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Source: Circulation
Condition: Atrial Fibrillation

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Total 235 results found since Jan 2013.

Pharmacology and Clinical Development of Factor XI Inhibitors
This article reviews the rationale, pharmacology, results of medium or small phase 2 studies, and future perspectives of drugs inhibiting FXI.PMID:36913497 | DOI:10.1161/CIRCULATIONAHA.122.062353
Source: Circulation - March 13, 2023 Category: Cardiology Authors: Antonio Greco Claudio Laudani Marco Spagnolo Federica Agnello Denise Cristiana Faro Simone Finocchiaro Marco Legnazzi Maria Sara Mauro Placido Maria Mazzone Giovanni Occhipinti Carla Rochira Lorenzo Scalia Davide Capodanno Source Type: research

New Oral Anticoagulants in Atrial Fibrillation Forever?
Abstract Atrial fibrillation is the most common chronic cardiac arrhythmia in clinical cardiology. It affects about 1% of the population, and of individuals over the age of 80 about 10% have this rhythm disturbance. Due to the loss of the atrial contribution to ventricular filling, left ventricular function is diminished resulting in a propensity to heart failure, fatigue and disability. Furthermore, the sensation of palpations can be very disturbing for younger patients and may hamper them in their physical and professional activities. Finally, the diminished blood flow through the heart, especially the left atri...
Source: Circulation - June 14, 2013 Category: Cardiology Authors: Verheugt FW Tags: Circulation Source Type: research

Oxidative Stress and Atrial Fibrillation: Finding a Missing Piece to the Puzzle.
Abstract Atrial fibrillation (AF), one of the most prevalent cardiac arrhythmias, afflicts more than 3 million people in the United States.(1) As the risk of developing AF increases with age, the prevalence of AF is projected to be 7.6 million in 2050,(1) when one in five Americans will be over the age of 65.(2) AF not only causes debilitating symptoms and functional impairments owing to worsened hemodynamics and embolic stroke, it also increases the risk of mortality up to 1.5-1.9 fold.(3) Despite the significant morbidity and mortality burden incurred with AF, there are limited therapeutic options that may impro...
Source: Circulation - September 12, 2013 Category: Cardiology Authors: Yang KC, Dudley SC Tags: Circulation Source Type: research

Inhospital Complications Associated with Catheter Ablation of Atrial Fibrillation in the United States between 2000-2010: Analysis of 93,801 Procedures.
CONCLUSIONS: The overall complication rate was 6.29% in patients undergoing AF ablation. There was a significant association between operator and hospital volume on adverse outcomes. This suggests a need for future research into identifying the safety measures in AF ablations and instituting appropriate interventions to improve overall AF ablation outcomes. PMID: 24061087 [PubMed - as supplied by publisher]
Source: Circulation - September 23, 2013 Category: Cardiology Authors: Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, Grover P, Singh V, Vallurupalli S, Savani GT, Badheka A, Tuliani T, Dabhadkar K, Dibu G, Reddy YM, Sewani A, Kowalski M, Mitrani R, Paydak H, Viles-Gonzalez JF Tags: Circulation Source Type: research

Platelet Activation after Radiofrequency Ablation in Atrial Fibrillation: Is There Any Clinical Implication?
Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia in the general population and in patients undergoing cardiac surgery(1). AF is a self-perpetuating arrhythmia which is facilitated by structural and functional changes elicited by atrial high rate activity. Shortening of atrial effective refractory period is the earliest functional change that characterizes atrial remodeling(2). As prevalence of AF increases with advancing age, its social impact is becoming very relevant because of the associated high risk of cardiovascular events and increased morbidity and mortality. AF is complicated by str...
Source: Circulation - November 25, 2013 Category: Cardiology Authors: Violi F, Pignatelli P Tags: Circulation Source Type: research

Predictors of Long-Term Outcomes in Patients with Significant Myxomatous Mitral Regurgitation Undergoing Exercise Echocardiography.
CONCLUSIONS: In patients with ≥III+ myxomatous MR undergoing ExEc, lower %age-gender predicted METS, lower HRR, atrial fibrillation, lower LV ejection fraction and high resting RVSP predicted worse outcomes. PMID: 24396041 [PubMed - as supplied by publisher]
Source: Circulation - January 6, 2014 Category: Cardiology Authors: Naji P, Griffin BP, Asfahan F, Barr TS, Rodriguez LL, Grimm R, Agarwal S, Stewart WJ, Mihaljevic T, Gillinov AM, Desai MY Tags: Circulation Source Type: research

Preventing Cardiovascular Complications of Acute Infection: A Missed Opportunity?
Abstract "...This is an experimental verification of this medical concept, relatively new, suggesting that infections merit an important place in the etiology of human atheromatous arteritis..." -Gilbert A and Lion G, Comptes Rendus Hebdomadairesdes Séances et Mémoires de la Société de Biologie. Published 1889 The connections between infection and cardiovascular disease have been postulated for at least 125 years, when Gilbert and Lion observed that acute infection with the typhoid bacillus resulted in atherosclerotic changes to the rabbit aorta. In the last few decades, much work has investigated the role for...
Source: Circulation - February 12, 2014 Category: Cardiology Authors: Walkey AJ Tags: Circulation Source Type: research

Permanent Leadless Cardiac Pacing: Results of the LEADLESS Trial.
CONCLUSIONS: In a prospective non-randomized study, a completely self-contained single-chamber leadless cardiac pacemaker has shown to be safe and feasible. The absence of a transvenous lead and subcutaneous pulse generator could represent a paradigm shift in cardiac pacing. CLINICAL TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov. Identifier: NCT01700244. PMID: 24664277 [PubMed - as supplied by publisher]
Source: Circulation - March 24, 2014 Category: Cardiology Authors: Reddy VY, Knops RE, Sperzel J, Miller MA, Petru J, Simon J, Sediva L, de Groot JR, Tjong FV, Jacobson P, Ostroff A, Dukkipati SR, Koruth JS, Wilde AA, Kautzner J, Neuzil P Tags: Circulation Source Type: research

Extra-Virgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation: The PREDIMED Trial.
CONCLUSIONS: In the absence of proven interventions for the primary prevention of atrial fibrillation, this post-hoc analysis of the PREDIMED trial suggests that extra-virgin olive oil in the context of a Mediterranean dietary pattern may reduce the risk of atrial fibrillation. CLINICAL TRIAL REGISTRATION INFORMATION: controlled-trials.com. Identifier: ISRCTN35739639. PMID: 24787471 [PubMed - as supplied by publisher]
Source: Circulation - April 30, 2014 Category: Cardiology Authors: Martínez-González MA, Toledo E, Arós F, Fiol M, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fernández-Crehuet J, Lapetra J, Muñoz MA, Fitó M, Serra-Majem L, Pintó X, Lamuela-Raventós RM, Sorlí JV, Babio N, Buil-Cosiales P, Ruiz-Gutierrez V, Est Tags: Circulation Source Type: research

Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation.
CONCLUSIONS: -We have identified five novel loci for AF. Our results further expand the diversity of genetic pathways implicated in AF and provide novel molecular targets for future biological and pharmacological investigation. PMID: 25124494 [PubMed - as supplied by publisher]
Source: Circulation - August 14, 2014 Category: Cardiology Authors: Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL Tags: Circulation Source Type: research

Age-Specific Incidence, Outcome, Cost and Projected Future Burden of Atrial Fibrillation-Related Embolic Vascular Events: A Population-Based Study.
CONCLUSIONS: -Numbers of AF-related incident ischaemic strokes at age ≥80 years have trebled over the last 25 years, despite the introduction of anticoagulants, and are projected to treble again by 2050, along with the numbers of systemic emboli. Improved prevention in older people with AF should be a major public health priority. PMID: 25208551 [PubMed - as supplied by publisher]
Source: Circulation - September 10, 2014 Category: Cardiology Authors: Yiin GS, Howard DP, Paul NL, Li L, Luengo-Fernandez R, Bull LM, Welch SJ, Gutnikov SA, Mehta Z, Rothwell PM, on behalf of the Oxford Vascular Study Tags: Circulation Source Type: research

Edoxaban Effects on Bleeding Following Punch Biopsy and Reversal by a 4-Factor Prothrombin Complex Concentrate.
CONCLUSIONS: -The 4F-PCC dose-dependently reversed the effects of edoxaban (60 mg), with complete reversal of bleeding duration and endogenous thrombin potential and partial reversal of prothrombin time following 50 IU/kg. Edoxaban alone and in combination with 4F-PCC was safe and well tolerated in these healthy subjects. A dose of 50 IU/kg 4F-PCC may be suitable for reversing edoxaban anticoagulation. Clinical Trial Registration-URL: http://clinicaltrials.gov. Unique identifier: NCT02047565. PMID: 25403645 [PubMed - as supplied by publisher]
Source: Circulation - November 17, 2014 Category: Cardiology Authors: Zahir H, Brown KS, Vandell A, Desai M, Maa JF, Dishy V, Lomeli B, Feussner A, Feng W, He L, Grosso MA, Lanz HJ, Antman EM Tags: Circulation Source Type: research

A Bridge Too Far? Findings of Bridging Anticoagulation Use and Outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).
Abstract In the current issue of Circulation, Steinberg et al. describe use and outcomes associated with bridging anticoagulation (AC) in patients with atrial fibrillation (AF) in the contemporary Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF)(1). Chronic oral anticoagulation (OAC) significantly reduces the risk of stroke or thromboembolism in patients with atrial fibrillation (AF). Despite the growing population burden of AF(2), increasing use of OAC, and frequent need for cardiac and non-cardiac procedures in this population, remarkably little contemporary data exist to help guide the clinician...
Source: Circulation - December 12, 2014 Category: Cardiology Authors: Shaikh AY, McManus DD Tags: Circulation Source Type: research

Use and Outcomes Associated with Bridging During Anticoagulation Interruptions in Patients with Atrial Fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).
CONCLUSIONS: -Bridging anticoagulation is used in one-quarter of anticoagulation interruptions and is associated with higher risk for bleeding and adverse events. These data do not support the use of routine bridging and additional data are needed to identify best practices around anticoagulation interruptions. Clinical Trial Registration Information-clinicaltrials.gov. Identifier: NCT01165710. PMID: 25499873 [PubMed - as supplied by publisher]
Source: Circulation - December 12, 2014 Category: Cardiology Authors: Steinberg BA, Peterson ED, Kim S, Thomas L, Gersh BJ, Fonarow GC, Kowey PR, Mahaffey KW, Sherwood MW, Chang P, Piccini JP, Ansell J, on behalf of the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators and Patie Tags: Circulation Source Type: research