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A practical approach to the new oral anticoagulants used for stroke prevention in patients with atrial fibrillation.
Authors: Bashir S, Al-Mohammed A, Gupta S Abstract This review evaluates the research undertaken in the last six years on the use of new oral anticoagulants for stroke prevention in atrial fibrillation and provides evidence-based answers to common clinical questions. Two types of new oral anticoagulants - direct thrombin (IIa) inhibitors, and Xa inhibitors - are currently available. These drugs have similar pharmacokinetics and pharmacodynamics. They are more predictable than, though in many respects comparable to, warfarin. They do not require frequent laboratory tests, nor do they have a narrow therapeutic window...
Source: Journal of the Royal College of Physicians of Edinburgh - December 10, 2016 Category: Journals (General) Tags: J R Coll Physicians Edinb Source Type: research

Incidence, outcome and future projections of atrial fibrillation-related stroke and systemic embolism at age >=80 years: 10-year results of a population-based study
Conclusion Numbers of AF–related ischaemic strokes at age ≥80 years are projected to treble by 2050, along with numbers of systemic emboli, unless rates of anticoagulation in older patients increase.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Yiin, G. S., Howard, D. P., Paul, N. L., Mehta, Z., Rothwell, P. M. Tags: Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research