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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Thrombosis
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Total 415 results found since Jan 2013.
The Utility of Middle Cerebral Artery Clot Density and Burden Assessment by Noncontrast Computed Tomography in Acute Ischemic Stroke Patients Treated with Thrombolysis
Conclusions: Utility of the HMCAS as a prognostic marker in stroke thrombolysis is not high in the CT angiography era. Previous observation regarding its positive prognostic role can be attributed to its association with proximal location and extent of clot burden, which are detectable reliably with current CT angiography techniques. Neither quantification nor extent of increased density seems to have clinical utility for treatment decision making in MCA strokes and prediction of emboli composition and response to recanalization attempt.
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2013 Category: Neurology Authors: Mehmet A. Topcuoglu, E. Murat Arsava, Oguzhan Kursun, Erhan Akpinar, Bulent Erbil Tags: Original Articles Source Type: research
Predictors of Cholesterol and Lipoprotein(a) Testing in Children with Arterial Ischemic Stroke
The objective of this study is to identify predictors and modifiable barriers to lipid testing in pediatric stroke.Methods: In this cross-sectional analysis, children (28 days-18 years) with arterial ischemic stroke were identified from the International Pediatric Stroke Study registry (January 2003-April 2012). Analyzed predictors of recorded lipid or lipoprotein a (Lp(a)) testing were age, sex, race, ethnicity, body mass index (BMI) category, other stroke risk factors, country, US region, and recurrent thrombosis.Results: Among 1652 participants (median, 6 years [interquartile range, 1.7-12.7]; 59.0% male; 40.8% white;...
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Sally Sultan, Nicole Schupf, Michael Dowling, Gabrielle DeVeber, Adam Kirton, Mitchell S.V. Elkind, IPSS Investigators Tags: Original Articles Source Type: research
Risk factors and pathogenic microorganism characteristics for pneumonia in convalescent patients with stroke: A retrospective study of 380 patients from a rehabilitation hospital
Stroke significantly impacts public health and ranks among the leading causes of death and disabilities, resulting in enormous costs measured in both health care resources and lost productivity. It results primarily from embolus or thrombosis for ischemic stroke and hypertension for hemorrhagic stroke, respectively [1]. In 2016, there were 5.5 million deaths and 116.4 million disability-adjusted life-years (DALYs) owed to stroke [2]. As reported, the impact of stroke on the Chinese population is more severe compared to average global levels, and the prevalence of stroke continues to surpass that of ischemic heart disease [3 –4].
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Jia Xu, Zhiling Yang Source Type: research
Knowledge of Acute Stroke Management Among Healthcare Professionals: Development and Validation of Acute Stroke Management Questionnaire (ASMaQ)
Around 15.0% of all strokes occurred in hospitalised patients and studies showed significant delay in the stroke recognition and lack of awareness on thrombolytic therapy for acute ischaemic stroke (AIS) which lead to higher mortality for in-hospital stroke. We aimed to develop and validate a new instrument known as acute stroke management questionnaire (ASMaQ) to evaluate the awareness of healthcare professionals in managing acute ischaemic stroke cases.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Chun yang Sim, Wan Asyraf Wan Zaidi, Shamsul Azhar Shah, Wan Nur Nafisah Wan Yahya, Hui jan Tan Source Type: research
Prediction of Thrombolytic Therapy after Stroke-Bypass Transportation: The Maria Prehospital Stroke Scale Score
There is no prehospital stratification tool specifically for predicting thrombolytic therapy after transportation. We developed a new prehospital scale named the Maria Prehospital Stroke Scale (MPSS) by modifying the Cincinnati Prehospital Stroke Scale. Our objective is to evaluate its utility in a citywide bypass transportation protocol for intravenous (IV) tissue plasminogen activator (tPA). In the MPSS, facial droop, arm drift, and speech disturbance are tested by emergency medical technicians (EMTs). Facial droop is graded as normal (0) or abnormal (1), and the other 2 items are graded in 3 levels as normal (0), not se...
Source: Journal of Stroke and Cerebrovascular Diseases - March 13, 2013 Category: Neurology Authors: Yasuhiro Hasegawa, Naoshi Sasaki, Koji Yamada, Hajime Ono, Junichiro Kumai, Kotaro Tsumura, Kazunari Suzuki, Hiroyuki Nozaki, Hitoshi Nakayama, Ichiro Takumi, Hirofumi Nikaido, Tuyoshi Katabami, Toshihiro Ueda, Shinichi Suzuki, Ryosei Iwai, Hiroshi Takaha Tags: Original Articles Source Type: research
Antithrombotic Management of Stroke Patients Before Colonoscopy
Conclusions: In this retrospective analysis, there was no significant difference in the occurrence of stroke, myocardial infarction, venous thromboembolism, and major bleeding between patients who had medications continued around the time of colonoscopy versus those who had temporary discontinuation. A prospective, randomized controlled study is warranted to further elucidate this issue.
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2012 Category: Neurology Authors: Basel Assaad, Veronica Kemerko Sesi, Renzo Figari, Lonni Schultz, Nithin Thummala, Mohammed Rehman, Arun Chandok, Ann Silverman, Brian Silver Tags: Original Articles Source Type: research
Exclusion Criteria for Intravenous Thrombolysis in Stroke Mimics: An Observational Study
Conclusions: SM patients frequently had exclusion criteria for systemic thrombolysis, the most frequent being presenting beyond the established thrombolytic window.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: Alejandro M. Brunser, Sergio Illanes, Pablo M. Lavados, Paula Muñoz, Daniel Cárcamo, Arnold Hoppe, Verónica V. Olavarria, Iris Delgado, Violeta Díaz Tags: Original Articles Source Type: research
Outcomes of Thrombolytic Treatment for Acute Ischemic Stroke in Dialysis-Dependent Patients in the United States
Conclusions: The 2-fold higher odds of in-hospital mortality associated with administration of IV thrombolytics in dialysis-dependent patients who present with acute ischemic stroke warrant a careful assessment of risk–benefit ratio in this population.
Source: Journal of Stroke and Cerebrovascular Diseases - April 30, 2013 Category: Neurology Authors: Nauman Tariq, Malik M. Adil, Fahad Saeed, Saqib A. Chaudhry, Adnan I. Qureshi Tags: Original Articles Source Type: research
Pulmonary Embolism in a Stroke Patient after Systemic Thrombolysis: Clinical Decisions and Literature Review
We describe a 73-year-old man who arrived at the emergency room within 2 hours of acute onset of left hemiparesis who was treated with rt-PA and suffered a pulmonary embolism 3 days after acute stroke therapy. rt-PA is also a current therapy for pulmonary embolism, but an ischemic stroke in the previous 3 months is an absolute contraindication to thrombolysis because of the high risk of intracranial hemorrhage. We discuss clinical and therapeutic decisions and review the current literature.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2013 Category: Neurology Authors: Fabio Pilato, Rosalinda Calandrelli, Paolo Profice, Giacomo Della Marca, Aldobrando Broccolini, Giuseppe Bello, Maria Grazia Bocci, Marisa Distefano, Cesare Colosimo, Paolo Maria Rossini Tags: Case Reports Source Type: research
The iScore Predicts Clinical Response to Tissue Plasminogen Activator in Korean Stroke Patients
Background: Despite substantial differences in clinical features between Asian and Western stroke patients, there are no published prognostic tools validated in an Asiatic population for thrombolytic therapy. We assessed the ability of the iScore to predict the clinical response after intravenous thrombolysis with tissue plasminogen activator (tPA) in a Korean stroke population.Methods: We applied the iScore to eligible participants in the nationwide multicenter stroke registry in Korea. Main outcome measures were poor functional outcome defined as having a modified Rankin Scale score 3-6 and death at 3 months. Symptomati...
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Tai Hwan Park, Sang-Soon Park, Youngchai Ko, Soo Joo Lee, Kyung Bok Lee, Jun Lee, Kyusik Kang, Jong-Moo Park, Jay Chol Choi, Dong-Eog Kim, Yong-Jin Cho, Keun-Sik Hong, Joon-Tae Kim, Dae-Hyun Kim, Jae-Kwan Cha, Moon-Ku Han, Ji Sung Lee, Juneyoung Lee, Kyun Tags: Original Articles Source Type: research
Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats
Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin (AAT), a serine proteinase inhibitor with potent anti-inflammatory, anti-apoptotic, antimicrobial, and cytoprotective activities, could be beneficial in stroke. The goal of this study is to test whether AAT can improve ischemic stroke outcome in an established rat model. Middle cerebral artery occlusion was induced in male rats via intracranial (i.c.) microinjection of endothelin-1. Five to 10 minutes after...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Huong L. Moldthan, Aaron C. Hirko, Jeffrey S. Thinschmidt, Maria B. Grant, Zhimin Li, Joanna Peris, Yuanqing Lu, Ahmed S. Elshikha, Michael A. King, Jeffrey A. Hughes, Sihong Song Tags: Original Articles Source Type: research
Impact of Prehospital Intervention on Delay Time to Thrombolytic Therapy in a Stroke Center with a Systemized Stroke Code Program
The use of emergency medical services (EMS) and notification to hospitals by paramedics for patients with suspected stroke are crucial determinants in reducing delay time to acute stroke treatment. The aim of this study is to investigate whether EMS use and prehospital notification (PN) can shorten the time to thrombolytic therapy in a stroke center with a systemized stroke code program.
Source: Journal of Stroke and Cerebrovascular Diseases - April 6, 2016 Category: Neurology Authors: Dae-Hyun Kim, Hyun-Wook Nah, Hyun-Seok Park, Jae-Hyung Choi, Myong-Jin Kang, Jae-Taeck Huh, Jae-Kwan Cha Source Type: research
Campaign —Once Again Streptokinase Trials (COAST) in Acute Ischemic Stroke
Every year, 1.5 million people suffer from stroke worldwide, the leading cause of disability and the second most common cause of death.1 Stroke incidence in developing countries is much higher and is further rising,2 whereas access to effective acute stroke treatment is very limited. Only 1% stroke sufferers in developing countries have access to the highly expensive tissue plasminogen activator (tPA), the only proven and recommended thrombolytic agent for acute ischemic stroke treatment.3
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2017 Category: Neurology Authors: Muhammad Shabbir, Arsalan Ahmad Tags: Letter to the Editor Source Type: research
Thrombolytic therapy in ischemic stroke patients with pre-stroke depression in the telestroke vs non-telestroke
This study aims to examine clinical risk factors associated with inclusion or exclusion for rtPA in acute ischemic stroke populations with pre-stroke depression in the telestroke versus a non-telestroke setting.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Robyn Moraney, Nicolas Poupore, Rachel Shugart, Mandy Tate, Ashley Snell, Katherine Brown, Thomas I. Nathaniel Source Type: research
