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Source: International Journal of Cardiology
Condition: Aortic Stenosis
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Total 20 results found since Jan 2013.
Diastolic dysfunction reduces stroke volume during daily's life activities in patients with severe aortic stenosis
Pathophysiologic consequences of left ventricular (LV) hypertrophy and fibrosis, as these occur in aortic stenosis, are elevated filling and left atrial (LA) pressures [1]. Depending on the time duration of pressure overload, LA volume increases proportionally to the degree of left ventricular (LV) diastolic dysfunction [2]. Elevated LA pressure aims to ensure adequate LV filling and, consequently, stroke volume but may return to normal levels during certain daily activities (e.g., cough, defecation, lifting a heavy or even medium load), which produce a preload reduction, possibly compromising LV both filling and stroke volume [1].
Source: International Journal of Cardiology - May 20, 2015 Category: Cardiology Authors: Maria Angela Losi, Raffaele Izzo, Eugenio Stabile, Anna Sannino, Grazia Canciello, Alessandra Giamundo, Francesca Musella, Plinio Cirillo, Mariella Prastaro, Maurizio Galderisi, Bruno Trimarco, Giovanni Esposito Tags: Letter to the Editor Source Type: research
Impact of stroke volume assessment by integrating multi-detector computed tomography and Doppler data on the classification of aortic stenosis
The prevalence of low flow low gradient (LFLG) severe aortic stenosis (AS) may be overrated due to underestimation of stroke volume in two-dimensional (2D) echocardiography. The implications of 3D imaging on stroke volume calculation for AS classification have not been elucidated. Integrating multi-detector computed tomography (MDCT) and Doppler data may improve diagnostic accuracy in patients with LFLG AS.
Source: International Journal of Cardiology - September 1, 2017 Category: Cardiology Authors: Barbara E. St ähli, Thomas Stadler, Erik W. Holy, Thi Dan Linh Nguyen-Kim, Lisa Hoffelner, Ladina Erhart, Slayman Obeid, Markus Niemann, Rolf Jenni, Sandra Hamada, Robert Manka, Thomas F. Lüscher, Francesco Maisano, Fabian Nietlispach, Thomas Frauenfeld Source Type: research
Allometric versus ratiometric normalization of left ventricular stroke volume by Doppler-echocardiography for outcome prediction in severe aortic stenosis with preserved ejection fraction
Appropriate normalization methods to scale Doppler-derived stroke volume (SV) to body size in patients with aortic stenosis (AS) are poorly defined and reference values are lacking. We aim to establish reference values of normalized SV in adults, and to compare the prognostic value of SV normalized by different methods in AS patients.
Source: International Journal of Cardiology - October 8, 2019 Category: Cardiology Authors: Dan Rusinaru, Ernst R. Rietzschel, Yohann Bohbot, Marc L. De Buyzere, Otilia Buiciuc, Sylvestre Mar échaux, Thierry C. Gillebert, Christophe Tribouilloy Source Type: research
Implementation of a CT-derived correction factor to refine the measurement of aortic valve area and stroke volume using Doppler echocardiography improves grading of severity and prediction of prognosis in patients with severe aortic stenosis
Aims: To assess rates of reclassification of severity and associated 5-year survival in patients with severe aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF) after application of a CT-derived correction factor (CF) to refine the measurement of aortic valve area (AVA) and stroke volume index (SVi) using Doppler echocardiography.Methods and Results: We enrolled 1450 patients with severe AS and preserved LVEF from a French registry. Multiplication of echocardiographic LV outflow tract diameter by a CT-derived CF of 1.13 to calculate the AVA and SVi using the continuity equation resulted in reclassi...
Source: International Journal of Cardiology - June 15, 2022 Category: Cardiology Authors: Attila Kardos, Dan Rusinaru, Sylvestre Mar échaux, Ebraham Alskaf, Bernard Prendergast, Christophe Tribouilloy Source Type: research
Time to peak velocity of aortic flow is useful in predicting severe aortic stenosis
Echocardiography has been the gold standard method to evaluate the severity of aortic valvular stenosis (AS) in clinical practice. The calculation of aortic valve area (AVA) by continuity equation is reliable and has been extensively studied in past publications . To get the correct AVA by continuity equation, the following parameters must be reliably measured: 1) left ventricular (LV) outflow tract (LVOT) diameter (LVOTd); 2) pulsed wave Doppler signal of the blood flow in the LVOT; and 3) continuous wave Doppler signal of the blood flow at the stenotic aortic valve . However, these measurements could not always be satisf...
Source: International Journal of Cardiology - February 3, 2014 Category: Cardiology Authors: Sung Hea Kim, Je Sang Kim, Bum Sung Kim, Jinoh Choi, Sang-Chol Lee, Jae K. Oh, Seung Woo Park Tags: Online Letters to the Editor Source Type: research
Prognostic importance of atrial fibrillation in asymptomatic aortic stenosis: The Simvastatin and Ezetimibe in Aortic Stenosis study
Conclusion: Rate of AF is moderate in asymptomatic AS. Longstanding but not episodic AF was, independently predictive of increased risk of heart failure and non-hemorrhagic stroke. New-onset AF was associated with cardiac decompensation.
Source: International Journal of Cardiology - October 13, 2011 Category: Cardiology Authors: Anders M. Greve, Eva Gerdts, Kurt Boman, Christa Gohlke-Baerwolf, Anne B. Rossebø, Christoph A. Nienaber, Simon Ray, Kenneth Egstrup, Terje R. Pedersen, Lars Køber, Ronnie Willenheimer, Kristian Wachtell Tags: Original Articles Source Type: research
Left atrial size and function as predictors of new-onset of atrial fibrillation in patients with asymptomatic aortic stenosis: The simvastatin and ezetimibe in aortic stenosis study
Abstract: Background: Left atrial (LA) size and function change with chronically increased left ventricular (LV) filling pressures. It remains unclear whether these variations in LA parameters can predict new-onset atrial fibrillation (AF) in asymptomatic patients with aortic stenosis (AS).Methods: Data were obtained in asymptomatic patients with mild-to-moderate AS (2.5≤ transaortic Doppler velocity ≤4.0m/s), preserved LV ejection fraction (EF), no previous AF, and were enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study. Peak-aortic velocity, LAmax volume & LAmin volume were measured by echocardiograph...
Source: International Journal of Cardiology - February 18, 2013 Category: Cardiology Authors: Casper N. Bang, Morten Dalsgaard, Anders M. Greve, Lars Køber, Christa Gohlke-Baerwolf, Simon Ray, Anne B. Rossebø, Kenneth Egstrup, Kristian Wachtell Tags: Original Articles Source Type: research
Accentuated left ventricular lateral wall function compensates for septal dyssynchrony after valve replacement for aortic stenosis
Abstract: Background: The interventricular septal motion becomes reversed after aortic valve replacement (AVR) for aortic stenosis (AS) despite maintained stroke volume (SV). We hypothesis that left ventricular (LV) lateral wall compensates for such disturbances, in order to secure normal SV.Methods: We studied 29 severe AS patients (age 63±11years, 18 males) with normal ejection fraction (EF) before, 6months and 12months after AVR and compared them with 29 age- and gender-matched controls, using speckle tracking echocardiography.Results: In patients, the LVEF and SV remained unchanged throughout. Before AVR, the septal r...
Source: International Journal of Cardiology - August 2, 2011 Category: Cardiology Authors: Ying Zhao, Per Lindqvist, Anders Holmgren, Michael Y. Henein Tags: Original Articles Source Type: research
Early and mid-term cardiovascular outcomes following TAVI: Impact of pre-procedural transvalvular gradient
Abstract: Objective: To assess the relation of aortic transvalvular gradient with outcomes following transcatheter aortic valve implantation (TAVI).Background: Relatively little is known about the predictors of adverse outcomes in patients with severe aortic stenosis following TAVI.Methods: We studied 126 consecutive patients (mean age 83.2±6.3years; 59% women) who underwent TAVI (23% transapical; 77% transfemoral) at our institution. All patients were followed for the incidence of major adverse cardiovascular events (MACE), including myocardial infarction, heart failure, stroke, and cardiovascular death.Results: The acut...
Source: International Journal of Cardiology - March 29, 2012 Category: Cardiology Authors: Nicolas Amabile, Ramzi Ramadan, Said Ghostine, Susan Cheng, Alexandre Azmoun, François Raoux, Ngoc-Tram To, Yacine Haddouche, Xavier Troussier, Remi Nottin, Christophe Caussin Tags: Original Articles Source Type: research
Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: Results from an intermediate risk propensity-matched population of the Italian OBSERVANT study
Conclusions: Patients undergoing transcatheter and surgical treatment of severe aortic stenosis are still extremely distinct populations. In the relatively low-risk propensity-matched population analyzed, despite similar procedural and 30-day mortality, SAVR was associated with a higher risk for blood transfusion, whereas TAVI showed a significantly increased rate of vascular damage, permanent AV block and residual aortic valve regurgitation.
Source: International Journal of Cardiology - May 28, 2012 Category: Cardiology Authors: Paola D'Errigo, Marco Barbanti, Marco Ranucci, Francesco Onorati, Remo Daniel Covello, Stefano Rosato, Corrado Tamburino, Francesco Santini, Gennaro Santoro, Fulvia Seccareccia, on behalf of the OBSERVANT Research Group Tags: Original Articles Source Type: research
Impact of global hemodynamic load on exercise capacity in aortic stenosis
Abstract: Background: The determinants of maximal exercise capacity (MEC) in aortic stenosis (AS) are, in large part, unknown. We hypothesized that the left ventricular (LV) global hemodynamic load – as assessed by the valvulo-arterial impedance (Zva) – is one of the main determinants of MEC and we sought to evaluate the factors associated with reduced MEC in AS.Method and results: Asymptomatic patients with moderate or severe AS (n=62, aortic valve area 50%) were prospectively referred for comprehensive resting echocardiography and cardiopulmonary exercise test. Absolute peak VO2 was 19.5±5.7mL/kg/min (median 19.6mL/...
Source: International Journal of Cardiology - March 1, 2013 Category: Cardiology Authors: R. Dulgheru, J. Magne, R. Capoulade, L. Davin, D. Vinereanu, L.A. Pierard, P. Pibarot, P. Lancellotti Tags: Original Articles Source Type: research
MSCT guided sizing of the Edwards Sapien XT TAVI device: Impact of different degrees of oversizing on clinical outcome
Abstract: Aims: Prospective data on the usage of 3-dimensional imaging based annulus sizing on the outcome of TAVI is not available yet and there is general uncertainty about the optimal degree of oversizing. In the current study we therefore assessed a 3-D MSCT guided over-sizing approach and evaluated the clinical outcome of different degrees of oversizing.Methods: TAVI-size-selection was done using systolic MSCT-annulus cross-sectional-area (CSA) measurements in 107 patients with severe aortic stenosis with the goal to oversize the 3rd generation balloon expandable Edwards Sapien XT (ESTV) device in relation to the nati...
Source: International Journal of Cardiology - April 15, 2013 Category: Cardiology Authors: A.W. Leber, W. Eichinger, J. Rieber, M. Lieber, S. Schleger, U. Ebersberger, M. Deichstetter, J. Vogel, T. Helmberger, D. Antoni, G. Riess, E. Hoffmann, A.M. Kasel Tags: Original Articles Source Type: research
The Ibero-American transcatheter aortic valve implantation registry with the CoreValve prosthesis. Early and long-term results
Conclusions: Transcatheter aortic valve implantation constitutes a safe and viable therapeutic option for high operative risk patients with severe aortic stenosis. Long-term prognosis is conditioned by associate comorbidities.
Source: International Journal of Cardiology - October 15, 2013 Category: Cardiology Authors: Antonio J. Muñoz-García, Raquel del Valle, Ramiro Trillo-Nouche, Jaime Elízaga, Federico Gimeno, Rosana Hernández-Antolín, Rui Teles, Vasco de Gama Ribeiro, Eduardo Molina, Ángel Cequier, Cristóbal Urbano-Carrillo, Ignacio Cruz-González, Miguel Pa Tags: Original Articles Source Type: research
Successful management of a twice complicated case by implantation of three CoreValve prostheses
An 80year old man, diabetic on oral medication and with permanent atrial fibrillation with a single chamber pacemaker, was referred to our hospital for severe symptomatic aortic valve stenosis. His trans-thoracic echocardiography confirmed severe aortic stenosis with a mean/peak gradient of 45/85mmHg, an estimated aortic valve area of 0.7cm2 and good systolic function with an ejection fraction of 50%. His past medical history was remarkable for a minor stroke without neurological impairment and moderate kidney dysfunction with creatinine of 2.3mg/dL. A cardiac catheterization revealed no obstructive coronary heart disease.
Source: International Journal of Cardiology - January 27, 2014 Category: Cardiology Authors: George Latsios, Kostantinos Toutouzas, Dimitris Tousoulis, Andreas Synetos, Antonios Mastrokostopoulos, Konstantinos Stathogiannis, Themis Spyridopoulos, Ulrich Gerckens, Christodoulos Stefanadis Tags: Letters to the Editor Source Type: research
Echo-doppler and invasive evaluation of valvulo-arterial impedance in patients with severe aortic stenosis: Impact of pressure recovery
Aortic stenosis (AS) is the most frequent valvulopathy in the western population [1]. Guidelines reported eco-Doppler mean (MG) and peak (PG) gradient and valve area (AVA) as index to its quantitative evaluation [2]. However, they seem inadequate to a correct severity definition [3] and new parameters, such as valvulo-arterial impedance (Zva), an index of global LV afterload, which theoretically accounts for the effects of AS and systemic arterial compliance [4], have been proposed [5]. Zva is obtained as the ratio of stroke volume index (SVI) to the sum of systolic arterial pressure (SAP) and MG [6] and for its correct e...
Source: International Journal of Cardiology - October 24, 2014 Category: Cardiology Authors: Corinna Bergamini, Giorgio Golia, Aldo D. Milano, Matteo Pernigo, Francesca Vassanelli, Gabriele Pesarini, Giuseppe Faggian, Corrado Vassanelli Tags: Letter to the editor Source Type: research
