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Source: The American Journal of Cardiology
Condition: Atrial Fibrillation
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Total 336 results found since Jan 2013.
Thromboembolism In The Absence Of Atrial Fibrillation
Atrial fibrillation (AF) is associated with thrombus formation in the left atrial appendage (LAA) and systemic embolic events including ischemic stroke. Cardiogenic thromboembolism can also occur in the absence of clinical AF as a result of various pathological conditions affecting the endocardium. The inconsistent temporal relation between AF and ischemic events has stimulated exploration for factors other than clinical AF that contribute to thromboembolism. These include sub-clinical AF, a thrombogenic atrial cardiomyopathy, LAA dysfunction and embolism from other sources.
Source: The American Journal of Cardiology - April 23, 2019 Category: Cardiology Authors: Jeffrey Smietana, Anna Plitt, Jonathan L. Halperin Source Type: research
Changes in Management Following Detection of Previously Unknown Atrial Fibrillation by an Insertable Cardiac Monitor (From the REVEAL AF Study)
The REVEAL AF study demonstrated a high incidence of previously undetected atrial fibrillation (AF) using insertable cardiac monitors (ICMs) in patients with risk factors for AF and stroke. This analysis evaluated whether ICM monitoring led to changes in clinical management following AF detection. Patients with CHADS2 scores ≥3 (or =2 with ≥1 additional AF risk factor) but no history of AF received an ICM and were followed 18-30 months. Physicians recorded changes in clinical management in response to AF detection at scheduled (every 6 months) and unscheduled follow-up visits.
Source: The American Journal of Cardiology - June 23, 2019 Category: Cardiology Authors: Atul Verma, Rolf Wachter, Peter R. Kowey, Jonathan L. Halperin, Bernard J. Gersh, Mitchell S.V. Elkind, Rachelle E. Kaplon, Paul D. Ziegler, Lou Sherfesee, James A. Reiffel Source Type: research
Meta-Analysis Evaluating Outcomes of Surgical Left Atrial Appendage Occlusion During Cardiac Surgery
Surgical left atrial appendage occlusion (S-LAAO) has become a common procedure performed in patients undergoing cardiac surgery; however, evidence to support this procedure remains inconclusive. This meta-analysis aims to assess the efficacy of S-LAAO in terms of ischemic stroke, postoperative atrial fibrillation (AF), and all-cause mortality. A thorough literature review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We identified ten relevant studies for our meta-analysis.
Source: The American Journal of Cardiology - July 31, 2019 Category: Cardiology Authors: Abdisamad M Ibrahim, Nitin Tandan, Cameron Koester, Mohammad Al-Akchar, Bishal Bhandari, Albert Botchway, Jumana Abdelkarim, Ruby Maini, Mohamed Labedi Source Type: research
The Interaction Among Atrial Thromboembolism, Atrial Fibrillation, and Atrial Cardiomyopathy
I read with interest the timely paper titled “Thromboembolism in the Absence of Atrial Fibrillation” by Smietana et al1 that discusses several highly important but underappreciated contributors to ischemic stroke in patients with and without atrial fibrillation (AF). Several are worthy of further emphasis and/or expansion for your readers, both investigators and clinicians. First is the recognition of the concept of atrial cardiomyopathy.2 Atrial cardiomyopathy may be a cause and/or consequence of AF; can vary with the etiology, duration, number, and severity of associated comorbidities as well as the amount of AF pres...
Source: The American Journal of Cardiology - August 1, 2019 Category: Cardiology Authors: James A. Reiffel Source Type: research
Effectiveness of Only Aspirin or Clopidogrel Following Percutaneous Left Atrial Appendage Closure
Percutaneous left atrial appendage closure (LAAC) offers a feasible option for stroke prevention in patients with atrial fibrillation (AF), but the optimal antithrombotic treatment strategy for patients with strict contraindications to oral anticoagulation (OAC) remains uncertain. We sought to evaluate short- and long-term outcome after percutaneous LAAC in these very patients discharged on single antiplatelet therapy (SAPT) alone. All consenting AF patients who underwent LAAC from February 2009 to August 2018 in Turku University Hospital, Finland, were enrolled into a prospectively maintained registry.
Source: The American Journal of Cardiology - September 25, 2019 Category: Cardiology Authors: Jussi-Pekka Pouru, Samuli Jaakkola, Juha Lund, Fausto Biancari, Antti Saraste, K. E. Juhani Airaksinen Source Type: research
Safety and Efficacy of Direct Oral Anticoagulants Versus Warfarin in Patients with Chronic Kidney Disease and Atrial Fibrillation
This study evaluated and compared the safety outcomes of DOACs versus warfarin in patients with non-valvular AF and concomitant CKD. Patients in our health system with AF prescribed oral anticoagulants during 2010 to 2017 were identified. All-cause mortality, bleeding, and hemorrhagic and ischemic stroke were evaluated based on degree of renal impairment and method of anticoagulation.
Source: The American Journal of Cardiology - October 30, 2019 Category: Cardiology Authors: Amber Makani, Samir Saba, Sandeep K. Jain, Aditya Bhonsale, Michael S. Sharbaugh, Floyd Thoma, Yisi Wang, Oscar C. Marroquin, Joon S. Lee, N.A. Mark Estes, Suresh R. Mulukutla Source Type: research
Detecting Atrial Fibrillation in Patients with an Embolic Stroke of Undetermined Source (From the DAF-ESUS registry)
Atrial fibrillation (AF) causes a substantial proportion of embolic strokes of undetermided source (ESUS). Effective detection of subclinical AF (SCAF) has important therapeutic implications. We conducted a prospective study to determine the prevalence of SCAF in patients with ESUS through of a 21-day Holter monitoring. In an early-monitoring group, Holter was initiated immediately after hospital discharge. The results were compared with a previous cohort of patients in whom the Holter was initiated at least one week after hospital discharge (late-monitoring group).
Source: The American Journal of Cardiology - November 5, 2019 Category: Cardiology Authors: Jos é Manuel Rubio Campal, M Araceli García Torres, Pepa Sánchez Borque, Inmaculada Navas Vinagre, Ivana Zamarbide Capdepón, Ángel Miracle Blanco, Loreto Bravo Calero, Rafael Sáez Pinel, José Tuñón Fernández, José María Serratosa Fernández Source Type: research
Comparison of Long-Term Risk Adverse Outcomes In Patients with Atrial Fibrillation Having Ablation vs Antiarrhythmic Medications
The impact of atrial fibrillation (AF) catheter ablation vs. chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients undergoing AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history of diab...
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: James V. Freeman, Grace H. Tabada, Kristi Reynolds, Sue Hee Sung, Daniel E. Singer, Paul J. Wang, Taylor I. Liu, Nigel Gupta, Mark A. Hlatky, Alan S. Go Source Type: research
Comparison of Long-Term Adverse Outcomes in Patients With Atrial Fibrillation Having Ablation Versus Antiarrhythmic Medications
The impact of atrial fibrillation (AF) catheter ablation versus chronic antiarrhythmic therapy alone on clinical outcomes such as death and stroke remains unclear. We compared adverse outcomes for AF ablation versus chronic antiarrhythmic therapy in 1,070 adults with AF treated between 2010 and 2014 in the Kaiser Permanente Northern California and Southern California healthcare delivery systems. Patients who underwent AF catheter ablation were matched to patients treated with only antiarrhythmic medications, based on age, gender, history of heart failure, history of coronary heart disease, history of hypertension, history ...
Source: The American Journal of Cardiology - November 18, 2019 Category: Cardiology Authors: James V. Freeman, Grace H. Tabada, Kristi Reynolds, Sue Hee Sung, Daniel E. Singer, Paul J. Wang, Taylor I. Liu, Nigel Gupta, Mark A. Hlatky, Alan S. Go Source Type: research
Pattern and Impact of Off-label Underdosing of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation Who Are Indicated for Standard Dosing
With safety concerns about increasing bleeding, off-label underdosing of non-vitamin K antagonist anticoagulants (NOACs) is common in East Asian patients with atrial fibrillation (AF). We tried to investigate the pattern of NOAC underdosing and associated clinical outcomes in patients with AF who are indicated for standard dosing. Using the Korean National Health Insurance Service database, we evaluated 16568 patients with a new prescription of NOAC who are indicated for standard NOAC dosing and compared 4536 patients with warfarin with respect to thromboembolic events (ischemic stroke or systemic embolization), all-cause ...
Source: The American Journal of Cardiology - February 6, 2020 Category: Cardiology Authors: Min Soo Cho, Ji Eun Yun, Ji Jeong Park, Yun Jung Kim, Jessie Lee, Hyungmin Kim, Duk-Woo Park, Gi-Byoung Nam Source Type: research
Usefulness of Long-term Anticoagulation after Catheter Ablation of Atrial Fibrillation
Although atrial fibrillation (AF) is strongly associated with stroke, previous studies have shown suboptimal use of anticoagulation (AC). In particular, there is a lack of data on the long-term use of AC after AF catheter ablation. We followed up patients 1-5 years out from catheter ablation at the Johns Hopkins Hospital (JHH) to assess their long-term use of AC. We sent a survey to patients from the JHH AF database who underwent an AF catheter ablation between 01/01/2014 and 03/31/2018. Patients were asked whether they were still on AC, if they thought the ablation was successful in controlling AF symptoms and whether the...
Source: The American Journal of Cardiology - May 11, 2020 Category: Cardiology Authors: Rafael Arias, George Leef, Usama Daimee, Bhradeev Sivasambu, Tauseef Akhtar, Joseph E. Marine, Ronald Berger, Hugh Calkins, David Spragg Source Type: research
Objectively Measured Physical Activity and the Risk of Atrial Fibrillation (From the REGARDS Study)
The association between objectively measured physical activity and atrial fibrillation (AF) has not been examined. Therefore, we examined the association between moderate and vigorous physical activity (MVPA) with incident AF in 5,147 participants who completed accelerometer assessment for 4 to 7 consecutive days in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. MVPA was defined as>1065 counts/minute, and daily mean time spent in MVPA was computed. Incident AF was identified during follow-up by a study-scheduled electrocardiogram and also from self-reported medical history of a physician diagnosis.
Source: The American Journal of Cardiology - May 13, 2020 Category: Cardiology Authors: Wesley T. O'Neal, Aleena Bennett, Matthew J. Singleton, Suzanne E. Judd, George Howard, Virginia J. Howard, Steven P. Hooker, Elsayed Z. Soliman Source Type: research
Baseline CHADS2 Score and Risk of Cardiovascular Events in the Population without Atrial Fibrillation
The association between CHADS2 score and stroke has been confirmed in patients with atrial fibrillation. But the majority of cardiovascular events occurred primarily in population without atrial fibrillation. Therefore, we performed this cohort study to evaluate the association between baseline CHADS2 score and cardiovascular events in the population without atrial fibrillation. A total of 99,755 Chinese adults with complete baseline data were followed for up to 10 years. The primary outcomes were cardiovascular event (a composite endpoint of myocardial infarction, cerebral infarction and cerebral hemorrhage) and all-cause death.
Source: The American Journal of Cardiology - June 2, 2020 Category: Cardiology Authors: Chunpeng Ji, Shouling Wu, Jihong Shi, Zhe Huang, ShuohuaChen, Guodong Wang, Wei Cui Source Type: research
Effects of Atrial Fibrillation and Chronic Kidney Disease on Major Adverse Cardiovascular Events
Atrial fibrillation (AF) is strongly linked to chronic kidney disease (CKD) and both of these conditions contribute to poor cardiovascular outcomes. We evaluated the impact of renal failure on major adverse cardiovascular events (MACE) in AF, and predictive value of the 2MACE score in this post-hoc analysis of the AMADEUS trial. The primary endpoint was MACE (composite of myocardial infarction, cardiac revascularisation and cardiovascular mortality). Secondary endpoints included the composite of stroke, major bleeding and non-cardiovascular mortality, and each of the specific outcomes separately.
Source: The American Journal of Cardiology - July 10, 2020 Category: Cardiology Authors: Wern Yew Ding, Gregory Y.H. Lip, Daniele Pastori, Alena Shantsila Source Type: research
Prognostic Implications of Significant Isolated Tricuspid Regurgitation in Patients With Atrial Fibrillation Without Left-Sided Heart Disease or Pulmonary Hypertension
The prognostic impact of isolated tricuspid regurgitation (TR) in patients with atrial fibrillation (AF) has not been investigated. The purpose of this study was to investigate the prognostic implications of significant isolated TR in AF patients without left-sided heart disease, pulmonary hypertension or primary structural abnormalities of the tricuspid valve.A total of 63 AF patients with moderate and severe TR were matched for age and gender to 116 AF patients without significant TR. Patients were followed for the occurrhttps://doi.org/10.13039/100006520ence of all-cause mortality, hospitalization for heart failure and stroke.
Source: The American Journal of Cardiology - August 27, 2020 Category: Cardiology Authors: Marlieke F Dietz, Laurien Goedemans, N Mai Vo, Edgard A Prihadi, Pieter van der Bijl, Bernard J Gersh, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax Source Type: research
