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Insufficient Warfarin Therapy Is Associated With Higher Severity of Stroke Than No Anticoagulation in Patients With Atrial Fibrillation and Acute Anterior-Circulation Stroke.
CONCLUSIONS: Insufficient VKA therapy on admission was associated with higher severity of stroke and higher prevalence of proximal artery occlusion in patients with AF and acute anterior-circulation stroke compared with no anticoagulant medication. PMID: 29269702 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 21, 2017 Category: Cardiology Authors: Sakamoto Y, Okubo S, Nito C, Suda S, Matsumoto N, Nishiyama Y, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Mishina M, Kimura K Tags: Circ J Source Type: research

Two-Year Outcomes of Anticoagulation for Acute Ischemic Stroke With Nonvalvular Atrial Fibrillation 　- SAMURAI-NVAF Study.
CONCLUSIONS: Stroke/TIA patients receiving DOACs for secondary prevention were younger and had lower stroke severity and risk indices than those receiving warfarin. Estimated cumulative incidences of stroke and systemic embolism within 2 years were similar between warfarin and DOACs users, but those of death and intracranial hemorrhage were significantly lower among DOAC users. PMID: 29863095 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 1, 2018 Category: Cardiology Authors: Yoshimura S, Koga M, Sato S, Todo K, Yamagami H, Kumamoto M, Itabashi R, Terasaki T, Kimura K, Yagita Y, Shiokawa Y, Kamiyama K, Okuda S, Okada Y, Takizawa S, Hasegawa Y, Kameda T, Shibuya S, Nagakane Y, Ito Y, Matsuoka H, Takamatsu K, Nishiyama K, Fujita Tags: Circ J Source Type: research

Timing of Treatment Initiation With Oral Anticoagulants for Acute Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation.
CONCLUSIONS: Our study revealed that neurologists began OACs earlier in patients with mild acute cerebral infarction. Even in patients with severe stroke, OACs were started earlier than expected. PMID: 27980235 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 12, 2016 Category: Cardiology Authors: Deguchi I, Tanahashi N, Takao M Tags: Circ J Source Type: research

Anticoagulants, Reperfusion Therapy, and Outcomes in Ischemic Stroke Patients With Non-Valvular Atrial Fibrillation 　- A Single-Center, 6-Year Experience of 546 Consecutive Patients.
CONCLUSIONS: Inappropriate anticoagulant use for stroke patients with NVAF did not decrease over time. An increase in reperfusion therapy was a strong factor in improved functional outcomes and mortality. PMID: 30158346 [PubMed - as supplied by publisher]
Source: Circulation Journal - August 30, 2018 Category: Cardiology Authors: Suda S, Sakamoto Y, Okubo S, Aoki J, Shimoyama T, Kanamaru T, Suzuki K, Kutsuna A, Matsumoto N, Nito C, Nishiyama Y, Mishina M, Kimura K Tags: Circ J Source Type: research

Relationship Between Infarct Volume and Prothrombin Time-International Normalized Ratio in Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation.
CONCLUSIONS: Warfarin control at PT-INR of 1.60-1.99 is not effective for reducing the severity of ischemic stroke in NVAF patients. PMID: 28154247 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 30, 2017 Category: Cardiology Authors: Matsumoto M, Sakaguchi M, Okazaki S, Hashikawa K, Takahashi T, Matsumoto M, Ohtsuki T, Shimazu T, Yoshimine T, Mochizuki H, Kitagawa K Tags: Circ J Source Type: research

Early Administration of Non-Vitamin K Antagonist Oral Anticoagulants for Acute Ischemic Stroke Patients With Atrial Fibrillation in Comparison With Warfarin Mostly Combined With Heparin.
Conclusions:This study suggests that NOACs are suitable for AIS patients with Af, perhaps even better than warfarin, given their simplicity. PMID: 25736910 [PubMed - as supplied by publisher]
Source: Circulation Journal - January 23, 2015 Category: Cardiology Authors: Nomura E, Ohshita T, Imamura E, Wakabayashi S, Kajikawa H, Hosomi N, Matsumoto M Tags: Circ J Source Type: research

Seasonal Variations in the Incidence of Ischemic Stroke, Extracranial and Intracranial Hemorrhage in Atrial Fibrillation Patients.
CONCLUSIONS: Significant seasonal variations were observed for IS, ECH, and ICH events in AF patients, and were consistently the highest in winter. A small peak of ECH was observed in summer, which seemed, in part, to be related to increased DOAC use. PMID: 32863288 [PubMed - as supplied by publisher]
Source: Circulation Journal - August 27, 2020 Category: Cardiology Authors: Oida M, Suzuki S, Arita T, Yagi N, Otsuka T, Kishi M, Semba H, Kano H, Matsuno S, Kato Y, Uejima T, Oikawa Y, Hoshino S, Matsuhama M, Inoue T, Yajima J, Yamashita T Tags: Circ J Source Type: research

Effectiveness and Safety of Rivaroxaban by General Practitioners 　- A Multicenter, Prospective Study in Japanese Patients With Non-Valvular Atrial Fibrillation (GENERAL)
CONCLUSIONS: The low incidence of adverse events, including stroke/SE and bleeding, in patients prescribed rivaroxaban by general practitioners supports its use as a safe and efficacious treatment in the standard clinical care of high-risk patient populations.PMID:33814525 | DOI:10.1253/circj.CJ-20-1244
Source: Circulation Journal - April 5, 2021 Category: Cardiology Authors: Kengo Kusano Nobuyoshi Sugishita Masaharu Akao Hikari Tsuji Kunihiko Matsui Shinya Hiramitsu Yutaka Hatori Hironori Odakura Hiroyuki Kamada Koji Miyamoto Hisao Ogawa Source Type: research

Inappropriate Use of Oral Anticoagulants for Patients With Atrial Fibrillation.
Conclusions:The Fushimi AF Registry provides a unique snapshot of current AF management in an urban community in Japan. The present study reveals inappropriate use of OAC for patients with AF, indicating discordance between guideline recommendations and real-world clinical practice. PMID: 24976391 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 27, 2014 Category: Cardiology Authors: Akao M, Chun YH, Esato M, Abe M, Tsuji H, Wada H, Hasegawa K Tags: Circ J Source Type: research

Current Status and Outcomes of Direct Oral Anticoagulant Use in Real-World Atrial Fibrillation Patients 　- Fushimi AF Registry.
CONCLUSIONS: In real-world clinical practice, there were no significant differences in stroke/SE events or major bleeding events for DOAC compared with warfarin in patients with AF. PMID: 28428449 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 19, 2017 Category: Cardiology Authors: Yamashita Y, Uozumi R, Hamatani Y, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Ogawa H, Abe M, Morita S, Akao M Tags: Circ J Source Type: research

Comparative Safety and Effectiveness of Apixaban vs. Warfarin in Oral Anticoagulant-Na ïve Japanese Patients With Non-Valvular Atrial Fibrillation　- A Retrospective Chart Review Study
CONCLUSIONS: The benefit of apixaban over warfarin for the reduction in risk of major bleeding and stroke/SE could be generalizable to daily clinical practice and to patients with reduced renal function.PMID:34897136 | DOI:10.1253/circj.CJ-21-0682
Source: Circulation Journal - December 13, 2021 Category: Cardiology Authors: Yukihiro Koretsune Haruhiko Hoshino Yukako Matsuo Tatsuki Ibuki Takeshi Morimoto Source Type: research

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants vs. Warfarin in Japanese Patients With Atrial Fibrillation.
Conclusions:NOAC are more efficacious than warfarin for the prevention of stroke and systemic embolism in Japanese patients with NVAF. The present findings offer clinicians a more comprehensive picture of NOAC as a therapeutic option to reduce the risk of stroke in Japanese NVAF patients. PMID: 25501801 [PubMed - as supplied by publisher]
Source: Circulation Journal - December 11, 2014 Category: Cardiology Authors: Senoo K, Lau YC, Dzeshka M, Lane D, Okumura K, Lip GY Tags: Circ J Source Type: research

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