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Efficacy and safety of direct oral anticoagulants vs vitamin K antagonists in patients with atrial fibrillation and end-stage renal disease on hemodialysis: A systematic review and meta-analysis
CONCLUSIONS: Among AF patients with ESRD on chronic hemodialysis, the risk of ischemic stroke, ischemic stroke or systemic embolism, minor bleeding, major bleeding, and all-cause mortality is similar in patients treated with DOACs compared to VKAs. Given that the meta-analysis of RCTs on gastrointestinal bleeding did not confirm the results of the meta-analysis of the observational studies, it cannot be concluded that gastrointestinal bleeding is lower among DOAC-treated patients.PROTOCOL REGISTRATION: PROSPERO CRD42023391966.PMID:37648582 | DOI:10.1016/j.ejim.2023.08.020
Source: European Journal of Internal Medicine - August 30, 2023 Category: Internal Medicine Authors: Ioannis Kyriakoulis Anastasia Adamou Iliana Stamatiou David Dimitris Chlorogiannis Ioannis Kardoutsos Despoina Koukousaki George Ntaios Source Type: research

A new strategy for anticoagulation: The factor XI inhibitors
Eur J Intern Med. 2023 Aug 4:S0953-6205(23)00284-4. doi: 10.1016/j.ejim.2023.08.001. Online ahead of print.ABSTRACTDirect oral anticoagulants (DOACs) are currently the first-choice therapy for the prevention of cardioembolic events in patients with atrial fibrillation and for the treatment of venous thromboembolism (VTE) due to their more favorable efficacy to safety profile in comparison to vitamin K antagonists (VKA). DOACs did not show a clinical benefit when used for in stroke prevention in patients with mechanic or rheumatic valves or in those who underwent transcatheter aortic valve implantation (TAVI), in the treatm...
Source: European Journal of Internal Medicine - August 6, 2023 Category: Internal Medicine Authors: Maria Cristina Vedovati Cecilia Becattini Giancarlo Agnelli Source Type: research

The Influence of baseline glycemic status on the effects of intensive blood pressure lowering: Results from the STEP randomized trial
CONCLUSION: The effects of intensive SBP lowering on cardiovascular outcomes were consistent among participants with normoglycemia, prediabetes, and diabetes.PMID:37142449 | DOI:10.1016/j.ejim.2023.04.019
Source: European Journal of Internal Medicine - May 4, 2023 Category: Internal Medicine Authors: Ruixue Yang Yixuan Wang Anli Tong Jing Yu Dechao Zhao Jun Cai Source Type: research

Prognostic implications of the 4S-AF scheme to characterize new-onset atrial fibrillation after myocardial infarction
CONCLUSIONS: Characterization of NOAF using the 4S-AF scheme aids in the risk stratification of AMI patients with NOAF.PMID:37037721 | DOI:10.1016/j.ejim.2023.04.003
Source: European Journal of Internal Medicine - April 10, 2023 Category: Internal Medicine Authors: Jiachen Luo Zhiqiang Li Xiaoming Qin Xingxu Zhang Xiangdong Liu Wenming Zhang Wei Xu Yiwei Zhang Yuan Fang Baoxin Liu Yidong Wei NOAFCAMI-SH Registry Investigators Source Type: research

Delaying clinical events among patients with non-valvular atrial fibrillation treated with oral anticoagulants: Insights from the ARISTOPHANES study
CONCLUSIONS: Over 12 months after initiation, apixaban and dabigatran conferred progressive increases in event free time for stroke/SE and MB vs warfarin, whereas rivaroxaban conferred an increase in stroke/SE-free time but a loss in MB-free time vs warfarin.PMID:36456387 | DOI:10.1016/j.ejim.2022.10.021
Source: European Journal of Internal Medicine - December 1, 2022 Category: Internal Medicine Authors: Steven Deitelzweig Allison Keshishian Amiee Kang Aaron Jenkins Nipun Atreja Patricia Schuler Jenny Jiang Huseyin Yuce Xiaoxi Sun Gregory Y H Lip Source Type: research

Mobile health-technology integrated care in atrial fibrillation patients with heart failure: A report from the mAFA-II randomized clinical trial
CONCLUSION: A mHealth-technology implemented ABC pathway provides consistent effects on the risks of primary outcome, rehospitalisation and bleeding, in AF patients both with and without HF. However, AF-HF patients may need tailored approaches to improve their overall prognosis, specifically to reduce the risk of recurrent AF, HF and acute coronary syndrome.PMID:36347740 | DOI:10.1016/j.ejim.2022.11.002
Source: European Journal of Internal Medicine - November 8, 2022 Category: Internal Medicine Authors: Yutao Guo Giulio Francesco Romiti Bernadette Corica Marco Proietti Niccol ò Bonini Hui Zhang Gregory Yh Lip mAF-App II trial investigators Source Type: research

Epidemiology of subclinical atrial fibrillation in patients with cardiac implantable electronic devices: A systematic review and meta-regression
CONCLUSIONS: In this systematic review and meta-regression analysis, SCAF was frequent among CIED recipients and was non-linearly associated with age and follow-up time. Older age, higher thromboembolic risk, and several cardiovascular comorbidities were associated with presence of SCAF.PMID:35817660 | DOI:10.1016/j.ejim.2022.06.023
Source: European Journal of Internal Medicine - July 11, 2022 Category: Internal Medicine Authors: Marco Proietti Giulio Francesco Romiti Marco Vitolo Marco Borgi Arianna Di Rocco Alessio Farcomeni Kazuo Miyazawa Jeff S Healey Deirdre A Lane Giuseppe Boriani Stefania Basili Gregory Y H Lip Source Type: research

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