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Nine-Year Trend of Anticoagulation Use, Thromboembolic Events, and Major Bleeding in Patients With Non-Valvular Atrial Fibrillation　- Shinken Database Analysis.
CONCLUSIONS: The 9-year trend of stroke prevention indicated a steady increase of OAC prescription and a partial improvement of TE and MB. Even in the era of DOAC, TE prevention was insufficient in high-risk patients, and DOAC were associated with increased extracranial bleeding. PMID: 26794283 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 21, 2016 Category: Cardiology Authors: Suzuki S, Otsuka T, Sagara K, Semba H, Kano H, Matsuno S, Takai H, Kato Y, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Kunihara T, Yajima J, Sawada H, Aizawa T, Yamashita T Tags: Circ J Source Type: research

Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Predicts Postoperative Atrial Fibrillation in Patients Undergoing Mitral Valve Surgery for Mitral Valve Regurgitation.
CONCLUSIONS: PA-TDI duration was an independent predictor of POAF after MVS. Patients with PA-TDI duration >159.4 ms should be considered high risk and treated appropriately to improve outcome. PMID: 26538374 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 4, 2015 Category: Cardiology Authors: Takahashi S, Katayama K, Watanabe M, Kodama H, Taguchi T, Kurosaki T, Imai K, Sueda T Tags: Circ J Source Type: research

Greater Severity of Neurological Defects in Women Admitted With Atrial Fibrillation-Related Stroke.
CONCLUSIONS: Female sex was independently associated with the initial neurological severity among AF-related cardioembolic stroke patients. PMID: 26511462 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 29, 2015 Category: Cardiology Authors: Nezu T, Hosomi N, Kondo K, Aoki S, Matsumoto M, Kobayashi S, Japan Standard Stroke Registry Study Group Tags: Circ J Source Type: research

Effects of Regional Differences in Asia on Efficacy and Safety of Edoxaban Compared With Warfarin　- Insights From the ENGAGE AF-TIMI 48 Trial.
CONCLUSIONS: HDE had a greater relative efficacy and safety in EA compared with Japan that was only partially explained by differences in baseline characteristics and TTR. PMID: 26460886 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 9, 2015 Category: Cardiology Authors: Shimada YJ, Yamashita T, Koretsune Y, Kimura T, Abe K, Sasaki S, Mercuri M, Ruff CT, Giugliano RP Tags: Circ J Source Type: research

Use of Warfarin in Elderly Patients With Non-Valvular Atrial Fibrillation　- Subanalysis of the J-RHYTHM Registry.
CONCLUSIONS: Warfarin could have beneficial effects even in very old NVAF patients if INR is kept between 1.6 and 2.59. PMID: 26329097 [PubMed - as supplied by publisher]
Source: Circulation Journal - September 1, 2015 Category: Cardiology Authors: Kodani E, Atarashi H, Inoue H, Okumura K, Yamashita T, Origasa H, J-RHYTHM Registry Investigators Tags: Circ J Source Type: research

Predictors and Proarrhythmic Consequences of Inappropriate Implantable Cardioverter-Defibrillator Therapy.
CONCLUSIONS: Young age, paroxysmal atrial fibrillation, stroke, and no use of diuretics were independently associated with inappropriate ICD shocks. Proarrhythmic inappropriate ICD therapy was observed with an annual incidence of 0.18% by ATP. PMID: 26104029 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 24, 2015 Category: Cardiology Authors: Tenma T, Yokoshiki H, Mizukami K, Mitsuyama H, Watanabe M, Sasaki R, Maeno M, Matsui Y, Tsutsui H Tags: Circ J Source Type: research

Does Left Atrial Appendage Morphology Influence Left Atrial Appendage Flow Velocity?
CONCLUSIONS: The NCW-type LAA and higher BNP were associated with lower LAAFV. One reason for the frequent cardiogenic stroke in patients with the NCW-type LAA may be the lower LAAFV. PMID: 25959433 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 9, 2015 Category: Cardiology Authors: Kishima H, Mine T, Ashida K, Sugahara M, Kodani T, Masuyama T Tags: Circ J Source Type: research

Clinical Significance of Non-Vitamin K Antagonist Oral Anticoagulants in the Management of Atrial Fibrillation.
Abstract Atrial fibrillation (AF) is the most commonly observed rhythm disorder in clinical practice. It is associated with a high risk of thromboembolic stroke and increased cardiovascular mortality. Vitamin K antagonists (VKAs), the only oral anticoagulants used for thromboembolic prophylaxis in AF patients over the past 60 years, have been effective in reducing thromboembolic stroke, compared with placebo and aspirin, in this group of patients. However, VKAs have a very narrow therapeutic window, so regular monitoring of the therapeutic effect is obligatory for their use. The need for regular assessment of bloo...
Source: Circulation Journal - April 2, 2015 Category: Cardiology Authors: Santarpia G, Curcio A, Sibilio G, Indolfi C Tags: Circ J Source Type: research

Intracranial Hemorrhage Caused by Non-Vitamin K Antagonist Oral Anticoagulants (NOACs).
Conclusions:More than half the stroke center directors who responded to our questionnaire had not experienced cases of NOAC-associated ICH. Compared with warfarin, NOACs appear to present a lower risk of HE and death in patients with atrial fibrillation who develop CH. PMID: 25739470 [PubMed - as supplied by publisher]
Source: Circulation Journal - February 20, 2015 Category: Cardiology Authors: Saji N, Kimura K, Aoki J, Uemura J, Sakamoto Y Tags: Circ J Source Type: research

Low Body Weight Is Associated With the Incidence of Stroke in Atrial Fibrillation Patients.
Conclusions:Patients in the LBW group had high risk profiles and showed a higher incidence of stroke/SE, but the incidence of major bleeding was not particularly high. PMID: 25740669 [PubMed - as supplied by publisher]
Source: Circulation Journal - February 13, 2015 Category: Cardiology Authors: Hamatani Y, Ogawa H, Uozumi R, Iguchi M, Yamashita Y, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Abe M, Morita S, Akao M Tags: Circ J Source Type: research

Early Administration of Non-Vitamin K Antagonist Oral Anticoagulants for Acute Ischemic Stroke Patients With Atrial Fibrillation in Comparison With Warfarin Mostly Combined With Heparin.
Conclusions:This study suggests that NOACs are suitable for AIS patients with Af, perhaps even better than warfarin, given their simplicity. PMID: 25736910 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 23, 2015 Category: Cardiology Authors: Nomura E, Ohshita T, Imamura E, Wakabayashi S, Kajikawa H, Hosomi N, Matsumoto M Tags: Circ J Source Type: research

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants vs. Warfarin in Japanese Patients With Atrial Fibrillation.
Conclusions:NOAC are more efficacious than warfarin for the prevention of stroke and systemic embolism in Japanese patients with NVAF. The present findings offer clinicians a more comprehensive picture of NOAC as a therapeutic option to reduce the risk of stroke in Japanese NVAF patients. PMID: 25501801 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 11, 2014 Category: Cardiology Authors: Senoo K, Lau YC, Dzeshka M, Lane D, Okumura K, Lip GY Tags: Circ J Source Type: research

Incidence of Ischemic Stroke in Japanese Patients With Atrial Fibrillation Not Receiving Anticoagulation Therapy.
Conclusions:A low incidence rate of ischemic stroke was observed in Japanese NVAF patients except for those with CHADS2 score ≥2. In this pooled analysis, history of ischemic stroke or transient ischemic attack, advanced age, and hypertension were identified as independent risk factors for ischemic stroke. PMID: 25501800 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 11, 2014 Category: Cardiology Authors: Suzuki S, Yamashita T, Okumura K, Atarashi H, Akao M, Ogawa H, Inoue H Tags: Circ J Source Type: research

Bare-Metal vs. Drug-Eluting Stents in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.
Conclusions:In real-world patients with AF undergoing PCI, DES use was associated with outcomes comparable to those with BMS without excess bleeding complications. More ST was seen in BMS-treated patients. PMID: 25298168 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 9, 2014 Category: Cardiology Authors: Kiviniemi T, Puurunen M, Schlitt A, Rubboli A, Karjalainen P, Nammas W, Kirchhof P, Biancari F, Lip GY, Airaksinen KJ Tags: Circ J Source Type: research

Impact of Non-Vitamin K Antagonist Oral Anticoagulants on Intracranial Bleeding in Asian Patients With Non-Valvular Atrial Fibrillation.
Abstract The incidence of intracranial bleeding is known to be markedly higher in Japan and other East Asian countries than in countries outside of East Asia. Non-vitamin K antagonist oral anticoagulants (NOACs) have much lower risk of intracranial bleeding than warfarin, so we reviewed the effect of this class of drugs on intracranial bleeding in Asian patients with non-valvular atrial fibrillation (NVAF). Warfarin therapy in Asian or East Asian populations appears to be associated with lower efficacy, poorer safety and a much greater risk of intracranial bleeding when compared with non-Asian or non-East Asian gr...
Source: Circulation Journal - September 10, 2014 Category: Cardiology Authors: Yasaka M, Lip GY Tags: Circ J Source Type: research

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