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Specialty: Physiology
Condition: Ataxia
Nutrition: Diets
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Total 6 results found since Jan 2013.
Deficiency of Ataxia-Telangiectasia Mutated Kinase Modulates Functional and Biochemical Parameters of the Heart in Response to Western-type Diet
Am J Physiol Heart Circ Physiol. 2021 Apr 30. doi: 10.1152/ajpheart.00990.2020. Online ahead of print.ABSTRACTAtaxia telangiectasia mutated kinase (ATM) deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, while cardiac functional and biochemical parameters were measured 14 weeks post-WD. hKO-WD mice exhibited rapid body weigh...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 30, 2021 Category: Physiology Authors: Mary C Wingard Suman Dalal Paige L Shook Rachel Myers Barbara A Connelly Douglas P Thewke Mahipal Singh Krishna Singh Source Type: research
