journal of the Neurological Sciences - December 13, 2013 Category: Neurology Authors: S. Depuydt, M. Sarov, C. Vandendries, T. Guedj, C. Cauquil, P. Assayag, O. Lambotte, D. Ducreux, C. Denier Tags: Original Articles Source Type: research
Ischemic stroke in patients with atrial fibrillation receiving oral anticoagulation
Abstract: Background: Atrial fibrillation is the most common cause of embolic stroke associated to heart disease. Oral anticoagulation with vitamin K antagonists substantially reduces this risk.Aims: We assessed a group of patients with prior diagnosis of atrial fibrillation who sustained an ischemic stroke while receiving an adequate regime of oral anticoagulation.Methods: We evaluated consecutive patients with ischemic stroke and prior diagnosis of atrial fibrillation. We determined demographics, clinical characteristics, TOAST stroke subtypes, CHADS2 scores, and prior or concomitant use of oral anticoagulants.Results: W...
Source: Journal of the Neurological Sciences - September 20, 2013 Category: Neurology Authors: Virginia A. Pujol Lereis, Sebastian Ameriso, Guillermo P. Povedano, Sebastián F. Ameriso Tags: Original Articles Source Type: research
Early initiation of new oral anticoagulants in acute stroke and TIA patients with nonvalvular atrial fibrillation
Conclusions: The NOAC may be safe in acute stroke or TIA patients with NVAF. A large, prospective study is needed to confirm this.
Source: Journal of the Neurological Sciences - June 5, 2013 Category: Neurology Authors: Kensaku Shibazaki, Kazumi Kimura, Junya Aoki, Naoki Saji, Kenichiro Sakai Tags: Original Articles Source Type: research
CHADS2 score predicts functional outcome of stroke in patients with a history of coronary artery disease
Abstract: Background: The aim of this study was to evaluate the efficacy of the CHADS2 scoring system as a prognostic tool for stroke patients with a prior history of coronary artery disease (CAD).Methods: We enrolled 148 acute ischemic stroke patients (mean age, 74.2years; males, 77.0%) with a history of CAD. Pre-admission CHADS2 scores were calculated by assigning a single point for the presence of congestive heart failure, hypertension, age ≥75years, and diabetes; and assigning 2 points for a prior history of stroke or transient ischemic attack. Comparisons were made between patients with poor and good 3-month functio...
Source: Journal of the Neurological Sciences - May 28, 2013 Category: Neurology Authors: Takao Hoshino, Kentaro Ishizuka, Satoru Shimizu, Shinichiro Uchiyama Tags: Original Articles Source Type: research
Reservations against new oral anticoagulants after stroke and cerebral bleeding
Abstract: Dabigatran, rivaroxaban, and apixaban are the new oral anticoagulants (NOAC) which have been investigated in patients with atrial fibrillation (AF) for primary and secondary prevention of stroke and thromboembolism. In these trials NOAC had a similar efficacy and safety profile compared to traditional vitamin-K-antagonists such as warfarin. We advise caution in the use of NOAC in patients with stroke or cerebral hemorrhage because of the following reasons:1) Patients with cerebral bleeding were excluded from the trials. 2) Stroke within 14days and severe stroke within 6months before screening were exclusion crite...
Source: Journal of the Neurological Sciences - April 29, 2013 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Opinion Source Type: research
A simple score for predicting paroxysmal atrial fibrillation in acute ischemic stroke
Conclusion: Our simple score can predict the presence of PAF during hospitalization in acute ischemic stroke.
Source: Journal of the Neurological Sciences - March 25, 2013 Category: Neurology Authors: Shuichi Fujii, Kensaku Shibazaki, Kazumi Kimura, Kenichiro Sakai, Junya Aoki Tags: Original Articles Source Type: research
