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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Atrial Fibrillation
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Total 320 results found since Jan 2013.
The Use of Oral Anticoagulants in Patients with Atrial Fibrillation in the Emergency Department
Atrial Fibrillation is the leading cause of embolic stroke, yet less than half of high-risk patients with atrial fibrillation are on adequate stroke prevention with oral anticoagulants. Guidelines for the primary prevention of stroke recognize the emergency department as a location for physicians to identify atrial fibrillation and initiate anticoagulants. We sought to compare anticoagulant prescription rates in patients with atrial fibrillation in various provider settings to identify opportunities for improvement in cardioembolic stroke prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - January 26, 2020 Category: Neurology Authors: Hope Hua, Nicole Sur, Jungwon Choi, Sai Polineni, Lilly Lee, Seemant Chaturvedi Source Type: research
Clinical Risk Factors of Thromboembolic and Major Bleeding Events for Patients with Atrial Fibrillation Treated with Rivaroxaban in Japan
Background: It is important to understand the risk of thromboembolism and bleeding in patients with nonvalvular atrial fibrillation (NVAF) receiving direct oral anticoagulants; however, data on risk factors in Japanese patients are limited. Methods: XAPASS (Xarelto Post-Authorization Safety and Effectiveness Study in Japanese Patients with Atrial Fibrillation) is a prospective observational study examining the safety and effectiveness of rivaroxaban in Japanese real-world clinical practice. We investigated risk factors for stroke/noncentral nervous system systemic embolism (non-CNS SE)/myocardial infarction (MI) and major ...
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2020 Category: Neurology Authors: Susumu Miyamoto, Takanori Ikeda, Satoshi Ogawa, Takanari Kitazono, Jyoji Nakagawara, Kazuo Minematsu, Yuji Murakawa, Sanghun Iwashiro, Makiko Takeichi, Yoko Kidani, Yutaka Okayama, Toshiyuki Sunaya, Shoichiro Sato, Satoshi Yamanaka Source Type: research
Supraventricular Extrasystoles on Standard 12-lead Electrocardiogram Predict New Incident Atrial Fibrillation after Embolic Stroke of Undetermined Source: The AF-ESUS Study
Background: The diagnosis of covert atrial fibrillation (AF) remains a major challenge to guide secondary prevention of patients with embolic stroke of undetermined source (ESUS). Aims: We analyzed consecutive ESUS patients from 3 prospective stroke registries to assess whether the presence of supraventricular extrasystoles (SVE) on standard 12-lead electrocardiogram (ECG) is associated with the detection of AF (primary outcome), stroke recurrence and death (secondary outcomes) during follow-up.
Source: Journal of Stroke and Cerebrovascular Diseases - January 14, 2020 Category: Neurology Authors: George Ntaios, Kalliopi Perlepe, Dimitrios Lambrou, Gaia Sirimarco, Davide Strambo, Ashraf Eskandari, Efstathia Karagkiozi, Anastasia Vemmou, Eleni Koroboki, Efstathios Manios, Konstantinos Makaritsis, Patrik Michel, Konstantinos Vemmos Source Type: research
Risk of Ischemic Stroke and Major Bleeding in Patients With Atrial Fibrillation and Cancer
Background: Atrial fibrillation (AF) is an important risk factor for ischemic stroke. Cancer may increase the risk both of ischemic stroke and of bleeding. Less is known about risk of ischemic stroke and bleeding among cancer patients with AF, complicating the prevention of ischemic stroke in these patients. Methods: Register based cohort study comprising all Swedish patients hospitalized with a primary diagnosis of AF from July 1, 2005 until December 31, 2014. Patients with cancer diagnosis were compared to the rest of the cohort.
Source: Journal of Stroke and Cerebrovascular Diseases - December 26, 2019 Category: Neurology Authors: Sara Aspberg, Liyang Yu, Bruna Gigante, Karin E Smedby, Daniel E Singer Source Type: research
Response to the letter by Drs. Lattanzi and Silvestrini Re: Prevalence of Nonstenotic Carotid Plaque in Stroke Due to Atrial Fibrillation Compared to Embolic Stroke of Undetermined Source
We appreciate the thoughtful feedback regarding our manuscript by Drs. Lattanzi and Silvestrini. We agree that serologic and physiologic biomarkers of other occult stroke mechanisms would add to our understanding and management of these patients. In regard to occult cardiac sources of embolism, elevations in the brain natriuretic peptide,1 and larger P-wave terminal force (PWTF)2 or left atrial diameter3 are increasingly thought to be markers of a prothrombotic cardiopathy. As previously shown by Dr.
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2019 Category: Neurology Authors: James E. Siegler, Jesse M. Thon Tags: Letter to the Editor Source Type: research
Burden of Premature Atrial Complexes and Risk of Recurrent Stroke and Death in Patients with Mild to Moderate Ischemic Stroke
Premature atrial complexes (PACs) meet increased attention as a potential intermediary between sinus rhythm and atrial fibrillation (AF). Patients with even high numbers of PACs do not fulfill current guidelines for oral anticoagulation treatment though an associated stroke risk is suspected. Objective: We aimed to determine whether a high number of PACs or runs of AF less than 30 seconds in 2-day continuous electrocardiogram (ECG) recording was associated with risk of recurrent ischemic stroke/transient ischemic attack (TIA) or death in a large cohort of patients with acute ischemic stroke or TIA and no prior AF.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2019 Category: Neurology Authors: Michala Herskind Sejr, Ole May, Dorte Damgaard, Niels Henrik Bruun, Jens Cosedis Nielsen Source Type: research
Letter to the Editor regarding “Prevalence of Nonstenotic Carotid Plaque in Stroke due to Atrial Fibrillation Compared to Embolic Stroke of Undetermined Source”
This study can provide stimulating cues to understand the pathophysiology underpinning ESUS, and the interpretation of findings may be enhanced by the following considerations.
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2019 Category: Neurology Authors: Simona Lattanzi, Mauro Silvestrini Tags: Letter to the Editor Source Type: research
Impaired Endothelial Function in Embolic Stroke of Undetermined Source
This study aimed to clarify the endothelial function of patients with ESUS.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2019 Category: Neurology Authors: Yuka Shirai, Sono Toi, Utako Adachi, Kazuo Kitagawa Source Type: research
Multicenter prospective analysis of stroke patients taking oral anticoagulants: The PASTA registry - Study design and characteristics
The management of atrial fibrillation and deep venous thrombosis has evolved with the development of direct oral anticoagulants (DOAC), and oral anticoagulant (OAC) might influence the development or clinical course in both ischemic and hemorrhagic stroke. However, detailed data on the differences between the effects of the prior prescription of warfarin and DOAC on the clinical characteristics, neuroradiologic findings, and outcome of stroke are limited.
Source: Journal of Stroke and Cerebrovascular Diseases - October 28, 2019 Category: Neurology Authors: Satoshi Suda, Yasuyuki Iguchi, Shigeru Fujimoto, Yoshiki Yagita, Yu Kono, Masayuki Ueda, Kenichi Todo, Tomoyuki Kono, Takayuki Mizunari, Mineo Yamazaki, Takao Kanzawa, Seiji Okubo, Kimito Kondo, Nobuhito Nakajima, Takeshi Inoue, Takeshi Iwanaga, Makoto Na Source Type: research
Effect of Known Atrial Fibrillation and Anticoagulation Status on the Prehospital Identification of Large Vessel Occlusion
Introduction: The Cincinnati Prehospital Stroke Severity scale (C-STAT), Los Angeles Motor Scale (LAMS), Rapid Arterial Occlusion Evaluation (RACE) score, and Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scales were designed to aid emergency responder identification of patients with stroke related to large vessel occlusion (LVO). We hypothesized that the addition of a known history of atrial fibrillation (AF) without anticoagulation to currently used scales would improve LVO detection.
Source: Journal of Stroke and Cerebrovascular Diseases - September 25, 2019 Category: Neurology Authors: Parneet Grewal, Sourabh Lahoti, Sushanth Aroor, Kaitlin Snyder, Luther C. Pettigrew, Larry B. Goldstein Source Type: research
Long-Term Follow-Up of Cerebral Amyloid Angiopathy-Associated Intracranial Hemorrhage Reveals a High Prevalence of Atrial Fibrillation
Goal: Cerebral amyloid angiopathy (CAA) is the second-most common cause of nontraumatic intracerebral hemorrhages (ICH), surpassed only by uncontrolled hypertension. We characterized the percentage, risk factors, and comorbidities of patients suffering from CAA-related ICH in relation to long-term outcomes. Material and Methods: We performed retrospective analyses and clinical follow-ups of individuals suffering from ICH who were directly admitted to neurosurgery between 2002 and 2016. Findings: Seventy-four of 174 (42%) spontaneous nontraumatic lobar ICH cases leastwise satisfied the modified Boston criteria definition fo...
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2019 Category: Neurology Authors: Johanna Kaiser, Karl-Michael Schebesch, Alexander Brawanski, Ralf A. Linker, Felix Schlachetzki, Andrea Wagner Source Type: research
Comorbid Atrial Fibrillation in Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage: Between a Rock and a Hard Place
Atrial fibrillation (AF) and intracerebral hemorrhage (ICH), including cerebral amyloid angiopathy (CAA)-related ICH, are age-related conditions that additionally share hypertension as a common risk factor. A Spanish population-based study reported a 50% increase in the prevalence of AF in ICH patients between 2003 (10.5%) and 2012 (15.5%).1 The prevalence of AF and ICH, and their ensuing comorbidity, are expected to continue increasing with global aging demographics.
Source: Journal of Stroke and Cerebrovascular Diseases - September 4, 2019 Category: Neurology Authors: Ashkan Shoamanesh, Andreas Charidimou, Kevin N. Sheth Source Type: research
The Value of the CHADS2 and CHA2DS2-VASc Score for Predicting the Prognosis in Lacunar Stroke with or without Atrial Fibrillation Patients
Background: The CHADS2 and CHA2DS2-VASc scoring systems have been proved efficacy to stratify stroke and thromboembolism risk in patients with atrial fibrillation (AF). Whether CHADS2 and CHA2DS2-VASc score has predictive value for the prognosis in lacunar stroke (LS) patients remains unclear. Methods: A total of 763 consecutive patients with LS (mean age: 66 ± 12 years; 464 male) were enrolled in this study between January 2013 and December 2014. Patients were divided into LS without AF (LS; n = 679) and LS with AF (LS-AF; n = 84) groups.
Source: Journal of Stroke and Cerebrovascular Diseases - August 29, 2019 Category: Neurology Authors: Hong-Jie Yang, Guang-Ji Wang, Wei Shuai, Cai-Jie Shen, Bin Kong, He Huang Source Type: research
Intracardiac Thrombus Following Rivaroxaban Treatment in a Patient with Atrial Fibrillation Associated with Rheumatic Heart Disease
We report a case of atrial fibrillation with rheumatic heart disease (RHD) who had intracardiac thrombus and cardiogenic cerebral embolism with rivaroxaban therapy. Intracardiac thrombus disappeared after switching from rivaroxaban to warfarin. Patients of RHD have the possibility of gradual progression of valvular disease even if they are old, so we need to distinguish nonvalvular atrial fibrillation from RHD before starting direct oral anticoagulants.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2019 Category: Neurology Authors: Hiroaki Ohara, Shiro Yamamoto, Keiko Nagano, Kazuo Hashikawa Tags: Case Report Source Type: research
Resumption of Direct Oral Anticoagulants in Patients with Acute Spontaneous Intracerebral Hemorrhage
We examined the timing of DOAC resumption and factors that influence decision-making in DOAC resumption. Methods: We retrospectively analyzed 43 patients with ICH who were treated with DOAC for nonvalvular atrial fibrillation before ICH onset. All patients were divided into 2 groups (resumption of DOAC and no resumption of DOAC) during hospitalization.
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2019 Category: Neurology Authors: Yuji Kato, Takeshi Hayashi, Kaima Suzuki, Hajime Maruyama, Yuichiro Kikkawa, Hiroki Kurita, Masaki Takao Source Type: research
