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Stroke revealing Neuro-Beh çet's disease with parenchymal and extensive vascular involvement
The frequency of neurologic manifestations in Beh çet's disease (BD) ranges between 5% and 15% [1]. Central nervous system manifestations are represented by parenchymal involvement, which includes brainstem involvement, hemispheric manifestations, spinal cord lesions, and meningo-encephalitic presentations and non parenchymal involvement, includin g dural sinus thrombosis, arterial occlusion, and/or aneurysms. The association of parenchymal and vascular manifestations is extremely rare [2]. Among the neuro-vasculo-Behçet's disease patients, venous thrombosis is well-known while arterial involvement has rarely been report...
Source: Journal of the Neurological Sciences - January 26, 2019 Category: Neurology Authors: Nouha Hamza, Samia Ben Sassi, Fatma Nabli, Sonia Nagi, Maha Mahmoud, Ines Ben Abdelaziz, Fay çal Hentati Tags: Letter to the Editor Source Type: research

Saving the brain initiative – Developing an effective hub-and-spoke model to improve the acute stroke management pathways in urban India
We aimed to develop and evaluate a hub-and-spoke model in the East Delhi by assessing knowledge and creating awareness through sensitization programs in target communities and among general physicians (GPs) along with implementation of a standard stroke management protocol (SMP) at our institute in order to extend the benefit of thrombolytic therapy.
Source: Journal of the Neurological Sciences - August 9, 2018 Category: Neurology Authors: Suman Kushwaha, Puneet Talwar, Niketa Chandel, Aldrin Anthony, Siddharth Maheshwari, Sarbjeet Khurana Source Type: research

Hyperglycemia predicts unfavorable outcomes in acute ischemic stroke patients treated with intravenous thrombolysis among a Chinese population: A prospective cohort study
In this study, we investigated whether an elevated admission serum glucose level in the 3-h time window of intravenous thrombolysis for acute ischemic stroke determined poor functional outcomes among Chinese population.
Source: Journal of the Neurological Sciences - March 16, 2018 Category: Neurology Authors: Sheng-Feng Lin, A-Ching Chao, Han-Hwa Hu, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Ming-Hui Sun, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Chi-Huey Bai, Taiwan Thrombolytic Therapy for Acut Source Type: research

MRI based thrombolysis for FLAIR-negative stroke patients within 4.5 –6h after symptom onset
To investigate the feasibility of DWI-FLAIR mismatch in identifying patients who might benefit from thrombolytic therapy within 4.5 –6h, we analyzed the data of 105 ischemic stroke patients with known time of symptom onset who underwent MRI within 6h of stroke and thrombolysis between December 2006 and December 2013. They were divided into three groups: symptom onset within 4.5h (n=66); 4.5–6h and FLAIR images negative (n=9) ; and 4.5–6h and FLAIR images positive (n=30). Outcome of thrombolysis was assessed for each group by recanalization rate, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores.
Source: Journal of the Neurological Sciences - November 8, 2016 Category: Neurology Authors: Xiao-Er Wei, Jia Zhou, Wen-Bin Li, Yu-Wu Zhao, Ming-Hua Li, Yue-Hua Li Source Type: research

Outcomes after acute ischemic stroke in patients with thrombocytopenia or thrombocytosis
Thrombocytopenia may be associated with a greater risk of cerebral hemorrhage and thrombocytosis may be associated with a greater risk of cerebral thrombosis. There is a paucity of studies focused on the potential association between blood platelet count (BPC) and outcomes after acute ischemic stroke (AIS). We hypothesized that abnormal BPC is associated with poorer outcomes after AIS.
Source: Journal of the Neurological Sciences - January 23, 2016 Category: Neurology Authors: Julio C. Furlan, Jiming Fang, Frank L. Silver Source Type: research

A novel embolic middle cerebral artery occlusion model induced by thrombus formed in common carotid artery in rat
Stroke is a major cause of death and disability in the worldwide. However, treatment options to date are very limited. To meet the need for validating the novel therapeutic approaches and understanding the physiopathology of the ischemic brain injury, experimental stroke models were critical for preclinical research. However, commonly used embolic stroke models are reluctant to mimic the clinical situation and not suitable for thrombolytic timing studies. In this paper, we established a standard method for producing a rat embolic stroke model with autologous thrombus formed within common carotid artery (CCA) by constant galvanic stimulation.
Source: Journal of the Neurological Sciences - October 2, 2015 Category: Neurology Authors: Yin-Zhong Ma, Li Li, Jun-Ke Song, Zi-Ran Niu, Hai-Feng Liu, Xiang-Shan Zhou, Fu-Sheng Xie, Guan-Hua Du Source Type: research

Chronic kidney disease and intravenous thrombolysis in acute stroke: A systematic review and meta-analysis
The association between chronic kidney disease (CKD) and hemorrhagic complications or clinical outcomes in patients treated with intravenous (IV) thrombolytic agents is controversial.
Source: Journal of the Neurological Sciences - September 17, 2015 Category: Neurology Authors: Jin-Man Jung, Hyun Jung Kim, Hyeongsik Ahn, Il Min Ahn, Youngrok Do, Jeong-Yoon Choi, Woo-Keun Seo, Kyungmi Oh, Kyung-Hee Cho, Sungwook Yu Source Type: research

Post-thrombolysis haemostasis changes after rt-PA treatment in acute cerebral infarct. Correlations with cardioembolic etiology and outcome
: Little is known, in man, in the post-thrombolytic molecular dynamics of haemostasis, particularly the effect of rt-PA on antifibrinolytic components such as alpha2 anti-plasmin and Factor XIII. Aims and hypothesis: The purpose of this study was to systematically determine changes in coagulation and fibrinolytic parameters after thrombolysis with rt-PA during 24hours. We also aimed to correlate these parameters with different acute ischemic stroke subtypes and global outcome. Methods: Eighty consecutive patients with cerebral infarcts treated with rt-PA had their plasma levels of fibrinogen, plasminogen, alpha2-antiplasmi...
Source: Journal of the Neurological Sciences - December 29, 2014 Category: Neurology Authors: Xuhong Sun, Julien Berthiller, Laurent Derex, Paul Trouillas, Laho Diallo, Michel Hanss Source Type: research

Pathological features of intracardiac bacterial vegetation and intracranial arterial thrombus due to infective endocarditis in a stroke patient
We report herein on autopsy and pathological findings for IE-related stroke in a patient receiving hemodialysis.
Source: Journal of the Neurological Sciences - October 17, 2014 Category: Neurology Authors: Takashi Shimoyama, Naoki Saji, Junichi Uemura, Kensaku Shibazaki, Hirotake Nishimura, Kazumi Kimura Tags: Letter to the Editor Source Type: research

Acute recanalization and hyperperfusion in MCA territory due to sole t-PA bolus. A case report
Tissue plasminogen activator (t-PA) is the only approved thrombolytic therapy for the treatment of stroke patients. However, there is discussion whether the current dosing of t-PA (0.9mg/kg) is the optimal choice for all patients [1]. It is also unknown whether the duration of administration (1h) is being optimal. Moreover, there is no information available about the effectiveness of a sole t-PA bolus. The following case demonstrates effectiveness and importance of the bolus of t-PA.
Source: Journal of the Neurological Sciences - September 24, 2014 Category: Neurology Authors: Carsten M. Klingner, Stefan Brodoehl, Christian Hohenstein, Otto W. Witte, Albrecht Günther Tags: Letter to the editor Source Type: research

Gastrointestinal complications after ischemic stroke
Ischemic stroke is an important cause of morbidity and mortality, and currently the leading cause of adult disability in developed countries. Stroke is associated with various non-neurological medical complications, including infections and thrombosis. Gastrointestinal complications after stroke are also common, with over half of all stroke patients presenting with dysphagia, constipation, fecal incontinence or gastrointestinal bleeding. These complications are associated with increased hospital length of stay, the development of further complications and even increased mortality.
Source: Journal of the Neurological Sciences - September 4, 2014 Category: Neurology Authors: Carlos R. Camara-Lemarroy, Beatriz E. Ibarra-Yruegas, Fernando Gongora-Rivera Tags: Review article Source Type: research

Repeated intravenous thrombolysis after recurrent stroke. A case series and review of the literature
Conclusions: IV re-thrombolysis may be safe and effective when recurrent stroke occurs after a period of complete neurologic regression lasting at least 24h or minor disability (mRS score ≤2) lasting at least 3months since the previous stroke.Highlights:
Source: Journal of the Neurological Sciences - July 25, 2014 Category: Neurology Authors: Manuel Cappellari, Giuseppe Moretto, Paolo Bovi Tags: Original Articles Source Type: research

Spontaneous sternocleidomastoid muscle hematoma following thrombolysis for acute ischemic stroke
We report the case of an 83y.o. woman with right facio-brachio-crural hemiparesis, left deviation of the head and aphasia who developed, after thrombolytic therapy, a spontaneous sternocleidomastoid muscle hematoma that regressed few days later. To our knowledge, this is the first case reported in the literature of asymptomatic and spontaneous skeletal muscle hematoma following thrombolysis for the treatment of acute ischemic stroke. The occurrence of lateral cervical tuberculosis lymphadenitis ipsilateral to sternocleidomastoid muscle hematoma may suggest a causal relationship between local chronic inflammation of active ...
Source: Journal of the Neurological Sciences - April 28, 2014 Category: Neurology Authors: Nadia Mariagrazia Giannantoni, Giacomo Della Marca, Aldobrando Broccolini, Fabio Pilato, Paolo Profice, Roberta Morosetti, Pietro Caliandro, Giovanni Frisullo Tags: Letters to the Editor Source Type: research

CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA
Conclusion: CTP parameters derived from commercially available software and published thresholds yield little predictive value for good clinical outcomes for AIS patients treated with IV t-PA but may be useful in predicting poor clinical outcome especially if the area of non-viable tissue is greater than 30cm2.Highlights:
Source: Journal of the Neurological Sciences - April 1, 2014 Category: Neurology Authors: Tzu-Ching Wu, Clark Sitton, Andrew Potter, Ritvij Bowry, Preeti Sahota, Chunyan Cai, Peng Hui, Zhongxue Chen, Nicole Gonzales, Andrew Barreto, George Lopez, James C. Grotta, Sean I. Savitz Tags: Original Articles Source Type: research

The ratio of d-dimer to brain natriuretic peptide may help to differentiate between cerebral infarction with and without acute aortic dissection
Conclusion: We found that the d-dimer:BNP ratio may be helpful in distinguishing between cerebral infarction with and without AAD.Highlights:
Source: Journal of the Neurological Sciences - March 20, 2014 Category: Neurology Authors: Toshiyuki Okazaki, Yoko Yamamoto, Keishi Yoda, Shinji Nagahiro Tags: Original Articles Source Type: research

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