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Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study
CONCLUSION: Among those at low baseline stroke risk, people receiving OACs had a lower risk of testing positive for SARS-CoV-2 and severe COVID-19 outcomes than non-users; this might be explained by a causal effect of OACs in preventing severe COVID-19 outcomes or unmeasured confounding, including more cautious behaviours leading to reduced infection risk.PMID:35440465 | DOI:10.3399/BJGP.2021.0689
Source: The British Journal of General Practice - April 20, 2022 Category: Primary Care Authors: Angel Ys Wong Laurie Tomlinson Jeremy P Brown William Elson Alex J Walker Anna Schultze Caroline E Morton David Evans Peter Inglesby Brian MacKenna Krishnan Bhaskaran Christopher T Rentsch Emma Powell Elizabeth Williamson Richard Croker Seb Bacon William Source Type: research

CO33 Methodological Challenges and Considerations for Decision Makers When Assessing within-Class Comparative Effectiveness and Cost-Effectiveness: The Case of Non-Vitamin K Antagonist Oral Anticoagulants
The United Kingdom National Institute of Health Care Excellence (NICE) published a draft clinical guideline for consultation on anticoagulation therapy for stroke prevention in individuals with atrial fibrillation in September 2020 that addressed which non-vitamin K antagonist oral anticoagulant (NOAC) therapy (apixaban, dabigatran, rivaroxaban, edoxaban) is most clinically and cost-effective. We aimed to elucidate methodological considerations and challenges involved in evaluating the comparative effectiveness and cost-effectiveness of within-class treatments for the  purpose of decision making by a reimbursement authority.
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: A Briggs, A Howarth, S Davies, J Schneider, G Spentzouris, F Mughal, A Fuat, M Fay Source Type: research

Barriers and enablers to healthcare system uptake of direct oral anticoagulants for stroke prevention in atrial fibrillation: a qualitative interview study with healthcare professionals and policy makers in England
Conclusions The findings contribute to the wider literature by providing a new and in-depth understanding on the uptake of DOACs. The findings may be applicable to other new medicines used in chronic health conditions.
Source: BMJ Open - April 25, 2023 Category: General Medicine Authors: Medlinskiene, K., Richardson, S., Petty, D., Stirling, K., Fylan, B. Tags: Open access, Qualitative research Source Type: research

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