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Usefulness of the CHA2DS2-VASc Score to Predict Outcome in Patients Who Underwent Transcatheter Aortic Valve Implantation
Risk assessment for transcatheter aortic valve implantation (TAVI) patients remains challenging, especially in elderly and high-risk candidates. Although several risk factors contribute to increased morbidity and mortality after TAVI, simple risk scores for routine use are lacking. Applying the CHA2DS2-VASC (congestive heart failure, hypertension, age  ≥ 75 years, diabetes, prior stroke, vascular disease, age 65–74 years, sex [female] category) score as a novel risk stratification tool for conditions other than atrial fibrillation and stroke prevention has been previously examined; however, its usefulness in a popu...
Source: The American Journal of Cardiology - October 19, 2017 Category: Cardiology Authors: Katia Orvin, Amos Levi, Uri Landes, Tamir Bental, Alexander Sagie, Yaron Shapira, Hana Vaknin-Assa, Abid Assali, Ran Kornowski Source Type: research

Transcatheter Aortic Valve Implantation Futility Risk Model Development and Validation among Treated Patients with Aortic Stenosis Patients
Risk-benefit assessment for transcatheter aortic valve implantation (TAVI) is still evolving. A sizeable group of patients do not fully benefit from intervention despite technically successful procedure. All patients who underwent TAVI with device success and with no VARC-2 defined complications were included. Various demographic data, clinical details and echocardiographic findings were examined. The outcome was defined as 1-year composite of mortality, stroke, lack of functional-class improvement (by NYHA class), and readmissions ( ≥1 month post procedure).
Source: The American Journal of Cardiology - September 15, 2017 Category: Cardiology Authors: Oren Zusman, Ran Kornowski, Guy Witberg, Adi Lador, Katia Orvin, Amos Levi, Abid Assali, Hana Vaknin-Assa, Ram Sharony, Yaron Shapira, Alexander Sagie, Uri Landes Source Type: research

Reliability of Aortic Stenosis Severity Classified by 3-Dimensional Echocardiography in the Prediction of Cardiovascular Events
The estimation of aortic valve area (AVA) by Doppler echocardiography-derived left ventricular stroke volume (LVSV) remains controversial. We hypothesized that AVA estimated from directly measured LVSV by 3-dimensional echocardiography (3DE) on the continuity equation might be more accurate in classifying aortic stenosis (AS) severity. We retrospectively enrolled 265 patients with moderate to severe AS with preserved ejection fraction. Indexed AVA (iAVA) was calculated using LVSV derived by 2D-Doppler (iAVADop), Simpson’s method (iAVASimp), and 3DE (iAVA3D).
Source: The American Journal of Cardiology - May 13, 2016 Category: Cardiology Authors: Kimi Sato, Yoshihiro Seo, Tomoko Ishizu, Hideki Nakajima, Masaaki Takeuchi, Masaki Izumo, Kengo Suzuki, Yoshihiro J. Akashi, Yutaka Otsuji, Kazutaka Aonuma Source Type: research

Meta-analysis of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in patients with Severe Aortic Valve Stenosis Patients
Transcatheter aortic valve replacement (TAVR) is a viable option in the treatment of severe aortic stenosis in patients at high risk for surgery. We sought to further investigate outcomes in low-to-intermediate-risk patients with aortic stenosis undergoing surgical aortic valve replacement (SAVR) versus TAVR. We systematically searched the electronic databases, MEDLINE, PUBMED, EMBASE and Cochrane for prospective cohort studies of the effects of TAVR vs SAVR on clinical outcomes (30-day mortality, all cause mortality, stroke and myocardial infarction [MI], major vascular complications, paravalvular regurgitation, permanent...
Source: The American Journal of Cardiology - November 5, 2015 Category: Cardiology Authors: Ashok Kondur, Alexandros Briasoulis, Mohan Palla, Anirudh Penumetcha, Sagar Mallikethi-Reddy, Apurva Badheka, Theodore Schreiber Source Type: research

Is Transcatheter Aortic Valve Implantation as Cost-effective as Surgical Aortic Valve Replacement?
Transcatheter aortic valve implantation (TAVI) has emerged as an efficacious and cost-effective treatment for inoperable patients with severe aortic stenosis.1 For high-risk patients, existing evidence suggests that TAVI has similar peri-procedural mortality and stroke outcomes compared to surgical aortic valve replacement (AVR), with higher incidences of paravalvular leak, permanent pacemaker requirement and vascular injuries after TAVI and higher incidences of major bleeding after AVR.2 Regarding the cost-effectiveness of TAVI, a recent systematic review examining its incremental cost effectiveness ratio in relation to A...
Source: The American Journal of Cardiology - July 16, 2015 Category: Cardiology Authors: Christopher Cao Source Type: research

Meta-analysis of the Prognostic Impact of Stroke Volume, Gradient, and Ejection Fraction After Transcatheter Aortic Valve Implantation
The prognostic implications of several baseline preprocedural variables in patients with severe native valve aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) are unclear. The goal of this study was to determine the impact of reduced stroke volume index (SVI), low gradient (LG), and reduced ejection fraction (EF) on all-cause mortality. We searched MEDLINE, CENTRAL, EMBASE, Web of Science, and Scopus through October 13, 2014. We evaluated the association between low SVI (
Source: The American Journal of Cardiology - June 25, 2015 Category: Cardiology Authors: Mackram F. Eleid, Kashish Goel, M. Hassan Murad, Patricia J. Erwin, Rakesh M. Suri, Kevin L. Greason, Rick A. Nishimura, Charanjit S. Rihal, David R. Holmes Tags: Review Source Type: research

Meta-Analysis of the Prognostic Impact of Stroke Volume, Gradient and Ejection Fraction Following Transcatheter Aortic Valve Implantation
The prognostic implications of several baseline pre-procedural variables in patients with severe native valve aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) are unclear. The goal of this study was to determine the impact of reduced stroke volume index (SVI), low gradient (LG) and reduced ejection fraction (EF) on all-cause mortality. We searched MEDLINE, CENTRAL, EMBASE, Web of Science, and Scopus through 10/13/2014. We evaluated the association between low SVI (
Source: The American Journal of Cardiology - June 25, 2015 Category: Cardiology Authors: Mackram F. Eleid, Kashish Goel, M. Hassan Murad, Patricia J. Erwin, Rakesh M. Suri, Kevin L. Greason, Rick A. Nishimura, Charanjit S. Rihal, David R. Holmes Source Type: research

Atrial Fibrillation, Stroke and Mortality Rates Following Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) is considered a suitable treatment for patients with severe symptomatic aortic stenosis (AS) and high operative risk. Our aim was to evaluate the effect of pre-procedural and new-onset atrial fibrillation (NOAF) on mortality and stroke in patients undergoing TAVI. We performed a single center study of 380 consecutive patients enrolled to a TAVI registry. NOAF was defined as post-procedural atrial fibrillation (AF) occurring within 30 days following the procedure.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Lior Yankelson, Arie Steinvil, Liron Gershovitz, Eran Leshem-Rubinow, Ariel Furer, Sami Viskin, Gad Keren, Shmuel Banai, Ariel Finkelstein Source Type: research

Atrial Fibrillation, Stroke, and Mortality Rates After Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) is considered a suitable treatment for patients with severe symptomatic aortic stenosis and high operative risk. Our aim was to evaluate the effect of preprocedural and new-onset atrial fibrillation (NOAF) on mortality and stroke in patients who underwent TAVI. We performed a single-center study of 380 consecutive patients enrolled to a TAVI registry. NOAF was defined as postprocedural atrial fibrillation (AF) occurring within 30 days after the procedure.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Lior Yankelson, Arie Steinvil, Liron Gershovitz, Eran Leshem-Rubinow, Ariel Furer, Sami Viskin, Gad Keren, Shmuel Banai, Ariel Finkelstein Tags: Valvular Heart Disease Source Type: research

Impact of Flow and Left Ventricular Strain on Outcome of Patients With Preserved Left Ventricular Ejection Fraction and Low Gradient Severe Aortic Stenosis Undergoing Aortic Valve Replacement
The prognostic implications of flow, assessed by stroke volume index (SVi), and left ventricular (LV) global longitudinal strain on survival of patients with low-gradient severe aortic stenosis (AS) and preserved LV ejection fraction are debated. The aim of this study was to evaluate the impact of flow and LV global longitudinal strain on survival in these patients treated with aortic valve replacement (AVR). Patients with low-gradient severe AS with preserved LV ejection fraction treated with AVR (n = 134, mean age 76 ± 10 years, 50% men) were included in the present study.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Vasileios Kamperidis, Philippe J. van Rosendael, Arnold C.T. Ng, Spyridon Katsanos, Frank van der Kley, Philippe Debonnaire, Emer Joyce, Georgios Sianos, Nina Ajmone Marsan, Jeroen J. Bax, Victoria Delgado Tags: Valvular Heart Disease Source Type: research

Relation Between Stroke Volume Index to Risk of Death in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Left Ventricular Function
The aim of the present study was to evaluate whether assessment of stroke volume index (SVI) can be used to improve risk stratification among patients with low-gradient severe aortic stenosis and preserved ejection fraction (EF). Study population comprised 409 patients with aortic valve area ≤1.00 cm2, mean gradient
Source: The American Journal of Cardiology - May 19, 2014 Category: Cardiology Authors: Elad Maor, Roy Beigel, Avishay Grupper, Rafael Kuperstein, Ilan Hai, Diego Medvedofsky, Olga Perelstein, Israel Mazin, Asaf Ziv, Ilan Goldenberg, Micha S. Feinberg, Sagit Ben Zekry Tags: Valvular Heart Disease Source Type: research

Outcome of Transcatheter Aortic Valve Implantation in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction
In conclusion, transcatheter aortic valve implantation appears to result in similar hemodynamic and long-term clinical outcomes for high-risk surgical patients with LGSAS as those with typical severe AS.
Source: The American Journal of Cardiology - November 8, 2013 Category: Cardiology Authors: Simon Biner, Edo Yaakov Birati, Yan Topilsky, Arie Steinvil, Eyal Ben Assa, Ben Sadeh, Yaron Arbel, Amir Halkin, Yigal Abramowitz, Eran Leshem-Rubinow, Shmuel Banai, Gad Keren, Ariel Finkelstein Tags: Valvular Heart Disease Source Type: research

A Meta-Analysis of Mortality and Major Adverse Cardiovascular and Cerebrovascular Events Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis
The purpose of this meta-analysis was to compare postprocedural mortality and major adverse cardiovascular and cerebrovascular events between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) for severe aortic stenosis. Seventeen studies (n = 4,659) comparing TAVI (n = 2,267) and SAVR (n = 2,392) were included. End points were baseline logistic European System for Cardiac Operative Risk Evaluation score, all-cause mortality, cardiovascular mortality, myocardial infarction, stroke, transient ischemic attack, and major bleeding events. Mean differences or risk ratios with 95% conf...
Source: The American Journal of Cardiology - June 6, 2013 Category: Cardiology Authors: Hemang B. Panchal, Vatsal Ladia, Saurabh Desai, Tejaskumar Shah, Vijay Ramu Tags: Valvular Heart Disease Source Type: research

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