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Edoxaban vs. Warfarin in East Asian Patients With Atrial Fibrillation　- An ENGAGE AF-TIMI 48 Subanalysis.
CONCLUSIONS: Once-daily edoxaban provided similar efficacy to warfarin while reducing major bleeding risk in the East Asian population. PMID: 26888149 [PubMed - as supplied by publisher]
Source: Circulation Journal - February 16, 2016 Category: Cardiology Authors: Yamashita T, Koretsune Y, Yang Y, Chen SA, Chung N, Shimada YJ, Kimura T, Miyazaki K, Abe K, Mercuri M, Ruff CT, Giugliano RP Tags: Circ J Source Type: research

Left Atrial Appendage Occlusion in Non-Valvular Atrial Fibrillation in a Korean Multi-Center Registry.
CONCLUSIONS: LAA occlusion was feasible in non-valvular AF patients with high risk of stroke and hemorrhage. The ACP and Watchman devices were similar in terms of procedural and clinical outcomes. PMID: 26984716 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 17, 2016 Category: Cardiology Authors: Kim JS, Lee H, Suh Y, Pak HN, Hong GR, Shim CY, Yu CW, Lee HJ, Kang WC, Shin ES, Choi RK, Kar S, Park JW, Lim DS, Jang Y Tags: Circ J Source Type: research

Sex-Related Differences in the Clinical Events of Patients With Atrial Fibrillation 　- The Fushimi AF Registry.
CONCLUSIONS: We demonstrated that female sex is not independently associated with an increased risk of thromboembolism, but is associated with a decreased risk of intracranial hemorrhage and all-cause death in Japanese AF patients enrolled in the Fushimi AF Registry. PMID: 28539562 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 25, 2017 Category: Cardiology Authors: Ogawa H, Hamatani Y, Doi K, Tezuka Y, An Y, Ishii M, Iguchi M, Masunaga N, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Abe M, Lip GY, Akao M, Fushimi AF Registry Investigators Tags: Circ J Source Type: research

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients 　- Meta-Analysis.
CONCLUSIONS: In East Asia, AF was significantly associated with SCI and no racial difference was seen between East Asian and non-Asian patients. The present findings offer clinicians new insights into the association between AF and SCI. PMID: 29279460 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 27, 2017 Category: Cardiology Authors: Senoo K, Kondo Y, Kobayashi Y, Lip GY Tags: Circ J Source Type: research

Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation 　- The Hokuriku-Plus AF Registry.
CONCLUSIONS: In a real-world cohort of Japanese NVAF patients, high BNP was significantly associated with TE and death. Plasma BNP might be a useful biomarker for these adverse clinical events. PMID: 29491320 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 1, 2018 Category: Cardiology Authors: Hayashi K, Tsuda T, Nomura A, Fujino N, Nohara A, Sakata K, Konno T, Nakanishi C, Tada H, Nagata Y, Teramoto R, Tanaka Y, Kawashiri MA, Yamagishi M, Hokuriku-Plus AF Registry Investigators Tags: Circ J Source Type: research

Clinical Correlates and Prognostic Value of Elevated Right Atrial Pressure in Patients With Hypertrophic Cardiomyopathy.
CONCLUSIONS: Elevated RAP in patients with HCM is associated with left-sided heart failure and is an independent predictor of all-cause mortality and new-onset AF. PMID: 29526913 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 9, 2018 Category: Cardiology Authors: McCullough SA, Fifer MA, Mohajer P, Lowry PA, Reen CO, Baggish AL, Vlahakes GJ, Shimada YJ Tags: Circ J Source Type: research

Sex Differences in Long-Term Clinical Outcomes in Patients With Atrial Fibrillation Undergoing Coronary Stent Implantation.
CONCLUSIONS: Among patients with concomitant AF and coronary stenting, there were no significant differences in the adjusted 3-year risks for all-cause death, myocardial infarction, and stroke between men and women. However, women as compared with men were associated with excess adjusted risk for major bleeding. PMID: 29593146 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 29, 2018 Category: Cardiology Authors: Matsumura-Nakano Y, Shiomi H, Morimoto T, Shizuta S, Yamaji K, Watanabe H, Yoshikawa Y, Taniguchi T, Kawaji T, Natsuaki M, Akasaka T, Hanaoka K, Kadota K, Kozuma K, Tanabe K, Nakagawa Y, Muramatsu T, Morino Y, Ando K, Kimura T Tags: Circ J Source Type: research

Comparison Between Long-Term Clinical Outcomes of Vitamin K Antagonist and Direct Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.
CONCLUSIONS: Compared with DOACs, VKA with poorly controlled INR and antiplatelet agents correlated with adverse outcomes of death, MI, stroke, and TLR in patients undergoing PCI. PMID: 29863094 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 1, 2018 Category: Cardiology Authors: Yoshida R, Morishima I, Takagi K, Morita Y, Tsuboi H, Murohara T Tags: Circ J Source Type: research

Current Status, Time Trends and Outcomes of Combination Therapy With Oral Anticoagulant and Antiplatelet Drug in Patients With Atrial Fibrillation 　- The Fushimi AF Registry.
CONCLUSIONS: In Japanese AF patients receiving OAC, the prevalence of combination therapy decreased, with the proportion of NOAC use increasing in 2011-2017. Many patients, however, received off-label NOAC under-dosing, especially in the combination therapy group. Patients with combination therapy had higher incidences of major bleeding as well as stroke/systemic embolism, compared with OAC monotherapy. PMID: 30381701 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 31, 2018 Category: Cardiology Authors: Masunaga N, Abe M, Ogawa H, Aono Y, Ikeda S, Doi K, An Y, Ishii M, Iguchi M, Esato M, Tsuji H, Wada H, Hasegawa K, Lip GYH, Akao M, Fushimi AF Registry Investigators Tags: Circ J Source Type: research

Extent of Late Gadolinium Enhancement Predicts Thromboembolic Events in Patients With Hypertrophic Cardiomyopathy.
CONCLUSIONS: LGE extent (>14.4%) is an independent predictor for thromboembolic complications in patients with HCM and might therefore be considered as an important risk marker. The risk for thromboembolic events is significantly elevated if accompanied by AF. PMID: 32238665 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 31, 2020 Category: Cardiology Authors: Hohneck A, Overhoff D, Doesch C, Sandberg R, Rudic B, Tueluemen E, Budjan J, Szabo K, Borggrefe M, Papavassiliu T Tags: Circ J Source Type: research

Optimal Management of Anticoagulation Therapy in Asian Patients With Atrial Fibrillation
Circ J. 2021 Jun 5. doi: 10.1253/circj.CJ-21-0399. Online ahead of print.ABSTRACTStroke prevention is the cornerstone of management of atrial fibrillation (AF), and non-vitamin K antagonist oral anticoagulants (NOACs) are commonly prescribed. Because routine monitoring of anticoagulant effects of NOACs is not necessary, appropriate dosing following the criteria of each NOACs defined in pivotal randomized trials is important. Real-world data demonstrate that underdosing NOACs is associated with a higher risk of ischemic stroke without a lower risk of major bleeding. Furthermore, renal function of AF patients should be asses...
Source: Circulation Journal - June 7, 2021 Category: Cardiology Authors: Wen-Han Cheng Yi-Hsin Chan Jo-Nan Liao Ling Kuo Shih-Ann Chen Tze-Fan Chao Source Type: research

Additional Effects of Antiplatelet Therapy on Anticoagulant Agents in Patients With Bioprosthetic Valves and Atrial Fibrillation
CONCLUSIONS: Additional SAPT on anticoagulant therapy in patients with bioprosthetic valves and AF was associated with a reduction in stroke/systemic embolic events, although the cumulative incidence of bleeding was similar, regardless of additional SAPT. These findings suggest that additional SAPT on anticoagulant therapy may be safe and effective in real-world clinical settings.PMID:34853280 | DOI:10.1253/circj.CJ-21-0716
Source: Circulation Journal - December 2, 2021 Category: Cardiology Authors: Masashi Amano Makoto Miyake Takeshi Kitai Yuki Obayashi Misa Takegami Kunihiro Nishimura Yutaka Furukawa Chisato Izumi Source Type: research

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