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Outcomes in nonagenarians undergoing transcatheter aortic valve implantation (TAVI): data from a nationwide analysis.
CONCLUSIONS: Within nonagenarians with AS, patients treated with TAVI had lower risk of cardiovascular events than matched patients treated medically. The patients undergoing a TAVI at this age were often highly selected and the procedure was associated with acceptable long term outcomes. PMID: 31763981 [PubMed - as supplied by publisher]
Source: EuroIntervention - November 27, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Meta-Analysis of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in patients at Low Surgical Risk.
CONCLUSIONS: in patients who are at low surgical risk, TAVI seems to be associated with equivalent mortality up to a median follow up of 2 years compared to SAVR. More data is required before TAVI can be routinely considered as an alternative for SAVR in low risk patients. PMID: 31566571 [PubMed - as supplied by publisher]
Source: EuroIntervention - October 1, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Early Hemodynamic Changes and Long-Term Outcome Of Patients With Severe Low Gradient Aortic Stenosis After Transcatheter Aortic Valve Replacement.
CONCLUSIONS: NFLG-AS was the most prevalent form of LG severe AS and was associated with adequate left ventricular compensation and good prognosis. On the other hand, CLFLG-AS represents the heart-failure with reduced ejection fraction (HFrEF) form of AS and was associated with the worst prognosis, whereas PLFLG-AS represents the heart-failure with preserved ejection fraction (HFpEF) form of AS with intermediary prognosis. Both groups showed early hemodynamic reverse response after TAVR. PMID: 31566569 [PubMed - as supplied by publisher]
Source: EuroIntervention - October 1, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Transcatheter Aortic Valve Implantation using ACURATE neo in bicuspid and tricuspid aortic valve stenosis: a propensity matched analysis of an European experience.
CONCLUSIONS: this preliminary analysis shows that the use of ACURATE neo in bicuspid aortic valves is feasible and has acceptable 30-days outcome. Larger studies are needed to confirm our preliminary findings. PMID: 30375336 [PubMed - as supplied by publisher]
Source: EuroIntervention - November 1, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

TAVI and the brain: update on definitions, evidence of neuroprotection and adjunctive pharmacotherapy.
Authors: Lansky A, Ghare MI, Tchétché D, Baumbach A Abstract Transcatheter aortic valve implantation (TAVI) has become the preferred method of treatment for high-risk patients with severe symptomatic aortic stenosis (AS) and is a preferred alternative to surgical valve replacement for intermediate-risk patients. Stroke remains one of the most clinically devastating complications following TAVI. We review the incidence of neurologic injury related to TAVI, proposed definitions for neurologic events and current evidence for neuroprotection and adjunctive pharmacotherapy. PMID: 30158096 [PubMed - in process]
Source: EuroIntervention - August 31, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Early commercial experience from transcatheter aortic valve implantation using the Portico ™ bioprosthetic valve: 30-day outcomes in the multicentre PORTICO-1 study.
CONCLUSIONS: The Portico TAVI system allows safe and effective treatment of aortic stenosis in patients at increased surgical risk. At 30 days, mortality was low, and good haemodynamic performance was indicated by low transvalvular gradient and a low rate of moderate or higher PVL. PMID: 30111522 [PubMed - as supplied by publisher]
Source: EuroIntervention - August 17, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

One-year outcomes of patients with severe aortic stenosis and an STS-PROM of less than three percent in the SURTAVI trial.
CONCLUSIONS: Among patients at intermediate surgical risk but with STS PROM<3%, TAVI may achieve superior clinical outcomes compared to SAVR. These findings support the need for an adequately powered randomized trial to compare TAVI with SAVR in patients at low operative risk. PMID: 29992904 [PubMed - as supplied by publisher]
Source: EuroIntervention - July 12, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Transcatheter aortic valve implantation with the self-expanding Portico ™ valve system in an all-comers population: procedural and clinical outcomes.
CONCLUSIONS: The PorticoTM TAVI system was safe to implant and achieved a high device success rate. With learning curve effects, the device achieves lower rates of PVL and pacemaker implantation and provides adequate clinical and hemodynamic outcomes through 1 year. PMID: 29969432 [PubMed - as supplied by publisher]
Source: EuroIntervention - July 5, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Novel Predictors of Mild Paravalvular Aortic Regurgitation in SAPIEN 3 Transcatheter Aortic Valve Implantation.
CONCLUSIONS: LVOT eccentricity and discordant sizing predict PVL after S3 TAVI. Further studies are needed to understand their mechanism and significance. PMID: 29488887 [PubMed - as supplied by publisher]
Source: EuroIntervention - March 2, 2018 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Real-world experience using the ACURATE neo ™ prosthesis: 30-day outcomes of 1000 patients enrolled in the SAVI-TF registry.
CONCLUSIONS: In this initial experience, treatment with the ACURATE neoTM prosthesis resulted in excellent clinical outcomes with very low complication rates. PMID: 29131801 [PubMed - as supplied by publisher]
Source: EuroIntervention - November 15, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Characteristics and Outcome Following Transcatheter Aortic Valve Replacement of Patients with Severe Aortic Stenosis with Low Flow.
CONCLUSIONS: Patients with HG and those with NF-LG have low 1-year mortality rates following TAVR, whereas those with classical LF-LG and LEF and those with paradoxical LF-LG and NEF have high and intermediate risk of mortality, respectively. In contradiction to previous reports, LG but not LF or LEF is an independent predictor of late mortality in high-risk patients with severe AS undergoing TAVR. PMID: 28870874 [PubMed - as supplied by publisher]
Source: EuroIntervention - September 7, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Repositionable Percutaneous Aortic Valve Implantation with the Lotus Valve: 30-Day and 1-Year Outcomes in 250 High-Risk Surgical Patients.
CONCLUSIONS: Lotus Valve implantation produced excellent valve haemodynamics, minimal PVL, sustained significant improvement in functional status, and good clinical outcomes 1 year post-implant. PMID: 28555592 [PubMed - as supplied by publisher]
Source: EuroIntervention - June 1, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Long-term outcomes after TAVI in patients with different types of aortic stenosis - The conundrum of low flow, low gradient and low ejection fraction.
CONCLUSIONS: These findings suggest that an assessment of LV-EF alone for outcome prediction after TAVI is inadequate: it is the guideline-defined subtype of AS that determines outcome. PMID: 28462903 [PubMed - as supplied by publisher]
Source: EuroIntervention - May 4, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Combined Erythropoietin and Iron Therapy for Anemic Patients Undergoing Transcatheter Aortic Valve Replacement: The EPICURE Randomized Clinical Trial.
CONCLUSIONS: EPO administration failed to reduce RC transfusion rate or the per-patient number of transfusion units in anemic patients undergoing TAVI. PMID: 28067195 [PubMed - as supplied by publisher]
Source: EuroIntervention - January 12, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Multicentre clinical study evaluating a novel resheathable annular functioning self-expanding transcatheter aortic valve system: safety and performance results at 30 days with the Portico system.
CONCLUSIONS: The novel Portico TAVI system is safe and effective at treating high-risk patients with symptomatic severe aortic stenosis, allowing safe repositioning and optimisation of device position. PMID: 27542790 [PubMed - in process]
Source: EuroIntervention - August 22, 2016 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

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