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Comparison of Echocardiographic Parameters of Left Atrial and Ventricular Function between Young Stroke vs Lone Atrial Fibrillation vs Healthy Controls
Background: Stroke is one of Australia's leading causes of morbidity and mortality with a significant percentage classified as cryptogenic. The nature and aetiology of cryptogenic stroke remains elusive, with a proportion believed to be cardio-embolic secondary to subclinical paroxysmal atrial fibrillation (AF). We aim to gain mechanistic insights into the pathophysiology of cryptogenic stroke in the young by comparing cardiac structural and functional differences in patients with young stroke, lone AF and healthy controls.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Bhat, S. Khanna, H. Chen, G. Gan, R. MacIntyre, T. Tan Tags: 254 Source Type: research

Is Incorrect Anti-Coagulation Dosing Contributing to Ischaemic Stroke Burden? A Retrospective Single-Centre Study from Regional New South Wales, Australia
Background: Atrial fibrillation (AF) contributes to 30% of ischaemic stroke presentations. Low doses of anti-coagulants are often prescribed to prevent stroke but ameliorate bleeding risk.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: P. Bamford, M. Ray, S. Cheruvu, M. Parkinson, C. Said, J. Trappel, J. Rogers Tags: 195 Source Type: research

Time Trends in Stroke Risk Management Among Patients With Atrial Fibrillation in Australia Between 2011 –2019
This study examined management among Australian patients between 2011 –2019.
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: K. Giskes, N. Lowres, J. Orchard, K. Hyun, C. Hespe, B. Freedman Source Type: research

Underusage of Oral Anticoagulation in Atrial Fibrillation: Can We Prevent More Strokes?
Atrial fibrillation (AF) is the most common sustained arrhythmia in Australia, affecting 2% of the population, and 6% of those over the age of 55 years [1]. The greatest contributor to morbidity and mortality in AF is its association with ischaemic stroke [2]. AF increases the risk of cardioembolic stroke five-fold, with an annual incidence of up to 7% [3]. There have been several validated tools developed to help individualise stroke risk, such as the CHADS2 [4], CHA2DS2-VASc [5], and more recently the CHA2DS2-VA score [6], all of which require the input of several vascular risk factors.
Source: Heart, Lung and Circulation - June 2, 2021 Category: Cardiology Authors: Karan Rao, Ravinay Bhindi Tags: Editorial Source Type: research

NOACs Now Mainstream for the Use of Anticoagulation in Non-Valvular Atrial Fibrillation in Australia.
The management of stroke risk in patients with non-valvular atrial fibrillation has changed over the past few years. This change has occurred due to the introduction of novel oral anticoagulants (NOACs) such as apixaban, rivaroxaban and dabigatran for the management of non-valvular atrial fibrillation. These agents have shown comparable stroke risk reduction to warfarin in large international multicentre trials [1 –3]. This has changed the clinical practice of many treating physicians since their introduction from 2011 to 2013.
Source: Heart, Lung and Circulation - March 22, 2018 Category: Cardiology Authors: Derk Pol, Claire Curtis, Satish Ramukumar, Logan Bittinger Tags: Brief Communication Source Type: research

NOACs Now Mainstream for the Use of Anticoagulation in Non-Valvular Atrial Fibrillation in Australia
The management of stroke risk in patients with non-valvular atrial fibrillation has changed over the past few years. This change has occurred due to the introduction of novel oral anticoagulants (NOACs) such as apixaban, rivaroxaban and dabigatran for the management of non-valvular atrial fibrillation. These agents have shown comparable stroke risk reduction to warfarin in large international multicentre trials [1 –3]. This has changed the clinical practice of many treating physicians since their introduction from 2011 to 2013.
Source: Heart, Lung and Circulation - March 22, 2018 Category: Cardiology Authors: Derk Pol, Claire Curtis, Satish Ramukumar, Logan Bittinger Tags: Brief Communication Source Type: research

Atrial Fibrillation and Indigenous Australians: A way Forward for Timely and Effective Screening and Treatment
Background: The leading cause of death for Indigenous Australians is cardiovascular disease, including stroke. Atrial Fibrillation (AF) increases stroke risk 5 –7 fold. Early detection and treatment of AF in Caucasians has proven feasible. Aim: To estimate AF prevalence in community settings and examine feasibility of using a handheld single-lead ECG device (iECG) for Indigenous Australians.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: K. Gwynne, J. Gwynn, H. Finlayson, S. Hamilton, M. Lawrence, R. MacNiven, L. Neubeck, B. Rambaldini, R. Rodrigues, K. Taylor, S. Thompson, B. Freedman Tags: 514 Source Type: research

Predictors of Anticoagulation Use in Indigenous and Non-Indigenous Australians with Atrial Fibrillation
Prior studies have demonstrated that anticoagulation underutilisation for atrial fibrillation (AF) and elevated stroke risk is common. However, there is little data on factors associated with appropriate anticoagulation, particularly in Indigenous Australians who face a disproportionate burden of AF and stroke. We thus sought to determine factors associated with anticoagulation use in Australians with AF.
Source: Heart, Lung and Circulation - October 29, 2020 Category: Cardiology Authors: Simon Rocheleau, Celine Gallagher, Bradley M. Pitman, Samuel J. Tu, Nicole Hanna-Rivero, Nicholas Clarke, Dominik Linz, Jeroen M. Hendriks, Melissa E. Middeldorp, Rajiv Mahajan, Dennis H. Lau, Kurt C. Roberts-Thomson, Prashanthan Sanders, Christopher X. W Tags: Original Article Source Type: research

Oral Anticoagulant Use in Patients With Atrial Fibrillation and Chronic Kidney Disease: A Review of the Evidence With Recommendations for Australian Clinical Practice
Chronic kidney disease is common in patients with atrial fibrillation (AF) and is associated with heightened risks of stroke/systemic embolisation and bleeding. In this review we outline the evidence for AF stroke prevention in kidney disease, identify current knowledge gaps, and give recommendations for anticoagulation at various stages of chronic kidney disease.Overall, anticoagulation is underused. Warfarin use becomes increasingly difficult with advancing kidney disease, with difficulty maintaining international normalised ratio (INR) in therapeutic range, increased risk of intracranial and fatal bleeding compared to n...
Source: Heart, Lung and Circulation - November 3, 2022 Category: Cardiology Authors: Christopher Hammett, Sunil V. Badve, Peter G. Kerr, Huyen A. Tran, Benjamin K. Dundon, Sidney Lo, Andrew Wong, Joanne E. Joseph, Jenny Deague, Vlado Perkovic Tags: Review Source Type: research

Older People With Atrial Fibrillation and Hypertension Are at Higher Risk of Poor Blood Pressure Control in Australian Primary Care
This study explored factors that influence BP control in AF patients with hypertension managed in Australian primary care, with a focus on older age.
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: R. Trivedi, T. Shaw, C. Chow, L. Laranjo Source Type: research

Pioneering Australia ’s First Atrial Fibrillation Guidelines
Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice, and has a major impact on morbidity and mortality; linked to one in 12 deaths in Australia [2]. Though appropriate rhythm management and stroke prevention are essential, arguably, prevention is likely to achieve the greatest impact on these outcomes. These Australian-first guidelines [1], developed by the Heart Foundation and the Cardiac Society of Australia and New Zealand, incorporate the latest contemporary evidence in AF prevention by recommending a holistic approach.
Source: Heart, Lung and Circulation - November 1, 2018 Category: Cardiology Authors: Cia Connell, Garry L.R. Jennings Tags: Editorial Source Type: research

Stroke Risk Stratification: CHA2DS2-VA or CHA2DS2-VASc?
It is with interest that we note the letter by Drs Overvad and colleagues in which concern is expressed regarding a newly proposed strategy in the recently published Australian Guidelines for Atrial Fibrillation (AF) [1]. Specifically we recommend that female sex category be dropped from the CHA2DS2-VASc score; therefore recommending a CHA2DS2-VA score.
Source: Heart, Lung and Circulation - March 30, 2019 Category: Cardiology Authors: David Brieger, Cia Connell, Ben Freedman Tags: Letter to the Editor Source Type: research

First Australian Experience with Total Thoracoscopic Left Atrial Appendage Occlusion with Atriclip PRO2 device
We describe the first Australian series of totally thoracoscopic external LAA occlusion with the Atriclip PRO2TM device.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: P. Joshi, P. Sadlier, R. Weerasooriya, D. Playford Tags: 466 Source Type: research

Trends in the Use of Warfarin and Novel Oral Anticoagulants in Australia, 2013 to 2017
Background: In 2013, novel oral anticoagulants (NOACs) were added to the PBS as alternatives to warfarin for stroke prevention in atrial fibrillation (AF). Aim of this study is to examine changes in the use of oral anticoagulants (OACs) since the introduction of NOACs.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: A. Dina, T. Akindele Tags: 231 Source Type: research

Quality of Warfarin Anticoagulation in Indigenous and Non-Indigenous Australians With Atrial Fibrillation
Studies have shown that suboptimal anticoagulation quality, as measured by time in therapeutic range (TTR), affects a significant percentage of patients with atrial fibrillation (AF). However, TTR has not been previously characterised in Indigenous Australians who experience a greater burden of AF and stroke.
Source: Heart, Lung and Circulation - November 27, 2019 Category: Cardiology Authors: Mau T. Nguyen, Celine Gallagher, Bradley M. Pitman, Mehrdad Emami, Kadhim Kadhim, Jeroen M. Hendriks, Melissa E. Middeldorp, Kurt C. Roberts-Thomson, Rajiv Mahajan, Dennis H. Lau, Prashanthan Sanders, Christopher X. Wong Tags: Original Article Source Type: research

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